{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:25:36Z","timestamp":1787045136646,"version":"build-2736575974"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI103280"],"award-info":[{"award-number":["R01AI103280"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21-AI123808"],"award-info":[{"award-number":["R21-AI123808"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21-AI130584"],"award-info":[{"award-number":["R21-AI130584"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infection with malarial parasites renders hosts more mosquito-attractive than their uninfected, healthy counterparts. One volatile organic compound, \u03b1-pinene, is associated with Plasmodium spp. infection in multiple studies and is a known mosquito attractant. However, how malarial infection results in elevated levels of host-associated \u03b1-pinene remains unclear. One study suggested that exposure of erythrocytes to the malarial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) results in increased levels of \u03b1-pinene. Here we establish that endogenous levels of \u03b1-pinene are present in human erythrocytes, that these levels vary widely by erythrocyte donor, and that \u03b1-pinene levels are not altered by HMBPP treatment.<\/jats:p>","DOI":"10.1021\/acsinfecdis.0c00548","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:39:11Z","timestamp":1600871951000},"page":"2567-2572","source":"Crossref","is-referenced-by-count":6,"title":["The Malaria Metabolite HMBPP Does Not Trigger Erythrocyte\nTerpene Release"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-8916","authenticated-orcid":true,"given":"Justin J.","family":"Miller","sequence":"first","affiliation":[{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-8537","authenticated-orcid":true,"given":"Audrey R.","family":"Odom John","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]},{"name":"Washington University School of Medicine , , , ,","place":["St. Louis, Missouri, United States, 63110"]},{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"2026081722111767400_cit1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0020-7519(03)00112-7","article-title":"The dynamics of\ninteractions between Plasmodium and the mosquito:\na study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes\naegypt","volume":"33","author":"Alavi","year":"2003","journal-title":"Int. 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Lett."},{"key":"2026081722111767400_cit8","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/infdis\/jiy072","article-title":"Breathprinting\nreveals malaria-associated biomarkers and mosquito attractants","volume":"217","author":"Schaber","year":"2018","journal-title":"J. Infect. Dis."},{"key":"2026081722111767400_cit9","doi-asserted-by":"publisher","first-page":"046014","DOI":"10.1088\/1752-7163\/aadbbb","article-title":"Diurnal variation in expired breath\nvolatiles in malaria-infected and healthy volunteers","volume":"12","author":"Berna","year":"2018","journal-title":"J. Breath Res."},{"key":"2026081722111767400_cit10","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1073\/pnas.1801512115","article-title":"Volatile\nbiomarkers of symptomatic and asymptomatic malaria infection in humans","volume":"115","author":"De Moraes","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. 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Rep."},{"key":"2026081722111767400_cit14","doi-asserted-by":"publisher","first-page":"e00235-15","DOI":"10.1128\/mBio.00235-15","article-title":"Malaria parasites\nproduce volatile mosquito attractants","volume":"6","author":"Kelly","year":"2015","journal-title":"mBio"},{"key":"2026081722111767400_cit15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3109\/10408417609102303","article-title":"Volatile\norganic compounds and microorganisms","volume":"4","author":"Stotzky","year":"1976","journal-title":"CRC Crit.\nRev. Microbiol."},{"key":"2026081722111767400_cit16","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1021\/ar200198d","article-title":"Exploration and mining of the bacterial\nterpenome","volume":"45","author":"Cane","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"2026081722111767400_cit17","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1073\/pnas.1422108112","article-title":"Terpene synthases\nare widely distributed in bacteria","volume":"112","author":"Yamada","year":"2015","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"key":"2026081722111767400_cit18","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.1038\/ncomms7279","article-title":"Volatile signalling by sesquiterpenes from ectomycorrhizal fungi\nreprogrammes root architecture","volume":"6","author":"Ditengou","year":"2015","journal-title":"Nat. Commun."},{"key":"2026081722111767400_cit19","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1039\/c2md20030a","article-title":"Isotuberculosinol:\nthe unusual case of an immunomodulatory diterpenoid from Mycobacterium\ntuberculosis","volume":"3","author":"Mann","year":"2012","journal-title":"MedChemComm"},{"key":"2026081722111767400_cit20","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1073\/pnas.1523468113","article-title":"Novel family\nof terpene synthases evolved from trans-isoprenyl diphosphate synthases\nin a flea beetle","volume":"113","author":"Beran","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.\nS. 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Rep."},{"key":"2026081722111767400_cit25","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1126\/science.aah4563","article-title":"A key malaria metabolite\nmodulates vector blood seeking, feeding, and susceptibility to infection","volume":"355","author":"Emami","year":"2017","journal-title":"Science"},{"key":"2026081722111767400_cit26","doi-asserted-by":"publisher","first-page":"13172","DOI":"10.1073\/pnas.240454797","article-title":"Isoprenoid biosynthesis:\nthe evolution of two ancient and distinct pathways across genomes","volume":"97","author":"Lange","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026081722111767400_cit27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the\nmevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"2026081722111767400_cit28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S0014-5793(03)00483-6","article-title":"Microbial isoprenoid\nbiosynthesis and human \u03b3\u03b4 T cell activation","volume":"544","author":"Eberl","year":"2003","journal-title":"FEBS Lett."},{"key":"2026081722111767400_cit29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin\n2A1 is essential for phosphoantigen reactivity by \u03b3\u03b4 T\ncells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"2026081722111767400_cit30","volume-title":"Physical and Thermodynamic Properties of Pure\nChemicals: Data Compilation","author":"Daubert","year":"1989"},{"key":"2026081722111767400_cit31","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1172\/JCI115442","article-title":"Red blood\ncells are a sink for interleukin 8, a leukocyte chemotaxin","volume":"88","author":"Darbonne","year":"1991","journal-title":"J. Clin. Invest."},{"key":"2026081722111767400_cit32","doi-asserted-by":"crossref","first-page":"12247","DOI":"10.1016\/S0021-9258(18)31379-6","article-title":"Identification\nof a promiscuous inflammatory peptide receptor on the surface of red\nblood cells","volume":"268","author":"Neote","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2026081722111767400_cit33","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1242\/jeb.116798","article-title":"Functional\ndevelopment of carbon dioxide detection in the maxillary palp of Anopheles gambiae","volume":"218","author":"Omondi","year":"2015","journal-title":"J. Exp. Biol."},{"key":"2026081722111767400_cit34","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1242\/jeb.01736","article-title":"Carbon\ndioxide instantly sensitizes female yellow fever mosquitoes to human\nskin odours","volume":"208","author":"Dekker","year":"2005","journal-title":"J. Exp. Biol."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.0c00548","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/10\/2567\/6313091\/id0c00548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/10\/2567\/6313091\/id0c00548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:34:56Z","timestamp":1787042096000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/6\/10\/2567\/614086\/The-Malaria-Metabolite-HMBPP-Does-Not-Trigger"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,9,23]]},"published-print":{"date-parts":[[2020,10,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.0c00548","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.29.225839","asserted-by":"object"}]},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,23]]}}}