{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:28:28Z","timestamp":1786721308071,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/14310-3"],"award-info":[{"award-number":["2023\/14310-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/15407-0"],"award-info":[{"award-number":["2023\/15407-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/17308-0"],"award-info":[{"award-number":["2023\/17308-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to South America caused by thermodimorphic fungi of the genus Paracoccidioides, particularly P. brasiliensis. Calcineurin inhibition by cyclosporine A (CsA) perturbs fungal thermodimorphism and growth. Here, we asked whether pre-exposure of P. brasiliensis yeasts to CsA modulates host\u2013pathogen interactions during infection. Mice infected with CsA-pre-exposed fungi exhibited significantly reduced levels of pro- and anti-inflammatory cytokines, along with decreased recruitment and activation of innate and adaptive immune cells at both time points. Although tissue inflammation and lesion areas were diminished, fungal burdens in lungs and liver were similar between groups. Importantly, yeasts recovered from lungs 72 h after infection with CsA-pretreated fungi displayed reduced in vitro colony growth, suggesting that prior CsA exposure induces a persistent slow-growth physiological state. This altered phenotype may impair effective immune recognition and inflammatory activation. As host immunosuppression was excluded in the experimental design, fungus-intrinsic phenotypes consistent with transient calcineurin pathway inhibition: altered growth\/morphogenesis and putatively modified PAMP exposure that together blunt early immune activation. We interpret late-phase differences as downstream of these early pathway-dependent shifts rather than as heritable reprogramming. Overall, pre-exposure to CsA modulates P. brasiliensis\u2013host interaction, dissociating tissue injury from fungal burden, highlights the role of calcineurin in fungal adaptation, and demonstrates how environmental exposure to bioactive compounds can influence fungal virulence and disease outcomes.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00285","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:34:44Z","timestamp":1785854084000},"page":"2727-2738","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Exposure\nto Cyclosporine A Primes\n                    <i>Paracoccidioides brasiliensis<\/i>\n                    to Evade Host Immunity"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-0607","authenticated-orcid":true,"given":"Filipe Nogueira","family":"Franco","sequence":"first","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean de Souza Lisboa","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nycolas Willian","family":"Preite","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Molist-Homs","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Furtado","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joa\u0303o Henrique Dal Ponte","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u0301rica Borges","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-4063","authenticated-orcid":true,"given":"Fla\u0301vio Vieira","family":"Loures","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-0915","authenticated-orcid":true,"given":"Claudia Barbosa Ladeira de","family":"Campos","sequence":"additional","affiliation":[{"name":"Federal University of Sa\u0303o Paulo , , Rua Talim, 330 - Vila Nair , , ,","place":["Sa\u0303o Jose\u0301 dos Campos, Sa\u0303o Paulo, Brazil, CEP 12231-280"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026081410074688100_cit1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1021\/acsbiomedchemau.2c00055","article-title":"Antifungal\ndevelopment and the urgency of minimizing the impact of fungal diseases\non public health","volume":"3","author":"de Oliveira","year":"2023","journal-title":"ACS Bio Med. Chem. Au"},{"key":"2026081410074688100_cit2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00233-21","article-title":"Paracoccidioidomycosis: current status\nand future trends","volume":"35","author":"Hahn","year":"2022","journal-title":"Clin. Microbiol. Rev."},{"issue":"3","key":"2026081410074688100_cit3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/13693786.2012.714529","article-title":"Endemic Paracoccidioidomycosis:\nRelationship between Clinical Presentation and Patients\u2019 Demographic\nFeatures","volume":"51","author":"Bellissimo-Rodrigues","year":"2013","journal-title":"Med. Mycol."},{"issue":"5","key":"2026081410074688100_cit4","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jinf.2013.07.019","article-title":"Characterization of the Immune Response in Human Paracoccidioidomycosis","volume":"67","author":"de Castro","year":"2013","journal-title":"J. Infect."},{"key":"2026081410074688100_cit5","doi-asserted-by":"publisher","first-page":"053","DOI":"10.1055\/s-0039-3400544","article-title":"New insights\non pulmonary paracoccidioidomycosis","volume":"41","author":"Queiroz-Telles","year":"2020","journal-title":"Semin.\nRespir. Crit. Care Med."},{"key":"2026081410074688100_cit6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian\nguidelines\nfor the clinical management of paracoccidioidomycosis","volume":"50","author":"Shikanai-Yasuda","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"2026081410074688100_cit7","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1021\/acsinfecdis.5c00944","article-title":"Synergistic effect\nof 5-fluorouracil and amphotericin B in murine paracoccidioidomycosis:\nimmune modulation and enhanced fungal clearance","volume":"12","author":"Franco","year":"2026","journal-title":"ACS Infect. Dis."},{"key":"2026081410074688100_cit8","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1128\/AAC.47.8.2404-2412.2003","article-title":"Candida albicans\nmutations in the ergosterol biosynthetic pathway and resistance to\nseveral antifungal agents","volume":"47","author":"Sanglard","year":"2003","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081410074688100_cit9","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1128\/EC.00110-08","article-title":"Evidence\nfor the role of calcineurin in morphogenesis and calcium homeostasis\nduring mycelium-to-yeast dimorphism of Paracoccidioides brasiliensis","volume":"7","author":"Campos","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"2026081410074688100_cit10","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1128\/EC.2.3.422-430.2003","article-title":"Calcineurin is essential for Candida\nalbicans survival in serum and virulence","volume":"2","author":"Blankenship","year":"2003","journal-title":"Eukaryot.\nCell"},{"key":"2026081410074688100_cit11","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1128\/IAI.71.9.5344-5354.2003","article-title":"Calcineurin\nis essential for virulence in Candida albicans","volume":"71","author":"Bader","year":"2003","journal-title":"Infect. Immun."},{"key":"2026081410074688100_cit12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.transproceed.2004.01.021","article-title":"Protective effect of\nedaravone against cyclosporine-induced chronic nephropathy through\nantioxidant and nitric oxide modulating pathways in rats","volume":"42","author":"Sattarinezhad","year":"2017","journal-title":"Iran J. Med. Sci."},{"key":"2026081410074688100_cit13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1128\/AAC.44.1.143-149.2000","article-title":"Immunosuppressive\nand nonimmunosuppressive cyclosporine\nanalogs are toxic to the opportunistic fungal pathogen Cryptococcus\nneoformans via cyclophilin-dependent inhibition of calcineurin","volume":"44","author":"Cruz","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026081410074688100_cit14","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/B978-0-12-818731-9.00068-9","article-title":"Immunosuppressive drugs","volume-title":"Encyclopedia Of Infection\nAnd Immunity","author":"Hussain","year":"2022"},{"key":"2026081410074688100_cit15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1164\/ajrccm\/139.1.8","article-title":"Treatment\nof murine cryptococcosis\nwith cyclosporin-A in normal and athymic mice","volume":"139","author":"Mody","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026081410074688100_cit16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1023\/A:1006827828838","article-title":"Influences of immunosuppressive agents, FK506 and cyclosporin\non systemic Candida albicans infection in mice","volume":"138","author":"Ito","year":"1997","journal-title":"Mycopathologia"},{"key":"2026081410074688100_cit17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1099\/00222615-30-3-183","article-title":"Immunosuppressive effect of cyclosporin A on resistance\nto systemic infection with Candida albicans","volume":"30","author":"Vecchiarelli","year":"1989","journal-title":"J. Med. Microbiol."},{"key":"2026081410074688100_cit18","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1039\/C5NP00013K","article-title":"Natural products in soil microbe\ninteractions and evolution","volume":"32","author":"Traxler","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"2026081410074688100_cit19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF00928431","article-title":"Cyclosporin\nA and C","volume":"3","author":"Dreyfuss","year":"1976","journal-title":"Eur. J.\nAppl. Microbiol."},{"key":"2026081410074688100_cit20","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.7164\/antibiotics.40.1249","article-title":"FK-506, a novel immunosuppressant isolated from a Streptomyces","volume":"40","author":"Kino","year":"1987","journal-title":"J. Antibiot."},{"key":"2026081410074688100_cit21","first-page":"191","article-title":"Natural product diversity from multiple\nspecies of\nfungi and actinomycetes: cyclosporins, tacrolimus, and related secondary\nmetabolites","volume":"42","author":"Rateb","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"2026081410074688100_cit22","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin\nis a common target of cyclophilin-cyclosporin\nA and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"2026081410074688100_cit23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/embo-reports\/kve109","article-title":"Two cyclophilin\nA homologs with shared and distinct functions important for growth\nand virulence of Cryptococcus neoformans","volume":"2","author":"Wang","year":"2001","journal-title":"EMBO\nRep."},{"key":"2026081410074688100_cit24","doi-asserted-by":"publisher","first-page":"13093","DOI":"10.1073\/pnas.94.24.13093","article-title":"All cyclophilins and\nFK506 binding proteins are, individually and collectively, dispensable\nfor viability in Saccharomyces cerevisiae","volume":"94","author":"Dolinski","year":"1997","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."},{"key":"2026081410074688100_cit25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1471-2180-7-92","article-title":"Ecological\nStudy of Paracoccidioides brasiliensis in Soil: Growth\nAbility, Conidia Production and Molecular Detection","volume":"7","author":"Terc\u0327arioli","year":"2007","journal-title":"BMC Microbiol."},{"key":"2026081410074688100_cit26","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760200208","article-title":"Paracoccidioides brasiliensis Habitat: Far beyond Armadillo Burrows?","volume":"115","author":"de Macedo","year":"2020","journal-title":"Mem.\nInst. Oswaldo Cruz."},{"key":"2026081410074688100_cit27","doi-asserted-by":"publisher","first-page":"S229","DOI":"10.1016\/j.transproceed.2004.01.021","article-title":"Cyclosporine nephrotoxicity","volume":"36","author":"Busauschina","year":"2004","journal-title":"Transplant. Proceed."},{"key":"2026081410074688100_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1610","article-title":"A One Health approach to overcoming\nfungal disease and antifungal resistance","volume":"15","author":"Woods","year":"2023","journal-title":"WIREs\nMech. Dis."},{"issue":"2","key":"2026081410074688100_cit29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2215\/CJN.04800908","article-title":"Calcineurin\nInhibitor Nephrotoxicity","volume":"4","author":"Naesens","year":"2009","journal-title":"Clin J. Am. Soc. Nephrol."},{"key":"2026081410074688100_cit30","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/bies.10157","article-title":"Good fungi\ngone bad: the corruption of calcineurin","volume":"24","author":"Fox","year":"2002","journal-title":"Bioessays"},{"issue":"6","key":"2026081410074688100_cit31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/nrmicro1680","article-title":"Harnessing\nCalcineurin as a Novel Anti-Infective Agent against Invasive Fungal\nInfections","volume":"5","author":"Steinbach","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"2026081410074688100_cit32","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1128\/AAC.47.3.956-964.2003","article-title":"Ergosterol biosynthesis\ninhibitors become fungicidal when combined with calcineurin inhibitors\nagainst Candida albicans, Candida glabrata, and Candida krusei","volume":"47","author":"Onyewu","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"2026081410074688100_cit33","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1128\/MCB.15.8.4103","article-title":"the\nCa2+Calmodulin-Dependent\nProtein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity\nDefects and in Mutants That Lack a Functional Vacuolar HATPase","volume":"15","author":"Garrett-Engele","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"2026081410074688100_cit34","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fmicb.2015.00913","article-title":"Expression of\nDectin-1 and Enhanced\nActivation of NALP3 Inflammasome Are Associated with Resistance to\nParacoccidioidomycosis","volume":"6","author":"Feriotti","year":"2015","journal-title":"Front. Microbiol."},{"key":"2026081410074688100_cit35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.fbr.2014.02.004","article-title":"Calcineurin\nas a multifunctional\nregulator: unraveling novel functions in fungal stress responses,\nhyphal growth, drug resistance, and pathogenesis","volume":"28","author":"Juvvadi","year":"2014","journal-title":"Fungal Biol. Rev."},{"key":"2026081410074688100_cit36","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1086\/318146","article-title":"Paracoccidioidomycosis: a model for\nevaluation of the\neffects of human immunodeficiency virus infection on the natural history\nof endemic tropical diseases","volume":"31","author":"Benard","year":"2000","journal-title":"Clin. Infect.\nDis."},{"issue":"9\u201310","key":"2026081410074688100_cit37","first-page":"6","article-title":"Complex\nof cyclosporins produced by Tolypocladium inflatum isolated from soil sample from Buriatiia","volume":"54","author":"Bibikova","year":"2009","journal-title":"Antibiot. Khimioter."},{"issue":"6","key":"2026081410074688100_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00039-9","article-title":"Impact\nof Climate Change and Natural Disasters on Fungal\nInfections","volume":"5","author":"Seidel","year":"2024","journal-title":"Lancet Microbe"},{"issue":"3","key":"2026081410074688100_cit39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000643","article-title":"First Description\nof a Cluster of Acute\/Subacute Paracoccidioidomycosis\nCases and Its Association with a Climatic Anomaly","volume":"4","author":"Barrozo","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"10","key":"2026081410074688100_cit40","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3390\/toxins14100721","article-title":"Cyclosporin\nA as a Source for a Novel Insecticidal Product for Controlling Spodoptera frugiperda","volume":"14","author":"Sun","year":"2022","journal-title":"Toxins"},{"issue":"3","key":"2026081410074688100_cit41","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jip.2008.03.015","article-title":"Immunosuppressive\nEffect of Cyclosporin A on Insect Humoral Immune Response","volume":"98","author":"Fiolka","year":"2008","journal-title":"J. Invertebr. Pathol."},{"issue":"8","key":"2026081410074688100_cit42","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1080\/21505594.2017.1339007","article-title":"Treatment with Cyclosporin A Retains\nHost Defense against Invasive Pulmonary Aspergillosis in a Non-Immunosuppressive\nMurine Model by Preserving the Myeloid Cell Population","volume":"8","author":"Wong","year":"2017","journal-title":"Virulence"},{"key":"2026081410074688100_cit43","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1093\/infdis\/jiae350","article-title":"Specific depletion\nof myeloid-derived\nsuppressor cells by the chemotherapy agent 5-fluorouracil enhances\nprotective immune response in paracoccidioidomycosis","volume":"230","author":"Preite","year":"2024","journal-title":"J. Infect. Dis."},{"key":"2026081410074688100_cit44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1365-2249.1993.tb05980.x","article-title":"Experimental murine\nparacoccidioidomycosis: relationship among the dissemination of the\ninfection, humoral and cellular immune responses","volume":"94","author":"Singer-Vermes","year":"2008","journal-title":"Clin. Exp. Immunol."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6c00285","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2727\/66357809\/acsinfecdis.6c00285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2727\/66357809\/acsinfecdis.6c00285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:32:51Z","timestamp":1786717971000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/12\/8\/2727\/5238540\/Pre-Exposure-to-Cyclosporine-A-Primes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,3]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6c00285","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]}}}