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In response to streptococcal infections, the host innate immune system deploys a repertoire of antimicrobial and immune modulating molecules. One important molecule that is produced in response to streptococcal infections is lactoferrin. Lactoferrin has antimicrobial properties including the ability to bind iron with high affinity and sequester this important nutrient from an invading pathogen. Additionally, lactoferrin has the capacity to alter the host inflammatory response and contribute to disease outcome. This Review presents the most recent published work that studies the interaction between the host innate immune protein lactoferrin and the invading pathogen, Streptococcus.<\/jats:p>","DOI":"10.1021\/acsinfecdis.0c00050","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T11:17:09Z","timestamp":1587727029000},"page":"1615-1623","source":"Crossref","is-referenced-by-count":37,"title":["Lactoferrin: A Critical Mediator of Both Host Immune\nResponse and Antimicrobial Activity in Response to Streptococcal Infections"],"prefix":"10.1021","volume":"6","author":[{"given":"Jacky","family":"Lu","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamisha","family":"Francis","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United 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United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-830X","authenticated-orcid":true,"given":"Schuyler A.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Vanderbilt University , , , ,","place":["Nashville, Tennessee, United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-6121","authenticated-orcid":true,"given":"David M.","family":"Aronoff","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United States, 37232"]},{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Osteen","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United States, 37232"]},{"name":"Tennessee Valley Healthcare Systems , , , ,","place":["Nashville, Tennessee, United States, 37212"]},{"name":"Vanderbilt University Medical Center , , , ,","place":["Nashville, Tennessee, United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Damo","sequence":"additional","affiliation":[{"name":"Fisk University , , , ,","place":["Nashville, Tennessee, United States, 37208"]},{"name":"Vanderbilt University , , , ,","place":["Nashville, Tennessee, United States, 37232"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Manning","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-7235","authenticated-orcid":true,"given":"Steven 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