{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:36:03Z","timestamp":1790386563038,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["1S10OD025252-01"],"award-info":[{"award-number":["1S10OD025252-01"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["2R15AI 103889-02"],"award-info":[{"award-number":["2R15AI 103889-02"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006466","name":"Cleveland State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006466","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2022,8,12]]},"DOI":"10.1021\/acsinfecdis.2c00331","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:00:16Z","timestamp":1658919616000},"page":"1711-1726","source":"Crossref","is-referenced-by-count":2,"title":["Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis"],"prefix":"10.1021","volume":"8","author":[{"given":"Cody M.","family":"Orahoske","sequence":"first","affiliation":[{"name":"Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences & Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjia","family":"Afrin","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences & Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences & Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myah","family":"Marbury","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences & Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-441X","authenticated-orcid":true,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences & Health Professions, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio44115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/B978-0-323-55512-8.00102-2","volume-title":"Hunter\u2019s Tropical Medicine and Emerging Infectious Diseases","author":"Krishna S.","year":"2020"},{"key":"ref2\/cit2","unstructured":"WHO. Ending the Neglect to Attain the Sustainable Development Goals (A\nRoad Map for Neglected Tropical Disease 2021-2030) Overview Word Health Organization, 2021."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60829-1"},{"key":"ref4\/cit4","first-page":"90","volume":"5","author":"Smith S.","year":"2007","journal-title":"Int. J. Global Health Health Disparities"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003397"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115538"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00427-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-15"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0924-8579(94)90012-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000923"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s40267-019-00672-2"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008261"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2010171061"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00039"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03686-X"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01664"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.422501"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610090403"},{"key":"ref19\/cit19","first-page":"1","volume-title":"xPharm: The Comprehensive Pharmacology Reference","author":"Rorabaugh B.","year":"2007"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jm049752k"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00183-7"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002121"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700607"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036619"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.52.1.745"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.045146"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.60"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e32834d9bfd"},{"key":"ref29\/cit29","unstructured":"Quinazoline-derived\n\u03b11-Adrenoceptor\nAntagonists Induce Prostate Cancer Cell Apoptosis Via an \u03b11-Adrenoceptor-independent\nAction1 | Cancer Research | American Association for Cancer Research"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.10.026"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(95)00022-S"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00249-08"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.12.010"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1994.1024"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-06-0298"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073353"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nature04541"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.03.003"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.91.3.689"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2018.12.003"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.protis.2007.08.005"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.168377"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ml5004298"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1210\/me.13.1.3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020735"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9559-y"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.07.025"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305844"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00002-X"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.2c00331","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.2c00331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T15:05:39Z","timestamp":1682521539000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.2c00331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,12]]}},"alternative-id":["10.1021\/acsinfecdis.2c00331"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.2c00331","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]}}}