{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:15:39Z","timestamp":1780406139182,"version":"3.54.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ70046"],"award-info":[{"award-number":["2022JJ70046"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["B202311000022"],"award-info":[{"award-number":["B202311000022"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072350"],"award-info":[{"award-number":["82072350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202591"],"award-info":[{"award-number":["82202591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2022SK2116"],"award-info":[{"award-number":["2022SK2116"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2024,4,12]]},"DOI":"10.1021\/acsinfecdis.3c00737","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T12:05:12Z","timestamp":1712145912000},"page":"1327-1338","source":"Crossref","is-referenced-by-count":8,"title":["Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus"],"prefix":"10.1021","volume":"10","author":[{"given":"Pengfei","family":"She","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-8716","authenticated-orcid":true,"given":"Yong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.027"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10010064"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ma14092427"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12721"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.296"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.63"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz620"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.01.006"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.02.002"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807213190307"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91037-9"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.9.1588"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421007"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/534314a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1468"},{"issue":"6","key":"ref18\/cit18","first-page":"725","volume":"18","author":"Amaral L.","year":"2004","journal-title":"Vivo"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00113713"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00649-2015"},{"key":"ref21\/cit21","volume-title":"Treatment of Tuberculosis: Guidelines, World Health OrganizationCopyright \u00a9 2010","author":"WHO","year":"2010"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56205"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00112-16"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/srep11596"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.032"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0525-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100909"},{"key":"ref28\/cit28","unstructured":"Hayes, J. F. Preparation of hydroxy-1-azo-derivatives as thrombopoietin mimetics for pharmaceutical use. WO2008134338, 2008."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.5b00212"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02068-20"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00286-0"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123013"},{"key":"ref33\/cit33","unstructured":"FDA, U. FDA approves lusutrombopag for thrombocytopenia in adults with chronic liver disease. 2018. https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-lusutrombopag-thrombocytopenia-adults-chronic-liver-disease. (accessed."},{"key":"ref34\/cit34","unstructured":"Agency, E. M. Lutrombopag Shionogi: summary of product characteristics. 2019. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/mulpleo. (accessed."},{"key":"ref35\/cit35","unstructured":"Agency, J. P. a. M. D. Lusutrombopag tablets 3 mg: Japanese prescribing information. 2015. https:\/\/www.pmda.go.jp\/files\/000212202.pdf. (accessed."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2017.12.005"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1705155"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800944105"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11081079"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027029"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1086\/313949"},{"key":"ref42\/cit42","unstructured":"CLSI.  Methods for Determining Bactericidal Acitivity\nof Antibacterial\nAgents; Approved Guideline. Document M26-A. 1999."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.09.011"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00073-17"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(01)80134-1"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13172"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1078-0"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S54125"},{"key":"ref49\/cit49","unstructured":"CLSI.  M100 Performance Standards for Antimicrobial Susceptibility\nTesting, 32th ed.; 2022."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b01069"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/nature26157"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0483-6"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-11878-2"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902227"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.11.019"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00884-22"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0723-z"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.08.027"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100749"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00737","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.3c00737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T08:12:13Z","timestamp":1712909533000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.3c00737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,12]]}},"alternative-id":["10.1021\/acsinfecdis.3c00737"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.3c00737","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]}}}