{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:01:47Z","timestamp":1786719707055,"version":"build-2736575974"},"reference-count":165,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00c3\u00a7\u00c3\u00a3o de Aperfei\u00c3\u00a7oamento de Pessoal de N\u00c3\u00advel Superior (CAPES)"},{"name":"Funda\u00c3\u00a7\u00c3\u00a3o de Apoio ao Desenvolvimento do Ensino, Ci\u00c3\u00aancia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)"},{"name":"Funda\u00c3\u00a7\u00c3\u00a3o de Apoio \u00c3\u00a0 Pesquisa do Distrito Federal (FAPDF)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00c3\u00adfico e Tecnol\u00c3\u00b3gico (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Latin America\u2019s biodiversity accounts for approximately 60% of the world\u2019s total, fueling scientific research into natural products, a highly relevant area in drug discovery to this day. This is accompanied by an increasing number of antimicrobial peptides (AMPs) derived from natural products in the region, which over the past decade have been redesigned through modifications, enhancements, and refinements of their physicochemical properties and antimicrobial potency, using approaches that range from rational design and structure\u2013activity relationship (SAR) studies to artificial intelligence and machine learning methodologies. AMPs and their derivatives represent a vast chemical space with potential for antibacterial, antifungal, antiviral, and antiparasitic therapies, with emerging applications beyond infectious diseases. Over the years, studies have identified these peptides from a wide range of sources, including amphibians, reptiles, invertebrates, and microorganisms from South America, highlighting their diverse biological activities. This raises important questions about whether Latin America is a fertile source of inspiration for the development of AMPs. It also prompts an examination of the region\u2019s historical and ongoing contributions to the field of natural and synthetic AMPs with anti-infective potential. Additionally, it highlights the need to assess the region\u2019s progress in keeping pace with the recent advancements in engineering AMPs to combat resistant bacteria. This mini-review addresses these topics and related issues, exploring Latin America\u2019s discoveries, challenges, and innovations in AMPs and their applications, particularly in anti-infective agents.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00394","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:09:45Z","timestamp":1785848985000},"page":"2529-2557","source":"Crossref","is-referenced-by-count":0,"title":["Natural and\nSynthetic AMPs from Latin America across\nDiversity Engineering and Applications"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-9770","authenticated-orcid":true,"given":"Jose\u0301","family":"Brango-Vanegas","sequence":"first","affiliation":[{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , - ,","place":["Brasi\u0301lia, DF, Brazil, 71966-700"]},{"name":"Universidade Cato\u0301lica Dom Bosco , , - ,","place":["Campo Grande, MS, Brazil, 79117-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-029X","authenticated-orcid":true,"given":"Elizabete","family":"de Souza Ca\u0302ndido","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , - ,","place":["Brasi\u0301lia, DF, Brazil, 71966-700"]},{"name":"Universidade Cato\u0301lica Dom Bosco , , - ,","place":["Campo Grande, MS, Brazil, 79117-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica Dom Bosco , , - ,","place":["Campo Grande, MS, Brazil, 79117-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2040-8896","authenticated-orcid":true,"given":"Nanci","family":"Almeida Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , - ,","place":["Brasi\u0301lia, DF, Brazil, 71966-700"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-0525","authenticated-orcid":true,"given":"Octa\u0301vio Luiz","family":"Franco","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , - ,","place":["Brasi\u0301lia, DF, Brazil, 71966-700"]},{"name":"Universidade Cato\u0301lica Dom Bosco , , - ,","place":["Campo Grande, MS, Brazil, 79117-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"2026081410075475500_cit1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41579-024-01089-z","article-title":"Stronger Commitment and Faster Action against Antimicrobial Resistance","volume":"22","year":"2024","journal-title":"Nat. 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