{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:09:45Z","timestamp":1791356985459,"version":"4.3.1"},"reference-count":217,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR13522\/CoE\/34\/27\/2015"],"award-info":[{"award-number":["BT\/PR13522\/CoE\/34\/27\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR41348\/MED\/29\/1536\/2020"],"award-info":[{"award-number":["BT\/PR41348\/MED\/29\/1536\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2025,2,14]]},"DOI":"10.1021\/acsinfecdis.4c00880","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T08:01:21Z","timestamp":1737187281000},"page":"366-385","source":"Crossref","is-referenced-by-count":8,"title":["Multifunctional Mycobacterial Topoisomerases with Distinctive Features"],"prefix":"10.1021","volume":"11","author":[{"given":"Iqball","family":"Faheem","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science, C.V. Raman Avenue, Bangalore 560012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-1505","authenticated-orcid":true,"given":"Valakunja","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science, C.V. Raman Avenue, Bangalore 560012, India"},{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research","place":["Bangalore, India"]},{"name":"Indian Institute of Science Education and Research","place":["Bhopal, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm831"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000286"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.003223"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.24.8691"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn937"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bi00441a014"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05406-y"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043986"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.227059"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.33.110502.140357"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1017\/S003358350800468X"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp032"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5375.375"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02703140"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.017"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/31159"},{"issue":"4","key":"ref18\/cit18","first-page":"651","volume":"33","author":"Madhusudan K.","year":"1994","journal-title":"Biochem Mol. Biol. Int."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02715907"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04908.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.3872"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3228"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3109\/10409239109114072"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401595101"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.7.1399"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130430"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.345736"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511160200"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp586"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.12.5960"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4468"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.24.4868"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nature06396"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/379225a0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41215"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42623-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90222-4"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl5899"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.02.012"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.15.8414"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki622"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01928"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.2144"},{"issue":"6","key":"ref44\/cit44","first-page":"751","volume":"86","author":"Manjunatha U. H.","year":"2006","journal-title":"J. Indian Inst Sci."},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010245"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051489"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.15068"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/bi00564a012"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86722"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130538"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.01.004"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.345678"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012245"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks843"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq153"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq665"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001047200"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.11.024"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKN1009"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00178-2"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.064"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5318"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.18.4205"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/367138a0"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky492"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.10.004"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa201"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405891200"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.7.1668"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt506"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)37526-4"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13925"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13925"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4942"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.01.079"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.369"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100300108"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0158-x"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1038\/13283"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.08.012"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/35082615"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(00)80027-1"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.8.1830"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks780"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab239"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60526-4"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1271"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9477"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.2174\/187152607780090748"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100135"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789630947"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01617-06"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2021.1840353"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00592-22"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.049"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1086\/516116"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.658095"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407426"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315817"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.8.1004"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2160-2165.2000"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.2.471"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr566"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.529164"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01380-07"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1021\/bi5000564"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1892"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525055113"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525047113"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00250-06"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.854-862.2003"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.839"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1021\/bi00435a038"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01958-13"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4838"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-057-8:171"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1805-1815.2002"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.4.479"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.50.35927"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01738"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02100-16"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00564-22"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01263-21"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03913-14"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00035"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01750"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.3c00012"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00021"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02192-21"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1186\/s44263-024-00087-w"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700721114"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01102-7"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.12.4474"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.10.4838"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.9.1655"},{"issue":"2","key":"ref136\/cit136","first-page":"510","volume":"51","author":"Eder J. P.","year":"1991","journal-title":"Cancer Res."},{"issue":"4","key":"ref137\/cit137","first-page":"256","volume":"6","author":"Murren J. R.","year":"2000","journal-title":"Cancer J."},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.19.5449-5456.2002"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKV1088"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00596-06"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01208-21"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1021\/bi982320p"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016705118"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2007.01005.x"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn355"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl704"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1357"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90629-X"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340010305"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf038"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-003-0598-4"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1021\/bi052130w"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1101\/gad.241984.114"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02077.x"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.03.049"},{"key":"ref156\/cit156","unstructured":"Manjunatha, U. H.; Roy, B. N.; Nagaraja, V. Monoclonal Antibody Derived Peptide Inhibitors for Mycobacterial Dna Gyrase. AU-2002347586-A1, September 20, 2002. https:\/\/pubchem.ncbi.nlm.nih.gov\/patent\/AU-2002347586-A1."},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.11.006"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231275498"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1099\/MIC.0.000014"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12412"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02261-4"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2009.05.004"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08398.x"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226118"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.03.029"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01592"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19944-4"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01659"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.148148"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0207733"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01696-17"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0202749"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04516-14"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00008-9"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1006754"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7024"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-019-0211-6"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.05.067"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1999.00296.x"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.12.4185"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14689"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1128\/jb.162.1.78-84.1985"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.10.001"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.19.5999-6006.1994"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1007\/BF02717907"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01358.x"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1099\/MIC.0.038620-0"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0043900"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00530-16"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.12.6871-6874.1990"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.241390.x"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.0901"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05569.x"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.05.004"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00673"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419069"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMCL.2013.12.080"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1021\/JM401268F"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01751-13"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00511"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa286"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1021\/cb300510w"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116693"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c01390"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.8.2084"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/34.3.343"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90010-7"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1021\/jm500432n"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01514-21"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00863"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110967"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04412-1"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.11.027"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00288-16"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1447-1454.2005"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1032320"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-022-00503-z"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00880","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T08:07:21Z","timestamp":1752826041000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.4c00880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":217,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,14]]}},"alternative-id":["10.1021\/acsinfecdis.4c00880"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.4c00880","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]}}}