{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:10:55Z","timestamp":1793333455127,"version":"4.5.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["162159"],"award-info":[{"award-number":["162159"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["201806047"],"award-info":[{"award-number":["201806047"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2023,9,8]]},"DOI":"10.1021\/acsinfecdis.3c00217","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:48:30Z","timestamp":1692640110000},"page":"1754-1768","source":"Crossref","is-referenced-by-count":10,"title":["Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with \u03b2-Lactam\/\u03b2-Lactamase Inhibitor Combinations against <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1021","volume":"9","author":[{"given":"Danzel Marie","family":"Ramirez","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6296-594X","authenticated-orcid":true,"given":"Christian","family":"Lozeau","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MBR3E 0W2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MBR3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-5519","authenticated-orcid":true,"given":"Frank","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, MBR3T 2N2, Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MBR3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01056-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.665759"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12033"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00071"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01781"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00077-17"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00342D"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00115-20"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10081012"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz497"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212527"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(00)00162-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa160"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky225"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00997-19"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.3.389"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2020.1767803"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00162-22"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11010101"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz228"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-019-0221-9"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127575"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11101277"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/D1MD00206F"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02055-19"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1309"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027029"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02536-13"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.04.034"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500598"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00017"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1246\/cl.210527"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01742"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jo001142e"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200150"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.1.95"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119877"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00078-18"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01293-19"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.04.021"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025247"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957050-00017"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01076-18"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00588"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.59"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00156"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00867"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2000.00971.x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027011"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00097"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931492100"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00308"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1003"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.434159"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118176"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.337"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00530-10"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24020249"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01593"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00892-19"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.074245-0"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01538-07"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt021"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00217","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:12:08Z","timestamp":1694160728000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.3c00217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,8]]}},"alternative-id":["10.1021\/acsinfecdis.3c00217"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.3c00217","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]}}}