{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:53:47Z","timestamp":1789674827107,"version":"4.0.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI136904"],"award-info":[{"award-number":["RO1AI136904"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Health organizations worldwide have warned that we are on the cusp of a \u201cpost-antibiotic era,\u201d necessitating new approaches to combat antibiotic resistant infections. One such approach is the development of antibiotic adjuvants, which have little or no inherent antibiotic activity at their active concentrations but instead potentiate the activity of antibiotics against antibiotic-resistant bacteria. Recently, we demonstrated that meridianin D, a natural product originally reported to have activity against Staphylococcus aureus and Mycobacterium tuberculosis, possesses the ability to reverse colistin resistance in colistin resistant bacteria. As most natural product screens typically involve screening for only certain activities (anticancer, antiviral, and antimicrobial are typical), we posited that the meridianin D discovery was not unique and there are potentially many natural products that have adjuvant activity. To explore this, the National Cancer Institute (NCI) Natural Product Library Set IV was screened for adjuvant activity using four classes of antibiotics (\u03b2-lactams, aminoglycosides, macrolides, and polymyxins) against three bacterial pathogens (methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, and Klebsiella pneumoniae). Sixteen compounds suppressed \u03b2-lactam resistance in MRSA, five of which effected a 16-fold reduction in the oxacillin minimum inhibitory concentration (MIC). Two natural products effectively suppressed aminoglycoside resistance in both of the Gram-negative species tested, and no hits were observed with macrolides. In contrast, a larger number of natural product adjuvants were identified when screening against colistin-resistant strains of A.\u00a0baumannii and K.\u00a0pneumoniae. Nine compounds reduced the colistin MIC to its breakpoint or lower (up to a 1024-fold reduction). Clorobiocin, novobiocin, and prodigiosin were most effective, reducing the colistin MIC in K.\u00a0pneumoniae strain B9 to 2 \u03bcg\/mL at concentrations as low as 0.625, 2.5, and 1.25 \u03bcM, respectively. Restored sensitivity to colistin with these compounds does not appear to coincide with known mechanisms of colistin resistance.<\/jats:p>","DOI":"10.1021\/acsinfecdis.0c00259","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T18:19:27Z","timestamp":1597774767000},"page":"2629-2640","source":"Crossref","is-referenced-by-count":37,"title":["Screening an Established Natural Product Library Identifies\nSecondary Metabolites That Potentiate Conventional Antibiotics"],"prefix":"10.1021","volume":"6","author":[{"given":"Anne E.","family":"Mattingly","sequence":"first","affiliation":[{"name":"University of Notre Dame , , , ,","place":["Notre Dame, Indiana, United States, 46556"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlie\nE.","family":"Cox","sequence":"additional","affiliation":[{"name":"University of Notre Dame , , , ,","place":["Notre Dame, Indiana, United States, 46556"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Maryland-Baltimore , , , ,","place":["Baltimore, Maryland, United States, 21201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta\nJ.","family":"Melander","sequence":"additional","affiliation":[{"name":"University of Notre Dame , , , ,","place":["Notre Dame, Indiana, United States, 46556"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\nK.","family":"Ernst","sequence":"additional","affiliation":[{"name":"University of Maryland-Baltimore , , , ,","place":["Baltimore, Maryland, United States, 21201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-4696","authenticated-orcid":true,"given":"Christian","family":"Melander","sequence":"additional","affiliation":[{"name":"University of Notre Dame , , , ,","place":["Notre Dame, Indiana, United States, 46556"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2026081722114344800_cit1","volume-title":"Antibiotic Resistance Threats in the\nUnited States, 2019","author":"CDC","year":"2019"},{"key":"2026081722114344800_cit2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3389\/fmicb.2019.00539","article-title":"Emerging\nStrategies to Combat ESKAPE Pathogens in the Era of Antimicrobial\nResistance: A Review","volume":"10","author":"Mulani","year":"2019","journal-title":"Front. Microbiol."},{"key":"2026081722114344800_cit3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1586\/eri.13.12","article-title":"Clinical\nrelevance of the ESKAPE\npathogens","volume":"11","author":"Pendleton","year":"2013","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"2026081722114344800_cit4","first-page":"277","article-title":"The antibiotic\nresistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"P T"},{"key":"2026081722114344800_cit5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic\nAdjuvants: Diverse Strategies\nfor Controlling Drug-Resistant Pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem.\nBiol. Drug Des."},{"key":"2026081722114344800_cit6","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1021\/acsinfecdis.7b00071","article-title":"The Challenge of Overcoming Antibiotic Resistance:\nAn Adjuvant Approach?","volume":"3","author":"Melander","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"2026081722114344800_cit7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2174\/1567201811666140924125740","article-title":"Membrane-permeabilizing\nactivity of reverse-amide 2-aminoimidazole antibiofilm agents against\nAcinetobacter baumannii","volume":"12","author":"Stowe","year":"2015","journal-title":"Curr. Drug Delivery"},{"key":"2026081722114344800_cit8","doi-asserted-by":"publisher","first-page":"17028","DOI":"10.1038\/nmicrobiol.2017.28","article-title":"Pentamidine\nsensitizes Gram-negative\npathogens to antibiotics and overcomes acquired colistin resistance","volume":"2","author":"Stokes","year":"2017","journal-title":"Nat. Microbiol"},{"key":"2026081722114344800_cit9","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1128\/AAC.11.5.852","article-title":"Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces\nclavuligerus","volume":"11","author":"Reading","year":"1977","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026081722114344800_cit10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13445","article-title":"Aspergillomarasmine\nA overcomes metallo-beta-lactamase antibiotic resistance","volume":"510","author":"King","year":"2014","journal-title":"Nature"},{"key":"2026081722114344800_cit11","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1021\/acsinfecdis.5b00086","article-title":"Phosphorylation\nof BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant\nStaphylococcus aureus and Its Abrogation by Small Molecules","volume":"1","author":"Boudreau","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"2026081722114344800_cit12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1021\/cb400490k","article-title":"Small Molecule Downregulation of\nPmrAB Reverses Lipid\nA Modification and Breaks Colistin Resistance","volume":"9","author":"Harris","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"2026081722114344800_cit13","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1002\/med.21591","article-title":"Efflux pump inhibitors\nof clinically relevant multidrug resistant bacteria","volume":"39","author":"Lamut","year":"2019","journal-title":"Med. Res. Rev."},{"key":"2026081722114344800_cit14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.2165\/00003495-198122050-00001","article-title":"Amoxycillin\/clavulanic acid: a review of its antibacterial\nactivity, pharmacokinetics and therapeutic use","volume":"22","author":"Brogden","year":"1981","journal-title":"Drugs"},{"key":"2026081722114344800_cit15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/106002808501900601","article-title":"Amoxicillin-potassium clavulanate:\na novel beta-lactamase inhibitor","volume":"19","author":"McLeod","year":"1985","journal-title":"Drug Intell\nClin Pharm."},{"key":"2026081722114344800_cit16","doi-asserted-by":"publisher","first-page":"14477","DOI":"10.1073\/pnas.1618221114","article-title":"Antibiotic discovery is a walk in\nthe park","volume":"113","author":"Nothias","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026081722114344800_cit17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s002030100345","article-title":"How many antibiotics\nare produced by the genus Streptomyces?","volume":"176","author":"Watve","year":"2001","journal-title":"Arch.\nMicrobiol."},{"key":"2026081722114344800_cit18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.bjid.2012.08.014","article-title":"Antibiotics produced by Streptomyces","volume":"16","author":"de\nLima Procopio","year":"2012","journal-title":"Braz. J. Infect. Dis."},{"key":"2026081722114344800_cit19","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1021\/np030096l","article-title":"Natural products\nas sources of new\ndrugs over the period 1981\u20132002","volume":"66","author":"Newman","year":"2003","journal-title":"J. Nat.\nProd."},{"key":"2026081722114344800_cit20","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrd1657","article-title":"The evolving role\nof natural products in drug discovery","volume":"4","author":"Koehn","year":"2005","journal-title":"Nat.\nRev. Drug Discovery"},{"key":"2026081722114344800_cit21","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.cbpa.2007.08.012","article-title":"Natural\nproducts as a screening resource","volume":"11","author":"Harvey","year":"2007","journal-title":"Curr. Opin.\nChem. Biol."},{"key":"2026081722114344800_cit22","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1021\/acschembio.8b00389","article-title":"NCI Program for Natural Product Discovery:\nA Publicly-Accessible Library of Natural Product Fractions for High-Throughput\nScreening","volume":"13","author":"Thornburg","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"2026081722114344800_cit23","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1039\/c3md00097d","article-title":"Meridianin\nG and its analogs as antimalarial\nagents","volume":"4","author":"Bharate","year":"2013","journal-title":"MedChemComm"},{"key":"2026081722114344800_cit24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejmech.2015.05.020","article-title":"Synthesis, antimalarial\nand antitubercular activities\nof meridianin derivatives","volume":"98","author":"Yadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"2026081722114344800_cit25","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1021\/acsmedchemlett.8b00161","article-title":"Meridianin D Analogues\nDisplay Antibiofilm Activity\nagainst MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria","volume":"9","author":"Huggins","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"2026081722114344800_cit26","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1093\/infdis\/jit293","article-title":"Emergence\nof Colistin-Resistance in Extremely Drug-Resistant Acinetobacter baumannii\nContaining a Novel pmrCAB Operon During Colistin Therapy of Wound\nInfections","volume":"208","author":"Lesho","year":"2013","journal-title":"J. Infect. Dis."},{"key":"2026081722114344800_cit27","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1093\/jac\/dkx234","article-title":"Structural\nmodification of LPS in\ncolistin-resistant, KPC-producing Klebsiella pneumoniae","volume":"72","author":"Leung","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"2026081722114344800_cit28","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41467-018-02875-z","article-title":"Overcoming\nmcr-1\nmediated colistin resistance with colistin in combination with other\nantibiotics","volume":"9","author":"MacNair","year":"2018","journal-title":"Nat. Commun."},{"key":"2026081722114344800_cit29","doi-asserted-by":"publisher","first-page":"6749","DOI":"10.1021\/jacs.8b02283","article-title":"Novobiocin Enhances Polymyxin Activity\nby Stimulating Lipopolysaccharide\nTransport","volume":"140","author":"Mandler","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"2026081722114344800_cit30","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.bbalip.2017.01.004","article-title":"Lipid A structural\nmodifications in extreme conditions and identification of unique modifying\nenzymes to define the Toll-like receptor 4 structure-activity relationship","volume":"1862","author":"Scott","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"2026081722114344800_cit31","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1046\/j.1365-2958.1998.00757.x","article-title":"PmrA-PmrB-regulated\ngenes necessary\nfor 4-aminoarabinose lipid A modification and polymyxin resistance","volume":"27","author":"Gunn","year":"1998","journal-title":"Mol. Microbiol."},{"key":"2026081722114344800_cit32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41579-019-0201-x","article-title":"Pushing the envelope:\nLPS modifications and their consequences","volume":"17","author":"Simpson","year":"2019","journal-title":"Nat.\nRev. Microbiol."},{"key":"2026081722114344800_cit33","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/ijms20020356","article-title":"Regulated Assembly of LPS, Its Structural\nAlterations and Cellular\nResponse to LPS Defects","volume":"20","author":"Klein","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026081722114344800_cit34","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1128\/AAC.00256-11","article-title":"The pmrCAB operon\nmediates polymyxin resistance in\nAcinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine\nmodification of lipid A","volume":"55","author":"Arroyo","year":"2011","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081722114344800_cit35","doi-asserted-by":"publisher","first-page":"6857","DOI":"10.1128\/JB.178.23.6857-6864.1996","article-title":"PhoP-PhoQ activates transcription of pmrAB, encoding\na two-component regulatory system involved in Salmonella typhimurium\nantimicrobial peptide resistance","volume":"178","author":"Gunn","year":"1996","journal-title":"J. Bacteriol."},{"key":"2026081722114344800_cit36","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1128\/AAC.05829-11","article-title":"PmrB Mutations Promote\nPolymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated\nCystic Fibrosis Patients","volume":"56","author":"Moskowitz","year":"2012","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081722114344800_cit37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1423-0127-17-60","article-title":"Molecular characterization of the\nPhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance\nin Klebsiella pneumoniae CG43","volume":"17","author":"Cheng","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"2026081722114344800_cit38","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.1128\/AAC.01480-13","article-title":"In Vivo\nEmergence of Colistin Resistance in Klebsiella pneumoniae Producing\nKPC-Type Carbapenemases Mediated by Insertional Inactivation of the\nPhoQ\/PhoP mgrB Regulator","volume":"57","author":"Cannatelli","year":"2013","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081722114344800_cit39","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1128\/AAC.05055-14","article-title":"Heteroresistance to\ncolistin in Klebsiella pneumoniae associated with alterations in the\nPhoPQ regulatory system","volume":"59","author":"Jayol","year":"2015","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081722114344800_cit40","doi-asserted-by":"publisher","first-page":"17221","DOI":"10.1021\/jacs.7b07736","article-title":"The Antibiotic Novobiocin Binds and\nActivates the ATPase That Powers Lipopolysaccharide Transport","volume":"139","author":"May","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026081722114344800_cit41","doi-asserted-by":"publisher","first-page":"5749","DOI":"10.1016\/j.bmc.2017.08.055","article-title":"Small molecule adjuvants that suppress both chromosomal\nand mcr-1 encoded colistin-resistance and amplify colistin efficacy\nin polymyxin-susceptible bacteria","volume":"25","author":"Barker","year":"2017","journal-title":"Bioorg. Med.\nChem."},{"key":"2026081722114344800_cit42","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.1128\/AAC.00756-12","article-title":"Rapid killing\nof Acinetobacter baumannii by polymyxins is mediated by a hydroxyl\nradical death pathway","volume":"56","author":"Sampson","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026081722114344800_cit43","doi-asserted-by":"publisher","first-page":"e0162412","DOI":"10.1371\/journal.pone.0162412","article-title":"Prodigiosin - A Multifaceted\nEscherichia coli Antimicrobial Agent","volume":"11","author":"Danevcic","year":"2016","journal-title":"PLoS One"},{"key":"2026081722114344800_cit44","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13568-016-0222-z","article-title":"Prodigiosin\ninhibits motility and activates bacterial\ncell death revealing molecular biomarkers of programmed cell death","volume":"6","author":"Darshan","year":"2016","journal-title":"AMB Express"},{"key":"2026081722114344800_cit45","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/S0006-2952(03)00496-9","article-title":"The prodigiosins,\nproapoptotic drugs with anticancer properties","volume":"66","author":"Perez-Tomas","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"2026081722114344800_cit46","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.1007\/s00253-014-5590-1","article-title":"Properties and applications of undecylprodigiosin\nand\nother bacterial prodigiosins","volume":"98","author":"Stankovic","year":"2014","journal-title":"Appl. Microbiol.\nBiotechnol."},{"key":"2026081722114344800_cit47","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2217\/17460913.2.6.605","article-title":"Anticancer and immunosuppressive properties of bacterial\nprodiginines","volume":"2","author":"Williamson","year":"2007","journal-title":"Future Microbiol."},{"key":"2026081722114344800_cit48","doi-asserted-by":"publisher","first-page":"107614","DOI":"10.1016\/j.jmgm.2020.107614","article-title":"Molecular dynamics of the membrane\ninteraction and localisation of prodigiosin","volume":"98","author":"Ravindran","year":"2020","journal-title":"J. Mol. Graphics Modell."},{"key":"2026081722114344800_cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200940","article-title":"Natural biocide cocktails: Combinatorial\nantibiotic effects of prodigiosin and biosurfactants","volume":"13","author":"Hage-Hulsmann","year":"2018","journal-title":"PLoS One"},{"key":"2026081722114344800_cit50","first-page":"3325","article-title":"Differential genomic\ndamage in different tumor lines induced by prodigiosin","volume":"35","author":"Lins","year":"2015","journal-title":"Anticancer research"},{"key":"2026081722114344800_cit51","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1021\/acsinfecdis.8b00103","article-title":"New Class of Adjuvants\nEnables Lower Dosing of Colistin Against Acinetobacter baumannii","volume":"4","author":"Minrovic","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"2026081722114344800_cit52","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1021\/acsinfecdis.8b00288","article-title":"Using Small-Molecule\nAdjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa","volume":"5","author":"Hubble","year":"2019","journal-title":"ACS Infect. Dis."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.0c00259","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/10\/2629\/6313078\/id0c00259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/10\/2629\/6313078\/id0c00259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:36:05Z","timestamp":1787042165000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/6\/10\/2629\/614085\/Screening-an-Established-Natural-Product-Library"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,8,18]]},"published-print":{"date-parts":[[2020,10,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.0c00259","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]}}}