{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T15:26:11Z","timestamp":1776007571194,"version":"3.50.1"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-1257"],"award-info":[{"award-number":["I-1257"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-1612"],"award-info":[{"award-number":["I-1612"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI103947"],"award-info":[{"award-number":["R01AI103947"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI155784"],"award-info":[{"award-number":["R01AI155784"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100993\/Z\/13\/Z"],"award-info":[{"award-number":["100993\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"publisher","award":["RD-08-2800"],"award-info":[{"award-number":["RD-08-2800"]}],"id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM007062"],"award-info":[{"award-number":["GM007062"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2023,3,10]]},"DOI":"10.1021\/acsinfecdis.2c00527","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T13:01:23Z","timestamp":1676034083000},"page":"527-539","source":"Crossref","is-referenced-by-count":9,"title":["Fast-Killing Tyrosine Amide ((\n                    <i>S<\/i>\n                    )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (\n                    <i>Pf<\/i>\n                    CARL)"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-4615","authenticated-orcid":true,"given":"Leah S.","family":"Imlay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloysus K.","family":"Lawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suraksha","family":"Gahalawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-9331","authenticated-orcid":true,"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-0502","authenticated-orcid":true,"given":"Chao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimisha","family":"Mittal","sequence":"additional","affiliation":[{"name":"Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-0912","authenticated-orcid":true,"given":"Sergio","family":"Wittlin","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland"},{"name":"University of Basel, 4002 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisje","family":"Churchyard","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Niederstrasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-5819","authenticated-orcid":true,"given":"Benigno","family":"Crespo-Fernandez","sequence":"additional","affiliation":[{"name":"Global Health Medicines, GlaxoSmithKline R&D, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Posner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-2882","authenticated-orcid":true,"given":"Francisco-Javier","family":"Gamo","sequence":"additional","affiliation":[{"name":"Global Health Medicines, GlaxoSmithKline R&D, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, U.K."},{"name":"School of Biomedical Sciences, University of New South Wales, Kensington, NSW 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-2113","authenticated-orcid":true,"given":"Elizabeth A.","family":"Winzeler","sequence":"additional","affiliation":[{"name":"Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-2113","authenticated-orcid":true,"given":"Beno\u00eet","family":"Laleu","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, 1215 Geneva 15, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-9581","authenticated-orcid":true,"given":"Joseph M.","family":"Ready","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-5578","authenticated-orcid":true,"given":"Margaret A.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref1\/cit1","volume-title":"World Malaria Report 2021","year":"2021"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14474"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.05.010"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1005-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101746"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032640"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa6645"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60024-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.01.011"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1675-x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00143"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4683"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.04.014"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat9446"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05777-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.06.004"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nature12782"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9735"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.015"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011560108"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.07.010"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02727-13"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.166"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1803-1806.2004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02022"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nature05572"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11901"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0962-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.096"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1101\/2022.08.23.504974"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4472"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-63"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00696-16"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00025"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00034"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211936"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4315"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.05.002"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/nature14451"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04149-14"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001169"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03265-14"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05652-0"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01163-21"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.09.141"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jm300041e"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062906"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.50"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.04.013"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15440-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2022.11.001"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3652"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00399"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030949"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz443"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602250"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.10.237"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1243"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1177\/1087057103258285"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1177\/1087057107312628"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.09.016"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/ac9912247"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00311"},{"key":"ref67\/cit67","unstructured":"Andrews, S.\n                      FastQC: A quality control tool for high throughput sequence data\n                      . 2010, https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15931.2"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1303.3997"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.4161\/fly.19695"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr670"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.2c00527","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.2c00527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T05:01:37Z","timestamp":1678424497000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.2c00527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,10]]}},"alternative-id":["10.1021\/acsinfecdis.2c00527"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.2c00527","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.10.16.512381","asserted-by":"object"}]},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}