{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:47:38Z","timestamp":1788580058694,"version":"build-2803163510"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell?Istruzione, dell?Universit? e della Ricerca","doi-asserted-by":"publisher","award":["FISR2019_04819 BacCAD"],"award-info":[{"award-number":["FISR2019_04819 BacCAD"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI148523"],"award-info":[{"award-number":["1R01AI148523"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016599","name":"Purdue Institute for Drug Discovery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2021,7,9]]},"DOI":"10.1021\/acsinfecdis.1c00055","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T21:16:34Z","timestamp":1616706994000},"page":"1969-1984","source":"Crossref","is-referenced-by-count":82,"title":["Structure\u2013Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against <i>Neisseria gonorrhoeae<\/i>"],"prefix":"10.1021","volume":"7","author":[{"given":"Chad S.","family":"Hewitt","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader S.","family":"Abutaleb","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E. M.","family":"Elhassanny","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":true,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze 50122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon P.","family":"Amos","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly S.","family":"Youse","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina J.","family":"Holly","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Marapaka","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"An","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-7909","authenticated-orcid":true,"given":"Jatinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Krabill","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elkashif","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehia","family":"Elgammal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Graboski","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":true,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze 50122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0939-0458","authenticated-orcid":true,"given":"Mohamed N.","family":"Seleem","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-0606","authenticated-orcid":true,"given":"Daniel P.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States"},{"name":"Purdue Institute for Drug Discovery, 720 Clinic Drive, West Lafayette, Indiana 47907, United States"},{"name":"Purdue Institute of Inflammation, Immunology and Infectious Disease, 207 South Martin Jischke Drive, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health\nOrganization (2020) Multi-drug resistant gonorrhoea Fact\nSheet, WHO, Geneva. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/multi-drug-resistant-gonorrhoea."},{"key":"ref2\/cit2","volume-title":"Sexually Transmitted Disease Surveillance 2018","author":"Bowen V. B.","year":"2019"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"e01461","DOI":"10.1128\/JCM.01461-19","volume":"58","author":"Kersh E. N.","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090816-093530"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.05.077"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10451.x"},{"key":"ref7\/cit7","first-page":"173","volume-title":"Seminars in arthritis and rheumatism","author":"Masi A. T.","year":"1981"},{"key":"ref8\/cit8","first-page":"209","volume":"45","author":"Kerle K. K.","year":"1992","journal-title":"Am. Fam. Physician"},{"key":"ref9\/cit9","first-page":"213","volume-title":"Emerging Infections","author":"Unemo M.","year":"2016","edition":"10"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002344"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.15585\/mmwr.mm6950a6","volume":"69","author":"Cyr S. S.","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref12\/cit12","volume-title":"Antimicrobial resistance: global report on surveillance","author":"World Health Organization","year":"2014"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1112456"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","DOI":"10.15620\/cdc:82532","volume-title":"Antibiotic resistance threats in the United States","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00230-16"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1071\/SH19034"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000971"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706988"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy145"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.08.037"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jm031057+"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1960.198.2.434"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(54)92027-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1967.47.4.595"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","DOI":"10.4324\/9780203475300","volume-title":"Carbonic anhydrase: its inhibitors and activators","author":"Supuran C. T.","year":"2004"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00006-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100912"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1159\/000047397"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.10.043"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jm0501073"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jm030911u"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00034"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1811853"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00417"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1755852"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25102269"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00194"},{"key":"ref39\/cit39","first-page":"204","volume":"3","author":"Sanders E.","year":"1967","journal-title":"Mol. Pharmacol."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00755.x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2077"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02031.x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku762"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00734"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1867122"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.305"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/ja954102e"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.05.055"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-32-1-1"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"e01225","DOI":"10.1128\/AAC.01225-19","volume":"63","author":"Alhashimi M.","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-62696-3","volume":"10","author":"Elkashif A.","year":"2020","journal-title":"Sci. Rep."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"e02206","DOI":"10.1128\/AAC.02206-19","volume":"64","author":"Seong Y. J.","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/med.21713"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600660532"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309109036665"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/jmbi.1994.1655","volume":"234","author":"Chakraverty S.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy237"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nbt.3080","volume":"33","author":"Klijn C.","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22144"},{"key":"ref61\/cit61","first-page":"6394","volume":"61","author":"Loncaster J. A.","year":"2001","journal-title":"Cancer Res."},{"key":"ref62\/cit62","first-page":"74","volume":"21","author":"Woods D. D.","year":"1940","journal-title":"Br. J. Exp. Pathol."},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00010-14"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198304000-00007"},{"key":"ref65\/cit65","first-page":"81","volume":"25","author":"Dunlop E. M. C.","year":"1949","journal-title":"Br. J. Vener. Dis."},{"key":"ref66\/cit66","first-page":"45","volume-title":"Biochemistry. Structure and Bonding","volume":"48","author":"Bertini I.","year":"1982"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040509"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/nature22308"},{"key":"ref70\/cit70","unstructured":"Maynard, R. L. (2001)  The Merck Index, 13th ed. pp 11, Merck & Co, Inc., Whitehouse Station, NJ."},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.7.2300-2308.2006"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/jm700967e"},{"key":"ref73\/cit73","volume-title":"Therapeutic drugs","volume":"2","author":"Dollery C. T.","year":"1991"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000322"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1985.tb02655.x"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1992.tb03806.x"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.217"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600660416"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/.bmcl.2013.11.030"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.10.070"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1113407"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104183"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111593"},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"e02115","DOI":"10.1128\/AAC.02115-19","volume":"64","author":"Abutaleb N. S.","year":"2020","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.1c00055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:44:11Z","timestamp":1682477051000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.1c00055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,9]]}},"alternative-id":["10.1021\/acsinfecdis.1c00055"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.1c00055","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]}}}