{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:00:51Z","timestamp":1787000451023,"version":"build-2736575974"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI126874"],"award-info":[{"award-number":["AI126874"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2026,1,9]]},"DOI":"10.1021\/acsinfecdis.5c00798","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:22:31Z","timestamp":1767032551000},"page":"298-313","source":"Crossref","is-referenced-by-count":2,"title":["Broad-Spectrum Activity of Peptide-Linked Amikacin Conjugates in Synergy with Polymyxin B against Extensively Drug-Resistant and Pandrug-Resistant Bacteria"],"prefix":"10.1021","volume":"12","author":[{"given":"Sandra","family":"Story","sequence":"first","affiliation":[{"name":"NUBAD, LLC","place":["Greenville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Department of Chemistry","place":["Clemson, United States"]},{"name":"Clemson University","place":["Clemson, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnagopal","family":"Maiti","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Department of Chemistry","place":["Clemson, United States"]},{"name":"Clemson University","place":["Clemson, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-1066","authenticated-orcid":true,"given":"Dev P.","family":"Arya","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Department of Chemistry","place":["Clemson, United States"]},{"name":"Clemson University","place":["Clemson, United States"]},{"name":"NUBAD, LLC","place":["Greenville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93308-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1128\/mr.51.3.341-350.1987"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5291.1367"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1552"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","DOI":"10.1002\/9780470149676","volume-title":"Aminoglycoside Antibiotics: From Chemical Biology To Drug Discovery","author":"Arya D. P.","year":"2007"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.43.100189.001231"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/9781555815615.ch16"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00034"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01304-15"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122267"},{"issue":"01","key":"ref14\/cit14","first-page":"27","volume":"12","author":"Aishwarya K. V. L.","year":"2020","journal-title":"JLB"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.05.002"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.03.038"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00660-12"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2949-2953.2005"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12091164"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00459C"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S483450"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017224"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab381"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1266"},{"issue":"4","key":"ref25\/cit25","first-page":"55","volume":"60","author":"Kuzovlev A.","year":"2015","journal-title":"Anesteziol. Reanimatol."},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13594"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006323"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.04.014"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01587-19"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.10.010"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00246-20"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2184346"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2025.105780"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S161636"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/cb5010367"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00861-15"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00427F"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00176"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.022"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00446"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020284"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202002258"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/b100446"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1081\/CAR-200059973"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00092A"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00165F"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2019.05.027"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/open.202400189"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bi401088n"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00060"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.022"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9216-4_9"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00254"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00703"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.10.076"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC01969A"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules181114228"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.07.079"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1039\/b108171c"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/bi9016796"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2018.07.012"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1605813"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-021-02510-0"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.2c00467"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c02071"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01039-15"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.16.5244-5246.1991"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14403"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.275578"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16373-0_5"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00834-10"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.28"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00193"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031832"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402175"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00798","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.5c00798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:16:02Z","timestamp":1768569362000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"alternative-id":["10.1021\/acsinfecdis.5c00798"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.5c00798","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]}}}