{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:54:17Z","timestamp":1793843657175,"version":"4.6.1"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI049313"],"award-info":[{"award-number":["R01 AI049313"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI071155"],"award-info":[{"award-number":["R01 AI071155"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104785\/B\/14\/Z"],"award-info":[{"award-number":["104785\/B\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UP_1202\/11"],"award-info":[{"award-number":["MC_UP_1202\/11"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UP_A253_1111"],"award-info":[{"award-number":["MC_UP_A253_1111"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/21232-1"],"award-info":[{"award-number":["2011\/21232-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/14957-5"],"award-info":[{"award-number":["2013\/14957-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["99999.003125\/2014-09"],"award-info":[{"award-number":["99999.003125\/2014-09"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["140079\/2013-0"],"award-info":[{"award-number":["140079\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Francis Crick Institute","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mechanisms that lead to phenotypic antibacterial tolerance in bacteria remain poorly understood. We investigate whether changes in NaCl concentration toward physiologically higher values affect antibacterial efficacy against Mycobacterium tuberculosis (Mtb), the causal agent of human tuberculosis. Indeed, multiclass phenotypic antibacterial tolerance is observed during Mtb growth in physiologic saline. This includes changes in sensitivity to ethionamide, ethambutol, d-cycloserine, several aminoglycosides, and quinolones. By employing organism-wide metabolomic and lipidomic approaches combined with phenotypic tests, we identified a time-dependent biphasic adaptive response after exposure of Mtb to physiological levels of NaCl. A first rapid, extensive, and reversible phase was associated with changes in core and amino acid metabolism. In a second phase, Mtb responded with a substantial remodelling of plasma membrane and outer lipid membrane composition. We demonstrate that phenotypic tolerance at physiological concentrations of NaCl is the result of changes in plasma and outer membrane lipid remodeling and not changes in core metabolism. Altogether, these results indicate that physiologic saline-induced antibacterial tolerance is kinetically coupled to cell envelope changes and demonstrate that metabolic changes and growth arrest are not the cause of phenotypic tolerance observed in Mtb exposed to physiologic concentrations of NaCl. Importantly, this work uncovers a role for bacterial cell envelope remodeling in antibacterial tolerance, alongside well-documented allterations in respiration, metabolism, and growth rate.<\/jats:p>","DOI":"10.1021\/acsinfecdis.5b00148","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T21:11:36Z","timestamp":1459199496000},"page":"352-360","source":"Crossref","is-referenced-by-count":55,"title":["Cell-Envelope Remodeling as a Determinant of Phenotypic\nAntibacterial Tolerance in\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1021","volume":"2","author":[{"given":"Ge\u0301rald","family":"Larrouy-Maumus","sequence":"first","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]},{"name":"Imperial College London , , Kensington, ,","place":["London, United Kingdom, SW7\u00a02DD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo B.","family":"Marino","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]},{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Araraquara, SP, Brazil, 4801-902"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashoka V. R.","family":"Madduri","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School , , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Ragan","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie M.","family":"Hunt","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Bassano","sequence":"additional","affiliation":[{"name":"Imperial College London , , Kensington, ,","place":["London, United Kingdom, SW7\u00a02DD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano G.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Branch","family":"Moody","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School , , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando R.","family":"Pavan","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Araraquara, SP, Brazil, 4801-902"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Pedro S.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , , Mill Hill Laboratory, ,","place":["London, United Kingdom, NW7\u00a01AA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"2026090216313088000_cit1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/nrmicro1445","article-title":"Non-inherited antibiotic\nresistance","volume":"4","author":"Levin","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"2026090216313088000_cit2","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1574-6976.2011.00282.x","article-title":"Metabolic regulation\nof antibiotic resistance","volume":"35","author":"Martinez","year":"2011","journal-title":"FEMS Microbiol Rev."},{"key":"2026090216313088000_cit3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fcimb.2014.00099","article-title":"Staphylococcus aureus small colony variants (SCVs): a road map for the metabolic\npathways involved in persistent infections","volume":"4","author":"Proctor","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026090216313088000_cit4","doi-asserted-by":"publisher","first-page":"8173","DOI":"10.1073\/pnas.1509743112","article-title":"Antibiotic efficacy is linked to bacterial cellular\nrespiration","volume":"112","author":"Lobritz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit5","doi-asserted-by":"publisher","first-page":"8172","DOI":"10.1128\/JB.186.24.8172-8180.2004","article-title":"Specialized persister cells and the\nmechanism of multidrug tolerance in Escherichia coli","volume":"186","author":"Keren","year":"2004","journal-title":"J. Bacteriol."},{"key":"2026090216313088000_cit6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1128\/jb.155.2.768-775.1983","article-title":"hipA, a newly recognized\ngene of Escherichia coli K-12 that affects frequency\nof persistence after inhibition of murein synthesis","volume":"155","author":"Moyed","year":"1983","journal-title":"J. Bacteriol."},{"key":"2026090216313088000_cit7","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1185449","article-title":"The population\ndynamics and control of tuberculosis","volume":"328","author":"Dye","year":"2010","journal-title":"Science"},{"key":"2026090216313088000_cit8","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/j.1462-5822.2009.01335.x","article-title":"Mycobacterial\nsurvival strategies in the phagosome: defence against host stresses","volume":"11","author":"Ehrt","year":"2009","journal-title":"Cell. Microbiol."},{"key":"2026090216313088000_cit9","doi-asserted-by":"publisher","first-page":"e1003282","DOI":"10.1371\/journal.ppat.1003282","article-title":"Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status\nof its host cell","volume":"9","author":"Tan","year":"2013","journal-title":"PLoS Pathog."},{"key":"2026090216313088000_cit10","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S1097-2765(00)80284-1","article-title":"Loss of CFTR chloride channels alters\nsalt absorption by cystic fibrosis airway epithelia in vitro","volume":"2","author":"Zabner","year":"1998","journal-title":"Mol. Cell"},{"key":"2026090216313088000_cit11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrn2400","article-title":"Central mechanisms of osmosensation and systemic osmoregulation","volume":"9","author":"Bourque","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090216313088000_cit12","doi-asserted-by":"publisher","first-page":"E5069","DOI":"10.1073\/pnas.1321205110","article-title":"Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser\/Thr protein kinase","volume":"110","author":"Hatzios","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit13","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1128\/AAC.38.9.2054","article-title":"Metronidazole is\nbactericidal to dormant cells of Mycobacterium tuberculosis","volume":"38","author":"Wayne","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090216313088000_cit14","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.biopha.2011.04.021","article-title":"Drug resistance in Mycobacterium tuberculosis clinical isolates from Brazil: phenotypic and\ngenotypic methods","volume":"65","author":"Miyata","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"2026090216313088000_cit15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-59745-246-5_14","article-title":"Flow cytometry of bacterial membrane\npotential and permeability","volume":"142","author":"Shapiro","year":"2008","journal-title":"Methods Mol. Med."},{"key":"2026090216313088000_cit16","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1021\/ml200157f","article-title":"Nitazoxanide disrupts membrane potential and intrabacterial\npH homeostasis of Mycobacterium tuberculosis","volume":"2","author":"de Carvalho","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"2026090216313088000_cit17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1574-6976.2002.tb00598.x","article-title":"Bacterial osmoadaptation: the role of osmolytes in bacterial stress\nand virulence","volume":"26","author":"Sleator","year":"2002","journal-title":"FEMS Microbiol Rev."},{"key":"2026090216313088000_cit18","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1093\/pcp\/pcd005","article-title":"Responses of wild watermelon\nto drought stress: accumulation of an ArgE homologue and citrulline\nin leaves during water deficits","volume":"41","author":"Kawasaki","year":"2000","journal-title":"Plant Cell\nPhysiol."},{"key":"2026090216313088000_cit19","doi-asserted-by":"publisher","first-page":"253414","DOI":"10.1155\/2013\/253414","article-title":"Citrulline\nis an important biochemical indicator in tolerance to saline and drought\nstresses in melon","volume":"2013","author":"Kusvuran","year":"2013","journal-title":"Sci. World J."},{"key":"2026090216313088000_cit20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1095-6433(01)00442-1","article-title":"Osmosensing and osmoregulatory compatible solute accumulation\nby bacteria","volume":"130","author":"Wood","year":"2001","journal-title":"Comp. Biochem. Physiol., Part A:\nMol. Integr. Physiol."},{"key":"2026090216313088000_cit21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the\nbiology of Mycobacterium tuberculosis from the complete\ngenome sequence","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"2026090216313088000_cit22","doi-asserted-by":"publisher","first-page":"12652","DOI":"10.1073\/pnas.1003063107","article-title":"Osmotically induced synthesis of the dipeptide N-acetylglutaminylglutamine amide is mediated by a new pathway\nconserved among bacteria","volume":"107","author":"Sagot","year":"2010","journal-title":"Proc. Natl. Acad.\nSci. U.S.A."},{"key":"2026090216313088000_cit23","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.chembiol.2010.08.009","article-title":"Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates","volume":"17","author":"de Carvalho","year":"2010","journal-title":"Chem. Biol."},{"key":"2026090216313088000_cit24","doi-asserted-by":"publisher","first-page":"11320","DOI":"10.1073\/pnas.1221597110","article-title":"Discovery\nof a glycerol 3-phosphate phosphatase reveals glycerophospholipid\npolar head recycling in Mycobacterium tuberculosis","volume":"110","author":"Larrouy-Maumus","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit25","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1073\/pnas.1219375110","article-title":"Multifunctional\nessentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis","volume":"110","author":"Eoh","year":"2013","journal-title":"Proc.\nNatl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit26","doi-asserted-by":"publisher","first-page":"e1002287","DOI":"10.1371\/journal.ppat.1002287","article-title":"Fumarate reductase activity maintains\nan energized membrane in anaerobic Mycobacterium tuberculosis","volume":"7","author":"Watanabe","year":"2011","journal-title":"PLoS Pathog."},{"key":"2026090216313088000_cit27","doi-asserted-by":"publisher","first-page":"4976","DOI":"10.1073\/pnas.1400390111","article-title":"Methylcitrate cycle defines the bactericidal essentiality\nof isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids","volume":"111","author":"Eoh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit28","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.bbamem.2009.06.010","article-title":"Cardiolipin\nand the osmotic stress responses of bacteria","volume":"1788","author":"Romantsov","year":"2009","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"2026090216313088000_cit29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/07388559709146608","article-title":"Effect of some environmental factors\non the content and composition of microbial membrane lipids","volume":"17","author":"Sajbidor","year":"1997","journal-title":"Crit. Rev. Biotechnol."},{"key":"2026090216313088000_cit30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1099\/mic.0.28345-0","article-title":"Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity","volume":"152","author":"Lopez","year":"2006","journal-title":"Microbiology"},{"key":"2026090216313088000_cit31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s002849900279","article-title":"Variations of the envelope composition of Bacillus subtilis during growth in hyperosmotic medium","volume":"36","author":"Lopez","year":"1998","journal-title":"Curr. Microbiol."},{"key":"2026090216313088000_cit32","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.syapm.2005.03.014","article-title":"Contribution\nof chemical changes in membrane lipids to the osmoadaptation of the\nhalophilic bacterium Chromohalobacter salexigens","volume":"28","author":"Vargas","year":"2005","journal-title":"Syst. Appl. Microbiol."},{"key":"2026090216313088000_cit33","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1104\/pp.125.4.1842","article-title":"Unsaturated fatty acids in membrane lipids protect\nthe photosynthetic machinery against salt-induced damage in Synechococcus","volume":"125","author":"Allakhverdiev","year":"2001","journal-title":"Plant Physiol."},{"key":"2026090216313088000_cit34","doi-asserted-by":"publisher","first-page":"16643","DOI":"10.1074\/jbc.M110.119263","article-title":"Stress-induced synthesis of phosphatidylinositol\n3-phosphate in mycobacteria","volume":"285","author":"Morita","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2026090216313088000_cit35","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.chembiol.2011.10.013","article-title":"A comparative lipidomics platform for chemotaxonomic\nanalysis of Mycobacterium tuberculosis","volume":"18","author":"Layre","year":"2011","journal-title":"Chem. Biol."},{"key":"2026090216313088000_cit36","doi-asserted-by":"publisher","first-page":"21257","DOI":"10.1074\/jbc.M400324200","article-title":"The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis","volume":"279","author":"Domenech","year":"2004","journal-title":"J. Biol.\nChem."},{"key":"2026090216313088000_cit37","doi-asserted-by":"publisher","first-page":"4958","DOI":"10.1073\/pnas.1403078111","article-title":"Mycobacterial outer membrane is a lipid bilayer and\nthe inner membrane is unusually rich in diacyl phosphatidylinositol\ndimannosides","volume":"111","author":"Bansal-Mutalik","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090216313088000_cit38","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/j.1365-2958.2011.07535.x","article-title":"Hydroxylated ornithine lipids increase\nstress tolerance in Rhizobium tropici CIAT899","volume":"79","author":"Vences-Guzman","year":"2011","journal-title":"Mol. Microbiol."},{"key":"2026090216313088000_cit39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0006-3002(63)90727-3","article-title":"[On the presence\nof ornithine in bacterial lipids]","volume":"70","author":"Laneelle","year":"1963","journal-title":"Biochim.\nBiophys. Acta"},{"key":"2026090216313088000_cit40","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1099\/00221287-136-4-773","article-title":"Ornithine lipid\nof Mycobacterium tuberculosis: its distribution in\nsome slow- and fast-growing mycobacteria","volume":"136","author":"Laneelle","year":"1990","journal-title":"J.\nGen. Microbiol."},{"key":"2026090216313088000_cit41","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nchembio.1437","article-title":"Ubiquinone accumulation improves\nosmotic-stress tolerance in Escherichia coli","volume":"10","author":"Sevin","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"2026090216313088000_cit42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nature12337","article-title":"The Mycobacterium tuberculosis regulatory network and hypoxia","volume":"499","author":"Galagan","year":"2013","journal-title":"Nature"},{"key":"2026090216313088000_cit43","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/cmi.12214","article-title":"Multiple deletions in the polyketide\nsynthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen\ninteractions","volume":"16","author":"Passemar","year":"2014","journal-title":"Cell. Microbiol."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5b00148","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/2\/5\/352\/67003646\/acsinfecdis.5b00148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/2\/5\/352\/67003646\/acsinfecdis.5b00148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:31:39Z","timestamp":1788381099000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/2\/5\/352\/788310\/Cell-Envelope-Remodeling-as-a-Determinant-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,28]]},"published-print":{"date-parts":[[2016,5,13]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5b00148","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}