{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:59:40Z","timestamp":1762300780242,"version":"3.38.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI153298"],"award-info":[{"award-number":["R01 AI153298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2024,11,8]]},"DOI":"10.1021\/acsinfecdis.4c00750","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T19:16:38Z","timestamp":1730142998000},"page":"3744-3750","source":"Crossref","is-referenced-by-count":3,"title":["Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-1495","authenticated-orcid":true,"given":"Ealin N.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM)","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-6919","authenticated-orcid":true,"given":"Lucy","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM)","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-8257","authenticated-orcid":true,"given":"Hyeri","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM)","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly M.","family":"Sneller","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-6294","authenticated-orcid":true,"given":"Lisa M.","family":"Eubanks","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM)","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Tepp","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Pellet","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6759-4227","authenticated-orcid":true,"given":"Kim D.","family":"Janda","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM)","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121554"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix815"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix816"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix827"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224700"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz4197"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00261"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01006"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.2c00028"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/D1MD00089F"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/ol0603211"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.053"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01444"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00320D"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67439-y"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105832"},{"issue":"1","key":"ref18\/cit18","first-page":"67","volume":"14","author":"Kalhor M.","year":"2015","journal-title":"Iran J. Pharm. Res."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.11.010"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666191029130310"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.042"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2432"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/cc060010h"},{"key":"ref24\/cit24","unstructured":"Shine, N.; Crawford, K. R.; Eaton, L. J. A. Substrate peptides and assays for detecting and measuring proteolytic activity of serotype A neurotoxin from clostridium botulinum. US Patent 6,504,006 B1. January 7, 2003."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102172200"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ml3000403"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.03.014"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.12.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.04.019"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr354"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00487-4"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132891"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-052-7:27"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.078"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00750","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T17:23:38Z","timestamp":1740504218000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.4c00750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,8]]}},"alternative-id":["10.1021\/acsinfecdis.4c00750"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.4c00750","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"type":"print","value":"2373-8227"},{"type":"electronic","value":"2373-8227"}],"subject":[],"published":{"date-parts":[[2024,10,28]]}}}