{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:20:22Z","timestamp":1772763622524,"version":"3.50.1"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"11","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Li Ka Shing Applied Virology Institute"},{"name":"Li Ka Shing Institute of Virology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2016,11,11]]},"DOI":"10.1021\/acsinfecdis.6b00113","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T20:04:54Z","timestamp":1470254694000},"page":"872-881","source":"Crossref","is-referenced-by-count":10,"title":["A Comprehensive Computational Analysis for the Binding Modes of Hepatitis C Virus NS5A Inhibitors: The Question of Symmetry"],"prefix":"10.1021","volume":"2","author":[{"given":"Marawan","family":"Ahmed","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Pal","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology, Kharagpur, West Bengal 721302, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Houghton","sequence":"additional","affiliation":[{"name":"Li Ka Shing Institute of Virology, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"},{"name":"Li Ka Shing Applied Virology Institute, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Barakat","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"},{"name":"Li Ka Shing Institute of Virology, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"},{"name":"Li Ka Shing Applied Virology Institute, University of Alberta, 116 Street & 85 Avenue, Edmonton, Alberta, Canada T6G\u202f2R3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405880-4.00005-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2431"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.03.011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.08.019"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02411.x"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02639-15"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S36247"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02788-14"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nature15711"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3046"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i11.2902"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/srep04765"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122844"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-424-7_18"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jm4013104"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ci400631n"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jm501291c"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jm401398x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm401499g"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/v6114227"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404761200"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2456"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2011.036.09.1641618"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2011.05.010"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.029"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nature08960"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.05.015"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00556-10"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130022"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05977-11"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134395"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.06.014"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1586"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.35.040405.102134"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201600231"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-013-9644-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis761"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-012-9570-1"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ci049915d"},{"key":"ref40\/cit40","unstructured":"Case, D. A., Darden, T. A., Cheatham, T. E., Simmerling, C. L., Wang, J., Duke, R. E., Luo, R., Walker, R. C., Zhang, W., Merz, K. M., Roberts, B., Hayik, S., Roitberg, A., Seabra, G., Swails, J., Goetz, A. W., Kolossv\u00e1ry, I., Wong, K. F., Paesani, F., Vanicek, J., Wolf, R. M., Liu, J., Wu, X., Brozell, S. R., Steinbrecher, T., Gohlke, H., Cai, Q., Ye, X., Wang, J., Hsieh, M. J., Cui, G., Roe, D. R., Mathews, D. H., Seetin, M. G., Salomon-Ferrer, R., Sagui, C., Babin, V., Luchko, T., Gusarov, S., Kovalenko, A., and Kollman, P. A. (2014) AMBER 14,University of California,San Francisco, CA, USA."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2005.12.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ct300418h"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6b00113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T16:40:50Z","timestamp":1681663250000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.6b00113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11,11]]}},"alternative-id":["10.1021\/acsinfecdis.6b00113"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6b00113","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}