{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:41:38Z","timestamp":1790145698978,"version":"4.0.1"},"reference-count":92,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15AI142699"],"award-info":[{"award-number":["1R15AI142699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2021,8,13]]},"DOI":"10.1021\/acsinfecdis.1c00185","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T19:12:55Z","timestamp":1625080375000},"page":"2425-2436","source":"Crossref","is-referenced-by-count":27,"title":["Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of \u03b2-Lactamase Inhibitors"],"prefix":"10.1021","volume":"7","author":[{"given":"Rashmi","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Immunity and Pathogenesis, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, 6900 Lake Nona Blvd., Orlando, Florida 32827, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora M. S. A.","family":"Al-Kharji","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha A.","family":"Alqurafi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirui","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pojun","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breven S.","family":"Simcox","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, 6900 Lake Nona Blvd., Orlando, Florida 32827, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mass Spectrometry Facility, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-5505","authenticated-orcid":true,"given":"Leighanne A.","family":"Brammer Basta","sequence":"additional","affiliation":[{"name":"Chemistry Department, United States Naval Academy, 572M Holloway Road, Annapolis, Maryland 21402, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3238","authenticated-orcid":true,"given":"Kyle H.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, 6900 Lake Nona Blvd., Orlando, Florida 32827, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-791X","authenticated-orcid":true,"given":"John D.","family":"Buynak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.042"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3201\/2109.141634"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01977"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00125812"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2015.51.2.2245645"},{"key":"ref6\/cit6","first-page":"70","volume":"77","author":"Robinson H. J.","year":"1943","journal-title":"J. Pharmacol."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2307\/4584828"},{"key":"ref8\/cit8","first-page":"595","volume":"27","author":"Bil\u2019ko I. P.","year":"1982","journal-title":"Antibiotiki"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700610303"},{"key":"ref10\/cit10","first-page":"315","volume":"10","author":"Kasik J. E.","year":"1964","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref11\/cit11","first-page":"45","author":"Vinogradova T. I.","year":"1993","journal-title":"Probl Tuberk"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2816-2821.2005"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/19.1.59"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.12.2620"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1182"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1375"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bi701506h"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01035-15"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00023-13"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167498"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt410"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku510"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz433"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00614-19"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02623-18"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02895-18"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0234"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01158-15"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00866-17"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00623-18"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57844-8"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S252485"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-020-02000-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01475-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.7.2341-2347.2005"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuz016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00606-10"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bi00714a008"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507384200"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06887.x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.069211-0"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.259150"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008195"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02185-20"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912048998"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2237"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00665-12"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08199.x"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01663-13"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2012.09.016"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2120"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00098-20"},{"key":"ref53\/cit53","volume-title":"WHO Consolidated Guidelines on Drug-Resistant Tuberculosis Treatment","author":"WHO","year":"2019"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030373"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00214-2016"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02146-2015"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01278-2015"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210927"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(16)00018-7"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01991-2018"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa-2019-0098"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix893"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01076-18"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6010001"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160310144501"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150825115824"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059654"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00296-11"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.1100"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00096"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)79446-9"},{"key":"ref72\/cit72","unstructured":"Ueda, Y., and Roberge, G. (1986) Carbapenem intermediates. GB2173801A."},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw546"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201809424"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/bi400177y"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201405243"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00234"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14010"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01956-20"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00119"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.1.52"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55452-1"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01289.x"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4163-4170.2004"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00239-08"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26902-0"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.19.5479-5490.2002"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000988"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28625-0"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00743-17"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02204"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01696-17"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.1c00185","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.1c00185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T09:51:50Z","timestamp":1688377910000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.1c00185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":92,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,13]]}},"alternative-id":["10.1021\/acsinfecdis.1c00185"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.1c00185","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}