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Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a prominent pathogen primarily transmitted through contaminated food, is known to trigger intestinal inflammation and subsequent infections. Temporin-GHbK (GHbK) and temporin-GHb3K (GHb3K), derived from temporin-GHb of Hylarana guentheri, were synthesized and demonstrated antimicrobial and anti-biofilm activities against EHEC in vitro. They also exhibited efficacy in preventing EHEC infection in vivo. GHbK and GHb3K significantly decreased the disease activity index (DAI) in EHEC-infected mice in comparison with the untreated model group. The derived peptides exhibited barrier-protective effects by preserving structural integrity, reducing inflammatory infiltrates in the intestinal epithelium, and maintaining gut microbiota diversity. Taken together, GHbK and GHb3K exhibit promising anti-inflammatory and anti-infection potential against EHEC infection. These findings lay a foundation for exploring the application of antibacterial peptides in the treatment of EHEC infection.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00158","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:13:15Z","timestamp":1783523595000},"page":"2663-2680","source":"Crossref","is-referenced-by-count":0,"title":["Temporin-Derived\nPeptides Protect Mice against Enterohemorrhagic\n                    <i>Escherichia coli<\/i>\n                    O157:H7 Infection by Inhibiting\nInflammation and Enhancing the Intestinal Epithelial Barrier"],"prefix":"10.1021","volume":"12","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]},{"name":"Hainan Provincial Center for Animal Disease Prevention and Control , ,","place":["Haikou, China, 571100"]},{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiju","family":"Xue","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Hu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Song","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-2368","authenticated-orcid":true,"given":"Yingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"issue":"12","key":"2026081410080246900_cit1","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.4315\/0362-028X-68.12.2623","article-title":"Emerging Infections Program FoodNet\nWorking Group. 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