{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:14:29Z","timestamp":1783689269578,"version":"3.55.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["F30DE030334"],"award-info":[{"award-number":["F30DE030334"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE022350"],"award-info":[{"award-number":["R01DE022350"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE028329"],"award-info":[{"award-number":["R01DE028329"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21DA059844"],"award-info":[{"award-number":["R21DA059844"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21DE028349"],"award-info":[{"award-number":["R21DE028349"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2026,7,10]]},"DOI":"10.1021\/acsinfecdis.5c00767","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:51:42Z","timestamp":1782924702000},"page":"2188-2202","source":"Crossref","is-referenced-by-count":0,"title":["Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation in\n                    <i>Streptococcus mutans<\/i>"],"prefix":"10.1021","volume":"12","author":[{"given":"Edwin M.","family":"Rojas","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]},{"name":"School of Dentistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Govindan","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvathy","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soniya","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomaterial and Biomedical Sciences, School of Dentistry","place":["Portland, United States"]},{"name":"Oregon Health & Science University","place":["Portland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biomaterial and Biomedical Sciences, School of Dentistry","place":["Portland, United States"]},{"name":"Oregon Health & Science University","place":["Portland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7977-2295","authenticated-orcid":true,"given":"Tyrese","family":"Boddie","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-4053","authenticated-orcid":true,"given":"Hui-Ting","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-3954","authenticated-orcid":true,"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomaterial and Biomedical Sciences, School of Dentistry","place":["Portland, United States"]},{"name":"Oregon Health & Science University","place":["Portland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-2378","authenticated-orcid":true,"given":"Sadanandan E.","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]},{"name":"Global Center for Craniofacial Oral and Dental Disorders","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]},{"name":"Center for Clinical and Translational Sciences","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-021-3775-4"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9070569"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56679-2"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.gpp1123-0051-2018"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-1-3-37"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601206010023"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.413"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v8.31095"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00919-15"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nri1857"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00272"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2024.09.006"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00373"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.06.033"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39125-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00137-1"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06168-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11111635"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00462-18"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/femsml\/uqad043"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105264"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13277"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00023-23"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02418-23"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115943"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052413"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.05.042"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6492346"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020250"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11080752"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.056"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01254"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0321-6"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2174\/1871520616666160902094739"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50170-9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/384815"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jf0532462"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103672"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.3872"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01728.x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2022.2055523"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.305"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112757"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-014-1056-2"},{"key":"ref45\/cit45","unstructured":"BioSolveIT\n                      BioSolveIT GmbH, SeeSAR version\n13.0.1.\n                      2023, Sankt Augustin: Germany."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1145\/1656274.1656280"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009246"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01496-10"},{"key":"ref49\/cit49","unstructured":"GraphPad Software\n                      GraphPad Prism Version\n10.3.0 for Windows.\n                      GraphPad Software 2024."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ie071452o"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.31083\/ph.2009.9163"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104342"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00767","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:23:30Z","timestamp":1783686210000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,10]]}},"alternative-id":["10.1021\/acsinfecdis.5c00767"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5c00767","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}