{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:15:37Z","timestamp":1788423337557,"version":"build-2803163510"},"reference-count":11,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current explosive epidemic of Zika virus in South and Central America, as well as the Caribbean, poses a global public health emergency. Here we comment on the challenges on development of better diagnosis and potential therapeutics and vaccine for Zika virus.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6b00030","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T08:01:39Z","timestamp":1456992099000},"page":"170-172","source":"Crossref","is-referenced-by-count":75,"title":["Zika Virus: Diagnosis, Therapeutics, and Vaccine"],"prefix":"10.1021","volume":"2","author":[{"given":"Chao","family":"Shan","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuping","family":"Xie","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D. T.","family":"Barrett","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano A.","family":"Garcia-Blanco","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Tesh","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Fernando da Costa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Vasilakis","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Weaver","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yong","family":"Shi","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , , , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"issue":"5","key":"2026090303540687200_cit1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"10014","key":"2026090303540687200_cit2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0140-6736(16)00014-3","article-title":"Zika virus: a new global threat for 2016","volume":"387","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"2026090303540687200_cit3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of\nZika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerging Infect. Dis."},{"key":"2026090303540687200_cit4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1056\/NEJMp1600297","article-title":"Zika Virus in the\nAmericas - Yet Another Arbovirus Threat","volume":"374","author":"Fauci","year":"2016","journal-title":"N.\nEngl. J. Med."},{"issue":"8","key":"2026090303540687200_cit5","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated\nwith an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerging Infect. Dis."},{"issue":"9","key":"2026090303540687200_cit6","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1128\/JCM.41.9.4217-4223.2003","article-title":"Immunoassay\ntargeting nonstructural protein 5 to differentiate West Nile virus\ninfection from dengue and St. Louis encephalitis virus infections\nand from flavivirus vaccination","volume":"41","author":"Wong","year":"2003","journal-title":"J. Clin Microbiol"},{"issue":"290","key":"2026090303540687200_cit7","doi-asserted-by":"publisher","first-page":"290ra89","DOI":"10.1126\/scitranslmed.aaa5597","article-title":"A screen of approved drugs and molecular probes identifies\ntherapeutics with anti-Ebola virus activity","volume":"7","author":"Johansen","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"16","key":"2026090303540687200_cit8","doi-asserted-by":"publisher","first-page":"8233","DOI":"10.1128\/JVI.00855-15","article-title":"Discovery of Dengue Virus NS4B Inhibitors","volume":"89","author":"Wang","year":"2015","journal-title":"J. Virol."},{"issue":"2","key":"2026090303540687200_cit9","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.antiviral.2013.09.013","article-title":"Ten years of dengue drug discovery: Progress and prospects","volume":"100","author":"Lim","year":"2013","journal-title":"Antiviral Res."},{"issue":"48","key":"2026090303540687200_cit10","doi-asserted-by":"publisher","first-page":"20435","DOI":"10.1073\/pnas.0907010106","article-title":"An adenosine\nnucleoside inhibitor of dengue virus","volume":"106","author":"Yin","year":"2009","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."},{"issue":"50","key":"2026090303540687200_cit11","doi-asserted-by":"publisher","first-page":"7100","DOI":"10.1016\/j.vaccine.2015.09.108","article-title":"Development of the Sanofi Pasteur\ntetravalent dengue vaccine: One more step forward","volume":"33","author":"Guy","year":"2015","journal-title":"Vaccine"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6b00030","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/2\/3\/170\/67182741\/acsinfecdis.6b00030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/2\/3\/170\/67182741\/acsinfecdis.6b00030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:54:14Z","timestamp":1788422054000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/2\/3\/170\/788242\/Zika-Virus-Diagnosis-Therapeutics-and-Vaccine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,3]]},"published-print":{"date-parts":[[2016,3,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6b00030","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]}}}