{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:49:31Z","timestamp":1793328571559,"version":"4.5.0"},"reference-count":126,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["ZDSYS20230626091203007"],"award-info":[{"award-number":["ZDSYS20230626091203007"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574245"],"award-info":[{"award-number":["82574245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Medical Research Fund","award":["B2302029"],"award-info":[{"award-number":["B2302029"]}]},{"name":"Edith & Robert Zinn Chair in Drug Discovery Endowment"},{"name":"John D. Stobo, M.D. Distinguished Chair Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2026,5,8]]},"DOI":"10.1021\/acsinfecdis.6c00091","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:28:26Z","timestamp":1776828506000},"page":"1555-1571","source":"Crossref","is-referenced-by-count":2,"title":["Drug Discovery of Antiviral Inhibitors Targeting Dengue Virus NS4B Protein"],"prefix":"10.1021","volume":"12","author":[{"given":"Sikun","family":"Pang","sequence":"first","affiliation":[{"name":"School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyin","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), and Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-1090","authenticated-orcid":true,"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chemical Biology Program, Department of Pharmacology and Toxicology","place":["Galveston, United States"]},{"name":"University of Texas Medical Branch","place":["Galveston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen), and Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61687-0"},{"key":"ref2\/cit2","unstructured":"World Health\nOrganization. Dengue. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue (accessed January 16, 2026)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1110265"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0476-8"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.12.011"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00026-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6836"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1658503"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab864"},{"key":"ref11\/cit11","unstructured":"Takeda\u2019s\nQDENGA (Dengue Tetravalent Vaccine [Live, Attenuated]) Approved in\nIndonesia for Use Regardless of Prior Dengue Exposure, 2022. https:\/\/www.takeda.com\/newsroom\/newsreleases\/2022\/takedas-qdenga-dengue-tetravalent-vaccine-live-attenuated-approved-for-use-in-european-union\/ (accessed Jaunary 2, 2026)."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00522-3"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI173328"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00520-0"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1115727"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jm900652e"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.013"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01653"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.010"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00052C"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.24-0696"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00988-21"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105574"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis470"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02336"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05790-6"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2500179"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb2181"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2426922122"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.07.008"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.10.002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70730-3"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1332"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.06.002"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000785"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.03.007"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105423"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.959727"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03990-6"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50437-3"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr8338"},{"key":"ref42\/cit42","first-page":"712","volume-title":"Fields Virology","volume":"1","author":"Lindenbach B. D.","year":"2013","edition":"6"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00660-8"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.170"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2023.101305"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.12.9608-9617.1997"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005277"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.2.989-996.1993"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1504"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3108-3116.1999"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00814-06"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02704-06"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104248200"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609919200"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.9.4623-4632.2006"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02424-12"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605668103"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2335168100"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8004-8013.2005"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02188-08"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12828-12839.2005"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040017"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021840"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuu004"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.33"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600064"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00300-07"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832193100"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9683"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.10.49"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301717200"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.06.023"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1067"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153264"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153263"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.22.10787-10799.2001"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.09.015"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609919200"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512697200"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2015.09.016"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201606609"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00157-12"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007736"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.12.013"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.08.006"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00867-15"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03454-14"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81844-0"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198318"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0816-8"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.000044"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03453-14"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02782-13"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084040"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02774-12"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.3390\/v11090787"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.057"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0143-3"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.07.019"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001092"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.028"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1038\/nature18631"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.051"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.005"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0484-5"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201845889"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00913"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00403"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad284"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52819-z"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2515056"},{"key":"ref112\/cit112","unstructured":"Johnson\n& Johnson to Discontinue Phase 2 Field Study Evaluating Investigational\nAntiviral for the Prevention of Dengue. https:\/\/www.jnj.com\/media-center\/press-releases\/johnson-johnson-to-discontinue-phase-2-field-study-evaluating-investigational-antiviral-for-the-prevention-of-dengue (accessed January 3, 2026)."},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00041"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00855-15"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1021\/ml500521r"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127162"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00698"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.02.005"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05468-11"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.05.011"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02462-15"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.10.011"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1038\/nature08960"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8754"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c03159"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6c00091","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6c00091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:11:01Z","timestamp":1778227861000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.6c00091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":126,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,8]]}},"alternative-id":["10.1021\/acsinfecdis.6c00091"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6c00091","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}