{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:52:19Z","timestamp":1793811139421,"version":"4.6.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21EY032601"],"award-info":[{"award-number":["R21EY032601"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2023,12,8]]},"DOI":"10.1021\/acsinfecdis.3c00437","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T15:39:11Z","timestamp":1699544351000},"page":"2622-2631","source":"Crossref","is-referenced-by-count":6,"title":["High-Throughput Screen of Microbial Metabolites Identifies F<sub>1<\/sub>F<sub>O<\/sub> ATP Synthase Inhibitors as New Leads for <i>Naegleria fowleri<\/i> Infection"],"prefix":"10.1021","volume":"9","author":[{"given":"Alice","family":"Yuan","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Fong","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-9157","authenticated-orcid":true,"given":"Jennifer V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payton","family":"Norman","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Cullum","sequence":"additional","affiliation":[{"name":"Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-1735","authenticated-orcid":true,"given":"William","family":"Fenical","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"},{"name":"Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-3927","authenticated-orcid":true,"given":"Anjan","family":"Debnath","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.09.009"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809991014"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu103"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa520"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000303"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11686-021-00514-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00332.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2018.02.010"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.308"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2009.06.003"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833ed78b"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/C4NP00167B"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio841"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/md20020155"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/md17060329"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00077-22"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.71"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.055020-0"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00016-08"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112779"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023395"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/np200906s"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171112771"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0768-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112816"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74729-y"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416003-3.00008-1"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48261-7"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-020-0331-4"},{"key":"ref31\/cit31","volume-title":"Microbial Resources: from Functional Existence in Nature to Applications","author":"Kurtb\u00f6ke I.","year":"2017"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.6.1589"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2021.08.015"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.48"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.38"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.03.081"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ja01555a049"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.112228"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.56.322"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2009.32"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c06347"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.26.157"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-3031(84)80082-7"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.01.020"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00165"},{"issue":"12","key":"ref46\/cit46","first-page":"1883","volume":"56","author":"Duan X.","year":"2016","journal-title":"Weishengwu Xuebao"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006104"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00180"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00437","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:17:06Z","timestamp":1702027026000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.3c00437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,8]]}},"alternative-id":["10.1021\/acsinfecdis.3c00437"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.3c00437","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]}}}