{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:11:14Z","timestamp":1791825074033,"version":"4.3.4"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["302348\/2025-5"],"award-info":[{"award-number":["302348\/2025-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["307829\/2021-9"],"award-info":[{"award-number":["307829\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["312211\/2021-0"],"award-info":[{"award-number":["312211\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2023\/03485-7"],"award-info":[{"award-number":["2023\/03485-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2023\/17755-6"],"award-info":[{"award-number":["2023\/17755-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2025,10,10]]},"DOI":"10.1021\/acsinfecdis.5c00634","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:08:55Z","timestamp":1759309735000},"page":"2871-2881","source":"Crossref","is-referenced-by-count":12,"title":["Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against <i>Angiostrongylus cantonensis<\/i>"],"prefix":"10.1021","volume":"11","author":[{"given":"Bruna L.","family":"Lemes","sequence":"first","affiliation":[{"name":"Research Center on Neglected Diseases","place":["Guarulhos, Brazil"]},{"name":"Guarulhos University","place":["Guarulhos, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A.","family":"Siegl-Breno","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Diadema, Brazil"]},{"name":"Federal University of S\u00e3o Paulo","place":["Diadema, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaelly K.","family":"Silva-Nunes","sequence":"additional","affiliation":[{"name":"Research Center on Neglected Diseases","place":["Guarulhos, Brazil"]},{"name":"Guarulhos University","place":["Guarulhos, Brazil"]},{"name":"Research Center on Neglected Diseases, Scientific and Technological Institute","place":["S\u00e3o Paulo, Brazil"]},{"name":"Brazil University","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia B.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Diadema, Brazil"]},{"name":"Federal University of S\u00e3o Paulo","place":["Diadema, Brazil"]},{"name":"Department of Medicine","place":["S\u00e3o Paulo, Brazil"]},{"name":"Federal University of S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Research Center on Neglected Diseases, Scientific and Technological Institute","place":["S\u00e3o Paulo, Brazil"]},{"name":"Brazil University","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia E. P.","family":"Motta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Diadema, Brazil"]},{"name":"Federal University of S\u00e3o Paulo","place":["Diadema, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":true,"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Research Center on Neglected Diseases","place":["Guarulhos, Brazil"]},{"name":"Guarulhos University","place":["Guarulhos, Brazil"]},{"name":"Research Center on Neglected Diseases, Scientific and Technological Institute","place":["S\u00e3o Paulo, Brazil"]},{"name":"Brazil University","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-273X","authenticated-orcid":true,"given":"Jo\u00e3o Paulo S.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Diadema, Brazil"]},{"name":"Federal University of S\u00e3o Paulo","place":["Diadema, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115268"},{"key":"ref2\/cit2","volume-title":"Assessing Schistosomiasis and Soil-Transmitted Helminthiases Control Programmes: Monitoring and Evaluation Framework","author":"WHO W. H. O.","year":"2024","edition":"1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006837"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.04.004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2051477"},{"key":"ref6\/cit6","volume-title":"Ending the Neglect to Attain the Sustainable Development Goals: A Framework for Monitoring and Evaluating Progress of the Road Map for Neglected Tropical Diseases 2021\u20132030","author":"WHO","year":"2020","edition":"1"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000481"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.22-0360"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.012"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.04.021"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c04773"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad944"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab730"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003932"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89434-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)43508-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201801364"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c06977"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/chemistry7040105"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01208-19"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01722-18"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04140-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88484-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s10158-008-0068-4"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.04.006"},{"key":"ref27\/cit27","first-page":"450","volume-title":"Fundamentos de Qu\u00edmica Farmac\u00eautica Medicinal","author":"Fernandes J. P. S.","year":"2022"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33880-y"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1588533"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-011-9556-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805611"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2016.08.008"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600182"},{"issue":"1","key":"ref34\/cit34","first-page":"9","volume":"4","author":"Hammer \u00d8.","year":"2001","journal-title":"Palaeontol. Electron."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.53393\/rial.1954.14.33246"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.901459"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05150"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156045"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00634","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:12:43Z","timestamp":1760083963000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,10]]}},"alternative-id":["10.1021\/acsinfecdis.5c00634"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5c00634","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}