{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:27:02Z","timestamp":1786721222145,"version":"build-2736575974"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["GAP-3183"],"award-info":[{"award-number":["GAP-3183"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031789","name":"Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India","doi-asserted-by":"publisher","award":["GAP3143"],"award-info":[{"award-number":["GAP3143"]}],"id":[{"id":"10.13039\/100031789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CSIR-Indian Institute Of Integrative Medicine Jammu","award":["MLP10001"],"award-info":[{"award-number":["MLP10001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is a critical threat to global public health, with emerging resistance to Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), often referred to as a silent pandemic. Despite ongoing efforts in the fight against AMR, the drug discovery pipeline remains underdeveloped, highlighting the urgent need to explore natural and synthetic approaches. Cannabinoid-inspired natural products represent an underexplored chemical space with antimicrobial potential. Herein, we report an efficient, scalable, and enantioselective synthesis and antimicrobial evaluation of epi-perrottetinene (epi-PET), an unnatural bibenzyl-based cannabinoid analog of liverwort-derived perrottetinene. The synthetic strategy employs inexpensive starting materials and a Lewis acid-mediated Friedel\u2013Crafts cyclization to enable regioselective access to both \u03948- and \u03949-epi-PET isomers. Biological evaluation revealed potent antibacterial activity against Gram-positive pathogens, with particularly strong efficacy against drug-sensitive and drug-resistant S. aureus strains, including MRSA clinical isolates. Notably, the lead compound E exhibited remarkable activity, with MIC values \u2264 1.2 \u03bcg\/mL. Compound E remained effective against efflux pump-overexpressing strains and bacterial biofilms and eradicated intracellular bacteria, while displaying low hemolytic activity (3.4% of rabbit erythrocytes) and minimal cytotoxicity toward mammalian cell lines (N2a and RAW). Mechanistic studies indicate that bacterial membrane disruption is a key contributor to the observed bactericidal activity, consistent with rapid killing and a low propensity for resistance development. The work establishes epi-perrottetinene as a promising cannabinoid-inspired antibacterial scaffold and highlights the potential of nonclassical cannabinoids as a source of new chemical matter for addressing antimicrobial resistance.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00166","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:33:53Z","timestamp":1784018033000},"page":"2681-2694","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis\nand Antibacterial Evaluation of (\u2212)-\nand (+)-\n                    <i>epi<\/i>\n                    -Perrottetinene"],"prefix":"10.1021","volume":"12","author":[{"given":"Vijay","family":"Kumar","sequence":"first","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Gangwar","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunandhani","family":"Khajuria","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Saini","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2858-0003","authenticated-orcid":true,"given":"Muzamil","family":"Samad","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-7126","authenticated-orcid":true,"given":"Rashmi","family":"Sharma","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-7945","authenticated-orcid":true,"given":"Parvinder Pal","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR - Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026081410070541600_cit1","volume-title":"Global Antibiotic Resistance\nSurveillance Report 2025","author":"Tosas Auguet","year":"2025"},{"key":"2026081410070541600_cit2","volume-title":"Antimicrobial Resistance in the EU\/EEA (EARS-Net)\n\u2013 Annual Epidemiological Report for 2024","author":"European Centre for Disease Prevention and Control.","year":"2025"},{"key":"2026081410070541600_cit3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ibneur.2024.12.011","article-title":"Exploring the diversity of cannabis\ncannabinoid and\nnon-cannabinoid compounds and their roles in Alzheimer\u2019s disease:\nA review","volume":"18","author":"Doumar","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"issue":"12","key":"2026081410070541600_cit4","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1039\/C6NP00074F","article-title":"Phytocannabinoids: a unified critical\ninventory","volume":"33","author":"Hanus\u030c","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"2026081410070541600_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116164","article-title":"Chemistry and pharmacological\naspects of furanoid cannabinoids and related compounds: Is furanoid\ncannabinoids open a new dimension towards the non-psychoactive cannabinoids?","volume":"268","author":"Anand","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"2026081410070541600_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071526","article-title":"Structure-Activity\nRelationship of Cannabis Derived Compounds for the Treatment of Neuronal\nActivity-Related Diseases","volume":"23","author":"Prandi","year":"2018","journal-title":"Molecules"},{"issue":"1","key":"2026081410070541600_cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55808-4","article-title":"Structural basis of THC analog activity\nat the Cannabinoid 1 receptor","volume":"16","author":"Gloriam","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"2026081410070541600_cit8","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0091-3057(91)90385-F","article-title":"Recent clinical\nexperience with dronabinol","volume":"40","author":"Plasse","year":"1991","journal-title":"Pharmacol., Biochem.\nBehav."},{"issue":"8","key":"2026081410070541600_cit9","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/cbdv.200790150","article-title":"Cannabis, pain,\nand sleep: lessons\nfrom therapeutic clinical trials of Sativex, a cannabis-based medicine","volume":"4","author":"Russo","year":"2007","journal-title":"Chem. Biodivers."},{"issue":"1","key":"2026081410070541600_cit10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0885-3924(97)00038-9","article-title":"Long-term\nefficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated\nanorexia","volume":"14","author":"Beal","year":"1997","journal-title":"J. Pain Symptom Manage."},{"issue":"2","key":"2026081410070541600_cit11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jpainsymman.2012.07.014","article-title":"An Open-Label Extension\nStudy to Investigate the Long-Term Safety and Tolerability of THC\/CBD\nOromucosal Spray and Oromucosal THC Spray in Patients With Terminal\nCancer-Related Pain Refractory to Strong Opioid Analgesics","volume":"46","author":"Johnson","year":"2013","journal-title":"J. Pain Symptom Manage."},{"issue":"3","key":"2026081410070541600_cit12","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/bph.12322","article-title":"Evaluation\nof the potential of the phytocannabinoids, cannabidivarin (CBDV) and\n\u03949-tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse\nagonism symptoms of nausea in rats","volume":"170","author":"Rock","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"2026081410070541600_cit13","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv092","article-title":"The CB1 Neutral\nAntagonist Tetrahydrocannabivarin\nReduces Default Mode Network and Increases Executive Control Network\nResting State Functional Connectivity in Healthy Volunteers","volume":"19","author":"Rzepa","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"2026081410070541600_cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47812-2","article-title":"Complex\nPatterns of Cannabinoid Alkyl Side-Chain Inheritance in Cannabis","volume":"9","author":"Welling","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"2026081410070541600_cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s42238-019-0008-7","article-title":"Distribution of cannabinoid synthase\ngenes in non-Cannabis organisms","volume":"1","author":"Aryal","year":"2019","journal-title":"J. Cannabis\nRes."},{"issue":"05","key":"2026081410070541600_cit16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1055\/s-0042-1751539","article-title":"Synthesis\nof Stilbenyl and Bibenzyl Cannabinoids and Analysis of Their Cannabimimetic\nPotential","volume":"56","author":"Jordan","year":"2024","journal-title":"Synthesis"},{"issue":"10","key":"2026081410070541600_cit17","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat2166","article-title":"Uncovering the psychoactivity of\na cannabinoid from liverworts associated with a legal high","volume":"4","author":"Chicca","year":"2018","journal-title":"Sci. Adv."},{"issue":"10","key":"2026081410070541600_cit18","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1021\/acs.jnatprod.5c00826","article-title":"Cannabizetol, a Novel\nCannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction\nfrom Cannabis sativa L","volume":"88","author":"Pozzi","year":"2025","journal-title":"J. Nat. Prod."},{"key":"2026081410070541600_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2025.105411","article-title":"Proteomic\nand metabolomic analyses\nreveal the antibacterial mechanism of Cannabidiol against gram-positive\nbacteria","volume":"315","author":"Zeng","year":"2025","journal-title":"J. Pharmacol. Sci."},{"issue":"5","key":"2026081410070541600_cit20","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1039\/p19880001263","article-title":"Synthesis\nof bibenzyl cannabinoids,\nhybrids of two biogenetic series found in Cannabis sativa","author":"Crombie","year":"1988","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"issue":"14","key":"2026081410070541600_cit21","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1039\/C4CC08562K","article-title":"Protecting\ngroup free enantiospecific total syntheses of structurally diverse\nnatural products of the tetrahydrocannabinoid family","volume":"51","author":"Dethe","year":"2015","journal-title":"Chem. Commun."},{"issue":"37","key":"2026081410070541600_cit22","doi-asserted-by":"publisher","first-page":"12761","DOI":"10.1002\/anie.201900932","article-title":"IDPi Catalysis","volume":"58","author":"Schreyer","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"40","key":"2026081410070541600_cit23","doi-asserted-by":"publisher","first-page":"7961","DOI":"10.1016\/j.tet.2003.08.009","article-title":"Regioselective\nreductive demethoxylation of 3,4,5-trimethoxystilbenes","volume":"59","author":"Azzena","year":"2003","journal-title":"Tetrahedron"},{"issue":"7","key":"2026081410070541600_cit24","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1021\/acs.joc.1c02571","article-title":"Stereoselective\nSynthesis of Nonpsychotic Natural Cannabidiol and Its Unnatural\/Terpenyl\/Tail-Modified\nAnalogues","volume":"87","author":"Anand","year":"2022","journal-title":"J. Org. Chem."},{"issue":"43","key":"2026081410070541600_cit25","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1016\/S0040-4039(01)89133-4","article-title":"Conformational effects\nin the opening of cis\/trans\n1, 4-dialkyl substituted 1, 2-cyclohexene epoxides with acetic acid","volume":"6","author":"Leffingwell","year":"1965","journal-title":"Tetrahedron Lett."},{"key":"2026081410070541600_cit26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1590\/S0074-02762008000800005","article-title":"Synthesis\nof limonene \u03b2-amino alcohol derivatives in support of new antileishmanial\ntherapies","volume":"103","author":"Ferrarini","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz."},{"issue":"34","key":"2026081410070541600_cit27","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1016\/S0040-4039(01)01135-2","article-title":"A simple and convenient synthesis\nof \u03b2-amino\nalcohol chiral auxiliaries based on limonene oxide","volume":"42","author":"Chrisman","year":"2001","journal-title":"Tetrahedron Lett."},{"issue":"7","key":"2026081410070541600_cit28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287973","article-title":"Genomic\nalterations involved in fluoroquinolone\nresistance development in Staphylococcus aureus","volume":"18","author":"Huynh","year":"2023","journal-title":"PLoS One"},{"issue":"7","key":"2026081410070541600_cit29","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13070623","article-title":"Medical device-associated infections\ncaused by biofilm-forming microbial pathogens and controlling strategies","volume":"13","author":"Mishra","year":"2024","journal-title":"Antibiotics"},{"key":"2026081410070541600_cit30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.15585\/mmwr.mm6809e1","article-title":"Vital signs: epidemiology\nand recent\ntrends in methicillin-resistant and in methicillin-susceptible Staphylococcus\naureus bloodstream infections\u2500United States","volume":"68","author":"Kourtis","year":"2019","journal-title":"Morb. Mortal. Wkly. Rep."},{"issue":"15","key":"2026081410070541600_cit31","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1002\/cbic.201402254","article-title":"Biofilm-eradicating\nproperties of quaternary ammonium amphiphiles: simple mimics of antimicrobial\npeptides","volume":"15","author":"Jennings","year":"2014","journal-title":"ChemMedChem"},{"issue":"18","key":"2026081410070541600_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38127","article-title":"In-vitro\nNeuro-2a cytotoxicity analysis and molecular\ndocking investigation on potential anti-amyloid agents from Adiantum\nlunulatum","volume":"10","author":"Jerom","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"2026081410070541600_cit33","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02487-19","article-title":"A roadblock-and-kill\nmechanism of action model for\nthe DNA-targeting antibiotic ciprofloxacin","volume":"64","author":"Ojkic","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"2026081410070541600_cit34","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025320","article-title":"Topoisomerase inhibitors: fluoroquinolone mechanisms\nof action and resistance","volume":"6","author":"Hooper","year":"2016","journal-title":"Cold Spring Harb.\nPerspect. Med."},{"key":"2026081410070541600_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104915","article-title":"Emerging\nresistance mechanisms for 4 types of common\nanti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review","volume":"156","author":"Liu","year":"2021","journal-title":"Microb. Pathog."},{"issue":"15","key":"2026081410070541600_cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158088","article-title":"Molecular mechanisms\nof drug resistance in Staphylococcus aureus","volume":"23","author":"Mlynarczyk-Bonikowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026081410070541600_cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60952-0","article-title":"Cannabidiol is an effective helper\ncompound in combination with bacitracin to kill Gram-positive bacteria","volume":"10","author":"Wassmann","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"2026081410070541600_cit38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1021\/acsinfecdis.9b00419","article-title":"Uncovering\nthe hidden antibiotic potential of cannabis","volume":"6","author":"Farha","year":"2020","journal-title":"ACS Infect. Dis."},{"issue":"1","key":"2026081410070541600_cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00320-0","article-title":"In silico identification\nof two peptides with\nantibacterial activity against multidrug-resistant Staphylococcus\naureus","volume":"8","author":"Oyama","year":"2022","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"17","key":"2026081410070541600_cit40","doi-asserted-by":"publisher","first-page":"12903","DOI":"10.1021\/acs.jmedchem.1c01073","article-title":"Development of membrane-active honokiol\/magnolol\namphiphiles as potent antibacterial agents against methicillin-resistant\nStaphylococcus aureus (MRSA)","volume":"64","author":"Guo","year":"2021","journal-title":"J. Med. Chem."},{"issue":"5","key":"2026081410070541600_cit41","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1128\/AAC.01602-10","article-title":"Multistep\nresistance development studies of ceftaroline in gram-positive and-negative\nbacteria","volume":"55","author":"Clark","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"2026081410070541600_cit42","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxaf214","article-title":"The\nanti-biofilm activity of cannabinoids against methicillin-resistant\nStaphylococcus aureus","volume":"136","author":"Kwong","year":"2025","journal-title":"J. Appl. Microbiol."},{"issue":"11","key":"2026081410070541600_cit43","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13111023","article-title":"Cannabinoids as antibacterial\nagents:\na systematic and critical review of in vitro efficacy against Streptococcus\nand Staphylococcus","volume":"13","author":"Niyangoda","year":"2024","journal-title":"Antibiotics"},{"issue":"17","key":"2026081410070541600_cit44","doi-asserted-by":"publisher","first-page":"7877","DOI":"10.1021\/acs.jmedchem.6b00640","article-title":"Small\nantimicrobial agents based on acylated reduced amide scaffold","volume":"59","author":"Teng","year":"2016","journal-title":"J. Med. Chem."},{"issue":"38","key":"2026081410070541600_cit45","doi-asserted-by":"publisher","first-page":"35321","DOI":"10.1021\/acsomega.3c05156","article-title":"Boron clusters alter\nthe membrane\npermeability of dicationic fluorescent DNA-staining dyes","volume":"8","author":"Hirai","year":"2023","journal-title":"Anal. Chem."},{"key":"2026081410070541600_cit46","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2147\/IDR.S146748","article-title":"Correlation between resistance mechanisms in Staphylococcus\naureus and cell wall and septum thickening","volume":"10","author":"Garci\u0301a","year":"2017","journal-title":"Infect. Drug Resist."},{"issue":"11","key":"2026081410070541600_cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000660","article-title":"The bacterial\ndefensin resistance protein MprF consists of separable domains for\nlipid lysinylation and antimicrobial peptide repulsion","volume":"5","author":"Ernst","year":"2009","journal-title":"PLoS Pathog."},{"issue":"11","key":"2026081410070541600_cit48","doi-asserted-by":"publisher","first-page":"9302","DOI":"10.1021\/acs.jmedchem.4c00436","article-title":"Development of membrane-targeting\nfluorescent 2-phenyl-1 h-phenanthro [9, 10-d] imidazole-antimicrobial\npeptide mimic conjugates against methicillin-resistant Staphylococcus\naureus","volume":"67","author":"Xu","year":"2024","journal-title":"J. Med. Chem."},{"issue":"24","key":"2026081410070541600_cit49","doi-asserted-by":"publisher","first-page":"16879","DOI":"10.1021\/acs.jmedchem.2c01674","article-title":"Membrane-targeting neolignan-antimicrobial\npeptide mimic conjugates to combat methicillin-resistant Staphylococcus\naureus (MRSA) infections","volume":"65","author":"Yang","year":"2022","journal-title":"J. Med. Chem."},{"key":"2026081410070541600_cit50","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.540898","article-title":"A how-to guide for mode of action analysis of antimicrobial\npeptides","volume":"10","author":"Scha\u0308fer","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"2026081410070541600_cit51","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03275-23","article-title":"Dissecting antibiotic\neffects on the cell envelope\nusing bacterial cytological profiling: a phenotypic analysis starter\nkit","volume":"12","author":"Scha\u0308fer","year":"2024","journal-title":"Microbiol. Spectr."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6c00166","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2681\/65901217\/acsinfecdis.6c00166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2681\/65901217\/acsinfecdis.6c00166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:28:21Z","timestamp":1786717701000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/12\/8\/2681\/5207812\/Total-Synthesis-and-Antibacterial-Evaluation-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6c00166","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]}}}