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The virus has spread very rapidly to many countries across the world, resulting in the World Health Organization (WHO) to declare a pandemic on March 11, 2020. Clinically, the diagnosis of this unprecedented illness, called coronavirus disease-2019 (COVID-19), becomes difficult because it shares many symptoms with other respiratory pathogens, including influenza and parainfluenza viruses. Therefore, laboratory diagnosis is crucial for the clinical management of patients and the implementation of disease control strategies to contain SARS-CoV-2 at clinical and population level. Here, we summarize the main clinical and imaging findings of COVID-19 patients and discuss the advances, features, advantages, and limitations of different laboratory methods used for SARS-CoV-2 diagnosis.<\/jats:p>","DOI":"10.1021\/acsinfecdis.0c00274","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:48:30Z","timestamp":1596556110000},"page":"2319-2336","source":"Crossref","is-referenced-by-count":72,"title":["Clinical and Laboratory Diagnosis of SARS-CoV-2, the\nVirus Causing COVID-19"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-4727","authenticated-orcid":true,"given":"Severino Jefferson Ribeiro","family":"da Silva","sequence":"first","affiliation":[{"name":"Aggeu Magalha\u0303es Institute (IAM) , , Oswaldo Cruz Foundation (Fiocruz) , , , ,","place":["Recife, Pernambuco, Brazil, 50670-420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Targino Alves da","family":"Silva","sequence":"additional","affiliation":[{"name":"Aggeu Magalha\u0303es Institute (IAM) , , Oswaldo Cruz Foundation (Fiocruz) , , , ,","place":["Recife, Pernambuco, Brazil, 50670-420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klarissa Miranda","family":"Guarines","sequence":"additional","affiliation":[{"name":"Aggeu Magalha\u0303es Institute (IAM) , , Oswaldo Cruz Foundation (Fiocruz) , , , ,","place":["Recife, Pernambuco, Brazil, 50670-420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Pesso\u0302a Germano","family":"Mendes","sequence":"additional","affiliation":[{"name":"Aggeu Magalha\u0303es Institute (IAM) , , Oswaldo Cruz Foundation (Fiocruz) , , , ,","place":["Recife, Pernambuco, Brazil, 50670-420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Pardee","sequence":"additional","affiliation":[{"name":"University of Toronto , , , ,","place":["Toronto, ON, Canada, M5S 3M2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Kohl","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research , , G61 1QH ,","place":["Glasgow, Scotland, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-5699","authenticated-orcid":true,"given":"Lindomar","family":"Pena","sequence":"additional","affiliation":[{"name":"Aggeu Magalha\u0303es Institute (IAM) , , Oswaldo Cruz Foundation (Fiocruz) , , , ,","place":["Recife, Pernambuco, Brazil, 50670-420"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"2026090304041068200_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-2438-7_1","article-title":"Coronaviruses:\nan overview of their replication and\npathogenesis","volume":"1282","author":"Fehr","year":"2015","journal-title":"Methods Mol. 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