{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:01:54Z","timestamp":1786719714291,"version":"build-2736575974"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["OFIRG24jan-0064"],"award-info":[{"award-number":["OFIRG24jan-0064"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["RT0120"],"award-info":[{"award-number":["RT0120"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Singapore Therapeutics Development Review","award":["H22G0a0003"],"award-info":[{"award-number":["H22G0a0003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mycobacterium abscessus is an intrinsically drug-resistant pathogen responsible for chronic lung infections that are notoriously difficult to cure. Its complex, multilayered cell wall limits drug penetration and underlies the poor efficacy of most antibiotics. Here, we show that targeting multiple components of cell wall biosynthesis simultaneously can convert otherwise inactive agents into potent, bactericidal combinations. Pairing glycopeptides with \u03b2-lactams led to synergistic killing, while inclusion of ethambutol further enhances potency. Mechanistic studies indicated that the combinations act through cumulative weakening of the cell envelope. Concomitant inhibition of peptidoglycan and arabinogalactan or lipoarabinomannan synthesis caused extensive ATP leakage and improved access of vancomycin to its targets, consistent with additive structural damage. This multilayered disruption rendered the cell wall unable to maintain integrity. The triple combination of teicoplanin, cefoxitin and ethambutol also decreased lung bacterial loads in mice infected with M. abscessus. These findings establish that intrinsic antibiotic resistance in M. abscessus can be overcome by coordinated interference with cell wall biogenesis using clinically available antibiotics. This strategy provides a mechanistic framework for rational repurposing of existing drugs to treat nontuberculous mycobacterial infections for which new therapies are urgently needed.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00309","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:38:00Z","timestamp":1784677080000},"page":"2750-2762","source":"Crossref","is-referenced-by-count":0,"title":["Multipronged\nCell Wall-Targeting Converts Ineffective\nAntibiotics into a Potent Regimen against\n                    <i>Mycobacterium abscessus<\/i>"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-1660","authenticated-orcid":true,"given":"Carmen J. E.","family":"Pee","sequence":"first","affiliation":[{"name":"Nanyang Technological University , , ,","place":["Singapore, Singapore, 636921"]},{"name":"Nanyang Technological University , , ,","place":["Singapore, Singapore, 637335"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Delos","family":"Santos","sequence":"additional","affiliation":[{"name":"Singapore-MIT Alliance for Research and Technology , , 1 CREATE Way , ,","place":["Singapore, Singapore, 138602"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pethe","sequence":"additional","affiliation":[{"name":"Nanyang Technological University , , ,","place":["Singapore, Singapore, 636921"]},{"name":"Singapore-MIT Alliance for Research and Technology , , 1 CREATE Way , ,","place":["Singapore, Singapore, 138602"]},{"name":"Nanyang Technological University , , ,","place":["Singapore, Singapore, 637551"]},{"name":"University of Oxford , , ,","place":["Oxford, United Kingdom, OX1 3EL"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"8","key":"2026081410073338100_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082541","article-title":"General Overview\nof Nontuberculous Mycobacteria Opportunistic Pathogens: Mycobacterium Avium and Mycobacterium Abscessus","volume":"9","author":"To","year":"2020","journal-title":"J. Clin. Med."},{"key":"2026081410073338100_cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00303","article-title":"The Rise\nof Non-Tuberculosis Mycobacterial Lung Disease","volume":"11","author":"Ratnatunga","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"2026081410073338100_cit3","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3201\/eid2206.151642","article-title":"Prevalence\nof Nontuberculous Mycobacterial Pulmonary Disease, Germany, 2009\u20132014","volume":"22","author":"Ringshausen","year":"2016","journal-title":"Emerg. Infect. Dis."},{"issue":"6","key":"2026081410073338100_cit4","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.3201\/eid2206.151086","article-title":"Epidemiology of Pulmonary Nontuberculous Mycobacterial\nDisease, Japan","volume":"22","author":"Namkoong","year":"2016","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"2026081410073338100_cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0637-1","article-title":"Profiling\nNon-Tuberculous Mycobacteria\nin an Asian Setting: Characteristics and Clinical Outcomes of Hospitalized\nPatients in Singapore","volume":"18","author":"Lim","year":"2018","journal-title":"BMC Pulm. Med."},{"issue":"11","key":"2026081410073338100_cit6","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1099\/ijsem.0.001376","article-title":"Emended Description\nof Mycobacterium Abscessus, Mycobacterium Abscessus Subsp. Abscessus\nand Mycobacteriumabscessus Subsp. Bolletii and Designation of Mycobacteriumabscessus\nSubsp. Massiliense Comb. Nov","volume":"66","author":"Tortoli","year":"2016","journal-title":"Int. J. Syst.\nEvol. Microbiol."},{"issue":"1","key":"2026081410073338100_cit7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1099\/ijsem.0.002457","article-title":"Mycobacterium\nAbscessus, a Taxonomic Puzzle","volume":"68","author":"Tortoli","year":"2018","journal-title":"Int. J. Syst.\nEvol. Microbiol."},{"issue":"4","key":"2026081410073338100_cit8","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/jac\/dkr578","article-title":"Mycobacterium\nAbscessus: A New Antibiotic Nightmare","volume":"67","author":"Nessar","year":"2012","journal-title":"J. Antimicrob.\nChemother."},{"issue":"4","key":"2026081410073338100_cit9","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciaa241","article-title":"Treatment of Nontuberculous\nMycobacterial Pulmonary Disease: An Official ATS\/ERS\/ESCMID\/IDSA Clinical\nPractice Guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"2026081410073338100_cit10","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/DDDT.S146111","article-title":"The Use of Amikacin Liposome Inhalation Suspension\n(Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial\nLung Disease in Adults","volume":"14","author":"Khan","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"2026081410073338100_cit11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3201\/eid2203.150828","article-title":"Treatment\nof Mycobacterium Abscessus Infection","volume":"22","author":"Novosad","year":"2016","journal-title":"Emerg.\nInfect. Dis."},{"issue":"9","key":"2026081410073338100_cit12","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1164\/rccm.200905-0704OC","article-title":"Antibiotic\nTreatment of Mycobacterium Abscessus Lung Disease","volume":"180","author":"Jeon","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"2026081410073338100_cit13","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00060-2022","article-title":"Nontuberculous\nMycobacteria Infection and Pulmonary\nDisease in Bronchiectasis","volume":"8","author":"Suska","year":"2022","journal-title":"ERJ Open Res."},{"key":"2026081410073338100_cit14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mib.2021.01.012","article-title":"Synthesis and Recycling of the Mycobacterial Cell Envelope","volume":"60","author":"Abrahams","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"key":"2026081410073338100_cit15","doi-asserted-by":"crossref","unstructured":"Daffe\u0301, M.; Marrakchi, H.\n          Unraveling\nthe Structure of the Mycobacterial Envelope\n          Microbiol. 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Chemother."},{"issue":"1\u20132","key":"2026081410073338100_cit18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1574-6968.1994.tb07194.x","article-title":"Mycobacterial Cell\nWall: Structure and Role in Natural\nResistance to Antibiotics","volume":"123","author":"Jarlier","year":"1994","journal-title":"FEMS Microbiol. Lett."},{"issue":"10","key":"2026081410073338100_cit19","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1099\/00221287-148-10-3089","article-title":"The Impact\nof the Absence of Glycopeptidolipids\non the Ultrastructure, Cell Surface and Cell Wall Properties, and\nPhagocytosis of Mycobacterium smegmatis","volume":"148","author":"Etienne","year":"2002","journal-title":"Microbiology"},{"issue":"3","key":"2026081410073338100_cit20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/cid\/ciw724","article-title":"Mycobacterial\nCharacteristics and Treatment Outcomes in Mycobacterium Abscessus\nLung Disease","volume":"64","author":"Koh","year":"2017","journal-title":"Clin. Infect. Dis."},{"issue":"6","key":"2026081410073338100_cit21","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1093\/infdis\/jiad007","article-title":"A Rough Colony\nMorphology of Mycobacterium Abscessus Is Associated With Cavitary\nPulmonary Disease and Poor Clinical Outcome","volume":"227","author":"Hedin","year":"2023","journal-title":"J. Infect. Dis."},{"issue":"1","key":"2026081410073338100_cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244200","article-title":"Real-Time Monitoring\nof Extracellular ATP in Bacterial Cultures Using Thermostable Luciferase","volume":"16","author":"Ihssen","year":"2021","journal-title":"PLoS One"},{"issue":"6","key":"2026081410073338100_cit23","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1074\/jbc.RA118.005732","article-title":"Inhibitors\nof Energy Metabolism Interfere\nwith Antibiotic-Induced Death in Mycobacteria","volume":"294","author":"Lee","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"8","key":"2026081410073338100_cit24","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00827-19","article-title":"Bedaquiline Eliminates\nBactericidal Activity of \u03b2-Lactams against\nMycobacterium Abscessus","volume":"63","author":"Lindman","year":"2019","journal-title":"Antimicrob. Agents\nChemother."},{"issue":"5","key":"2026081410073338100_cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2026.117311","article-title":"A Bioluminescence-Based\nChemical Screen Identifies a Bactericidal Naphthalen-1-Ylmethanamine\nScaffold Targeting MmpL3 in Mycobacterium Abscessus","volume":"45","author":"Singh","year":"2026","journal-title":"Cell Rep."},{"issue":"10","key":"2026081410073338100_cit26","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1128\/AAC.41.10.2270","article-title":"Role of embB in Natural\nand Acquired\nResistance to Ethambutol in Mycobacteria","volume":"41","author":"Alcaide","year":"1997","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"6496","key":"2026081410073338100_cit27","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1126\/science.aba9102","article-title":"Structures\nof Cell Wall Arabinosyltransferases with the Anti-Tuberculosis Drug\nEthambutol","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"issue":"51","key":"2026081410073338100_cit28","doi-asserted-by":"publisher","first-page":"35172","DOI":"10.1074\/jbc.M114.583112","article-title":"Mutations in the Essential\nArabinosyltransferase EmbC Lead to Alterations in Mycobacterium Tuberculosis\nLipoarabinomannan","volume":"289","author":"Korkegian","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"10","key":"2026081410073338100_cit29","doi-asserted-by":"publisher","first-page":"4138","DOI":"10.1128\/AAC.00162-09","article-title":"The Arabinosyltransferase\nEmbC Is Inhibited by Ethambutol in Mycobacterium Tuberculosis","volume":"53","author":"Goude","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"2026081410073338100_cit30","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nm0597-567","article-title":"The Emb\nOperon, a Gene Cluster of Mycobacterium Tuberculosis Involved in Resistance\nto Ethambutol","volume":"3","author":"Telenti","year":"1997","journal-title":"Nat. Med."},{"issue":"21","key":"2026081410073338100_cit31","doi-asserted-by":"publisher","first-page":"11919","DOI":"10.1073\/pnas.93.21.11919","article-title":"The embAB\nGenes\nof Mycobacterium Avium Encode an Arabinosyl\nTransferase Involved in Cell Wall Arabinan Biosynthesis That Is the\nTarget for the Antimycobacterial Drug Ethambutol","volume":"93","author":"Belanger","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"735","key":"2026081410073338100_cit32","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi7558","article-title":"An Anti-Mycobacterial Conjugated\nOligoelectrolyte Effective against Mycobacterium Abscessus","volume":"16","author":"Zhang","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"2026081410073338100_cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60452-1","article-title":"A Mouse Model\nof Pulmonary Mycobacteroides Abscessus\nInfection","volume":"10","author":"Maggioncalda","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"2026081410073338100_cit34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1128\/AAC.33.1.82","article-title":"Pharmacokinetics\nof Single- and Multiple-Dose Teicoplanin\nin Healthy Volunteers","volume":"33","author":"Carver","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"2026081410073338100_cit35","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000238568","article-title":"Pharmacokinetics of\nTeicoplanin","volume":"34","author":"Ripa","year":"1988","journal-title":"Chemotherapy"},{"key":"2026081410073338100_cit36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/jac\/21.suppl_A.39","article-title":"Pharmacokinetics of Teicoplanin in\nthe Elderly","volume":"21","author":"Rosina","year":"1988","journal-title":"J. Antimicrob. Chemother."},{"issue":"8","key":"2026081410073338100_cit37","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1128\/AAC.32.8.1223","article-title":"Pharmacokinetics of Teicoplanin in\nPediatric Patients","volume":"32","author":"Terragna","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"2026081410073338100_cit38","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1128\/AAC.31.4.612","article-title":"Absence of Ototoxicity\nof Teichomycin A2 in Guinea Pigs","volume":"31","author":"Brummett","year":"1987","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"5","key":"2026081410073338100_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2026.117286","article-title":"The Mycobacterial ATP Burst Is a Lysis Artifact and\nServes as an Assay for Drug-Induced Cell Wall Damage","volume":"45","author":"Mulholland","year":"2026","journal-title":"Cell Rep."},{"issue":"1","key":"2026081410073338100_cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000285","article-title":"Polar Localization\nof Virulence-Related Esx-1 Secretion in Mycobacteria","volume":"5","author":"Carlsson","year":"2009","journal-title":"PLoS Pathog."},{"issue":"6","key":"2026081410073338100_cit41","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1128\/AAC.49.6.2467-2473.2005","article-title":"Use of\nConfocal Microscopy To Analyze\nthe Rate of Vancomycin Penetration through Staphylococcus Aureus Biofilms","volume":"49","author":"Jefferson","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026081410073338100_cit42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37243","article-title":"Peptidoglycan Precursor Synthesis\nalong the Sidewall of Pole-Growing Mycobacteria","volume":"7","author":"Garci\u0301a-Heredia","year":"2018","journal-title":"eLife"},{"key":"2026081410073338100_cit43","unstructured":"Singh, A. K.; Malik, P.; Mukhopadhyay, A.; Imran, M.; Ahmad, M. N.; Ali, J.; Pramanik, S.; Maindolia, R.; Ghosh, A.; Karaulia, P.; Gupta, U. D.; Mitra, K.; Chopra, S.; Dasgupta, A.\n          In Vitro and in Vivo Synergy of Vancomycin and \u03b2-Lactams\nagainst Drug-Resistant Mycobacterium Tuberculosis and Non-Tuberculous\nMycobacteria.\n          bioRxiv [Preprint]\n          2025; p 2025.03.24.644967. 10.1101\/2025.03.24.644967."},{"issue":"4","key":"2026081410073338100_cit44","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1128\/AAC.01275-08","article-title":"A Novel Gene, Erm(41), Confers Inducible\nMacrolide Resistance to Clinical Isolates of Mycobacterium Abscessus\nbut Is Absent from Mycobacterium Chelonae","volume":"53","author":"Nash","year":"2009","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"8","key":"2026081410073338100_cit45","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s10096-011-1510-9","article-title":"The Use of a Two-Gene Sequencing\nApproach to Accurately\nDistinguish between the Species within the Mycobacterium Abscessus\nComplex and Mycobacterium Chelonae","volume":"31","author":"Blauwendraat","year":"2012","journal-title":"Eur. J.\nClin. Microbiol. Infect. Dis."},{"issue":"6","key":"2026081410073338100_cit46","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1348-0421.2010.00221.x","article-title":"Mycobacterium\nMassiliense Is Differentiated\nfrom Mycobacterium Abscessus and Mycobacterium Bolletii by Erythromycin\nRibosome Methyltransferase Gene (Erm) and Clarithromycin Susceptibility\nPatterns","volume":"54","author":"Kim","year":"2010","journal-title":"Microbiol. Immunol."},{"issue":"1","key":"2026081410073338100_cit47","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.chest.2017.04.166","article-title":"Microbiological\nand Clinical Outcomes of Treating Non-Mycobacterium Avium Complex Nontuberculous Mycobacterial\nPulmonary Disease: A Systematic Review and Meta-Analysis","volume":"152","author":"Diel","year":"2017","journal-title":"Chest"},{"issue":"3","key":"2026081410073338100_cit48","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/cid\/ciw723","article-title":"Progression and\nTreatment Outcomes of Lung Disease Caused by Mycobacterium Abscessus\nand Mycobacterium Massiliense","volume":"64","author":"Park","year":"2017","journal-title":"Clin. Infect.\nDis."},{"issue":"10","key":"2026081410073338100_cit49","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1128\/JCM.00319-08","article-title":"Proportions of Mycobacterium\nMassiliense and Mycobacterium Bolletii Strains among Korean Mycobacterium\nChelonae-Mycobacterium Abscessus Group Isolates","volume":"46","author":"Kim","year":"2008","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"2026081410073338100_cit50","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1099\/mic.0.2007\/012153-0","article-title":"EmbA Is an Essential\nArabinosyltransferase in Mycobacterium\nTuberculosis","volume":"154","author":"Amin","year":"2008","journal-title":"Microbiology"},{"issue":"52","key":"2026081410073338100_cit51","doi-asserted-by":"publisher","first-page":"48854","DOI":"10.1074\/jbc.M102272200","article-title":"The Role of\nthe embA and embB Gene Products in the\nBiosynthesis of the Terminal Hexaarabinofuranosyl Motif of Mycobacterium smegmatis Arabinogalactan","volume":"276","author":"Escuyer","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"2026081410073338100_cit52","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01049-21","article-title":"Genome-Wide\nEssentiality Analysis of Mycobacterium Abscessus by Saturated Transposon\nMutagenesis and Deep Sequencing","volume":"12","author":"Rifat","year":"2021","journal-title":"mBio"},{"issue":"10","key":"2026081410073338100_cit53","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1099\/00221287-148-10-3059","article-title":"Ligation of\nArabinogalactan to Peptidoglycan in the Cell Wall of Mycobacterium smegmatis Requires Concomitant Synthesis\nof the Two Wall Polymers","volume":"148","author":"Hancock","year":"2002","journal-title":"Microbiology"},{"issue":"4","key":"2026081410073338100_cit54","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00972-16","article-title":"Lcp1 Is a Phosphotransferase Responsible for Ligating\nArabinogalactan to Peptidoglycan in Mycobacterium Tuberculosis","volume":"7","author":"Harrison","year":"2016","journal-title":"mBio"},{"issue":"1","key":"2026081410073338100_cit55","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1128\/MMBR.00028-07","article-title":"Bacterial Growth\nand Cell Division: A Mycobacterial\nPerspective","volume":"72","author":"Hett","year":"2008","journal-title":"Microbiol. 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