{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:16:26Z","timestamp":1765530986163,"version":"3.48.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203134\/Z\/16\/Z"],"award-info":[{"award-number":["203134\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["224024\/Z\/21\/Z"],"award-info":[{"award-number":["224024\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tres Cantos Open Lab Foundation","award":["TC314"],"award-info":[{"award-number":["TC314"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2025,12,12]]},"DOI":"10.1021\/acsinfecdis.5c00681","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:30:16Z","timestamp":1764570616000},"page":"3529-3541","source":"Crossref","is-referenced-by-count":0,"title":["Humanization of Drug Metabolism in the\n                    <i>Plasmodium berghei<\/i>\n                    Mouse Model for Antimalarial Drug Discovery"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-1178","authenticated-orcid":true,"given":"A. Kenneth","family":"MacLeod","sequence":"first","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Merino","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Viera-Morilla","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Frame","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Tavendale","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Duncan","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika G.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R. C.","family":"Simeons","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Gomez-Jimenez","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Bel\u00e9n","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Riley","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Shishikura","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Santos","family":"Mart\u00ednez- Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Roland","family":"Wolf","sequence":"additional","affiliation":[{"name":"Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-0130","authenticated-orcid":true,"given":"Kevin D.","family":"Read","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences","place":["Dundee, U.K."]},{"name":"University of Dundee","place":["Dundee, U.K."]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organisation.\n                      World Malaria Report\n                      2024."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu491"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02706-5"},{"key":"ref5\/cit5","unstructured":"Medicines\nfor Malaria Venture.\n                      Annual Report\n                      2023."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013000991"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00081-B"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80088-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.6.2265"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02550"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0207"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00519-09"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.086397"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.487"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1851"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00750-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315069121"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.122987.1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10554"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4200"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066967"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90285-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13148"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976712"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.6.748"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199631040-00003"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0637-8"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)21293-9"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3109\/00498258109045277"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)37145-9"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.810-820.2001"},{"volume-title":"Handbook of Animal Models of Infection","year":"1999","author":"Peters W.","key":"ref33\/cit33"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.26.4.313"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.9.1005"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-2993(99)80010-4"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02369.x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11239-0"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-212"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.116.073437"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham H.","year":"2016"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00681","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:12:28Z","timestamp":1765530748000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,12]]}},"alternative-id":["10.1021\/acsinfecdis.5c00681"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5c00681","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"type":"print","value":"2373-8227"},{"type":"electronic","value":"2373-8227"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}