{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:01:55Z","timestamp":1792875715940,"version":"4.5.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100029479","name":"Medicinal Chemistry Division, American Chemical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["TL1 DK136047"],"award-info":[{"award-number":["TL1 DK136047"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI088025"],"award-info":[{"award-number":["R01 AI088025"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM119426"],"award-info":[{"award-number":["R35 GM119426"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2025,8,8]]},"DOI":"10.1021\/acsinfecdis.5c00297","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T15:07:34Z","timestamp":1752246454000},"page":"2276-2286","source":"Crossref","is-referenced-by-count":9,"title":["Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-6092","authenticated-orcid":true,"given":"Debayan","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Biochemistry","place":["Atlanta, United States"]},{"name":"Emory University School of Medicine","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Deprez","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Atlanta, United States"]},{"name":"Emory University","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-051X","authenticated-orcid":true,"given":"Natalia","family":"Zelinskaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry","place":["Atlanta, United States"]},{"name":"Emory University School of Medicine","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-4475","authenticated-orcid":true,"given":"Jose M.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry","place":["Atlanta, United States"]},{"name":"Emory University School of Medicine","place":["Atlanta, United States"]},{"name":"Graduate Program in Biochemistry, Cell and Developmental Biology (BCDB)","place":["Atlanta, United States"]},{"name":"Emory University","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-7744","authenticated-orcid":true,"given":"William M.","family":"Wuest","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Atlanta, United States"]},{"name":"Emory University","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-380X","authenticated-orcid":true,"given":"Graeme L.","family":"Conn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry","place":["Atlanta, United States"]},{"name":"Emory University School of Medicine","place":["Atlanta, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101310"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131946"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111615"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027029"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp-0002-2018"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/life12121949"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1177\/2049936120952604"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12050860"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy613"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00313-18"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12091164"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00926-07"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1086\/518605"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.05.001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402789111"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011181"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2304128120"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00459C"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2020.06.002"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06066-11"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2024.107382"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01009-21"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070906"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky420"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq627"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4675"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuz014"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae201"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04876-22"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306430"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00302"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00578"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s44259-023-00013-4"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(86)90441-9"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00077-17"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2010.07.005"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00297","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:12:01Z","timestamp":1754640721000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,8]]}},"alternative-id":["10.1021\/acsinfecdis.5c00297"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5c00297","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]}}}