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This novel coronavirus disease, caused by the SARS-CoV-2 virus, has resulted in severe and unprecedented social and economic disruptions globally. Since the discovery of COVID-19 in December 2019, numerous antivirals have been tested for efficacy against SARS-CoV-2 in vitro and also clinically to treat this disease. This review article discusses the main antiviral strategies currently employed and summarizes reported in vitro and in vivo efficacies of key antiviral compounds in use.<\/jats:p>","DOI":"10.1021\/acsinfecdis.0c00236","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T17:17:58Z","timestamp":1591118278000},"page":"1624-1634","source":"Crossref","is-referenced-by-count":52,"title":["Current Perspective of Antiviral Strategies against\nCOVID-19"],"prefix":"10.1021","volume":"6","author":[{"given":"Bintou A.","family":"Ahidjo","sequence":"first","affiliation":[{"name":"National University of Singapore , , 14 Medical Drive , ,","place":["Singapore, Singapore, 117599"]},{"name":"National University of Singapore , , 5 Science Drive 2 , ,","place":["Singapore, Singapore, 117545"]},{"name":"National University of Singapore , , 10 Medical Drive , ,","place":["Singapore, Singapore, 117597"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Wing Choy","family":"Loe","sequence":"additional","affiliation":[{"name":"National University of Singapore , , 5 Science Drive 2 , ,","place":["Singapore, Singapore, 117545"]},{"name":"National University of Singapore , , 10 Medical Drive , ,","place":["Singapore, Singapore, 117597"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ling","family":"Ng","sequence":"additional","affiliation":[{"name":"National University of Singapore , , 5 Science Drive 2 , ,","place":["Singapore, Singapore, 117545"]},{"name":"National University of Singapore , , 10 Medical Drive , ,","place":["Singapore, Singapore, 117597"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Keng","family":"Mok","sequence":"additional","affiliation":[{"name":"National University of Singapore , , 14 Medical Drive , ,","place":["Singapore, Singapore, 117599"]},{"name":"National University of Singapore , , 5 Science Drive 2 , ,","place":["Singapore, Singapore, 117545"]},{"name":"National University of Singapore , , 10 Medical Drive , ,","place":["Singapore, Singapore, 117597"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-6819","authenticated-orcid":true,"given":"Justin Jang Hann","family":"Chu","sequence":"additional","affiliation":[{"name":"National University of Singapore , , 14 Medical Drive , ,","place":["Singapore, Singapore, 117599"]},{"name":"National University of Singapore , , 5 Science Drive 2 , ,","place":["Singapore, Singapore, 117545"]},{"name":"National University of Singapore , , 10 Medical Drive , ,","place":["Singapore, Singapore, 117597"]},{"name":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR) , , ,","place":["Singapore, Singapore, 138673"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"2026081722183483700_cit1","article-title":"Coronaviruses","volume-title":"Medical Microbiology","author":"Tyrrell","year":"1996"},{"key":"2026081722183483700_cit2","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s12098-020-03263-6","article-title":"A Review of\nCoronavirus Disease-2019 (COVID-19)","volume":"87","author":"Singhal","year":"2020","journal-title":"Indian\nJ. 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