{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:39Z","timestamp":1792794099645,"version":"4.5.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/K005138\/1"],"award-info":[{"award-number":["EP\/K005138\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N006615\/1"],"award-info":[{"award-number":["EP\/N006615\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N03371X\/1"],"award-info":[{"award-number":["EP\/N03371X\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N501852\/1"],"award-info":[{"award-number":["MR\/N501852\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013281","name":"Joint Programming Initiative on Antimicrobial Resistance","doi-asserted-by":"publisher","award":["MR\/N501852\/1"],"award-info":[{"award-number":["MR\/N501852\/1"]}],"id":[{"id":"10.13039\/100013281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["BB\/R012415\/1"],"award-info":[{"award-number":["BB\/R012415\/1"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R012415\/1"],"award-info":[{"award-number":["BB\/R012415\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hartree Centre","award":["BB\/R012415\/1"],"award-info":[{"award-number":["BB\/R012415\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2021,9,10]]},"DOI":"10.1021\/acsinfecdis.1c00175","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T08:05:01Z","timestamp":1629187501000},"page":"2666-2685","source":"Crossref","is-referenced-by-count":48,"title":["Design and Evaluation of New Quinazolin-4(3\n                    <i>H<\/i>\n                    )-one Derived PqsR Antagonists as Quorum Sensing Quenchers in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1021","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-2543","authenticated-orcid":true,"given":"Fadi","family":"Soukarieh","sequence":"first","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Mashabi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Richardson","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard Vico","family":"Oton","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Romero","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun N.","family":"Roberston","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Grossman","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Sou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Uppsala University, Uppsala SE-751 23, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Halliday","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Kukavica-Ibrulj","sequence":"additional","affiliation":[{"name":"Institut de Biologie Integrative et des Systemes, Universite Laval, Quebec G1 V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger C.","family":"Levesque","sequence":"additional","affiliation":[{"name":"Institut de Biologie Integrative et des Systemes, Universite Laval, Quebec G1 V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel A. S.","family":"Bergstrom","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Uppsala University, Uppsala SE-751 23, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-9908","authenticated-orcid":true,"given":"Barrie","family":"Kellam","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Emsley","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Heeb","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-137X","authenticated-orcid":true,"given":"Michael J.","family":"Stocks","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"C\u00e1mara","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."},{"name":"The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30605-4"},{"key":"ref2\/cit2","unstructured":"Pew Trusts. Antibiotics Currently\nin Global Clinical Development. https:\/\/www.pewtrusts.org\/en\/research-and-analysis\/data-visualizations\/2014\/antibiotics-currently-in-clinical-development (accessed March 15, 2021)."},{"key":"ref3\/cit3","unstructured":"World Health Organisation. (2017)\n                      Guidelines for the prevention\nand control of carbapenem-resistant Enterobacteriaceae, Acinetobacter\nbaumannii and Pseudomonas aeruginosa in health care facilities\n                      ."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.10.1353"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/82_2015_490"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0288-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00540"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.08.001"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0100-x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102108-134304"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.01.005"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.01.006"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006029"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001116"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700015"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00575"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.049"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00204"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112778"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jm051256o"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306430"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.009"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.10.060"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.03.049"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.12.051"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/1570179417666200917102634"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/p29960000973"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2017.01.007"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1134\/S107042800705020X"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1055\/s-1989-27441"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.077"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003508"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-013-1552-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8080236"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00252"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01036"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01582"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02158-17"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky019"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b01139"},{"key":"ref41\/ci41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61137-5"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03695"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02055"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00773C"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2019.1621649"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01296-18"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020257"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/science.7604262"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1101\/gr.086082.108"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.11.014"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.1976"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.158"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.2.884-900.1990"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-10-2395"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01606.x"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.1c00175","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.1c00175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T19:43:43Z","timestamp":1682538223000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.1c00175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9,10]]}},"alternative-id":["10.1021\/acsinfecdis.1c00175"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.1c00175","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]}}}