{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:07:33Z","timestamp":1789135653466,"version":"build-2803163510"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103499"],"award-info":[{"award-number":["P20GM103499"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006807","name":"Furman University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100006807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To survive in glucose poor niches within the host, the opportunistic pathogen Nakaseomyces glabratus must assimilate alternative carbon sources. In many yeasts, pathways for alternative carbon metabolism are regulated at the transcriptional level by Zn2Cys6 transcription factors, a class of proteins that are unique to fungi. Here, we investigated the transcriptional regulation of alternative carbon metabolism pathways by the Zn2Cys6 transcription factors Cat8p, Sip4p, and Rds2p in the opportunistic pathogen N. glabratus. Phenotypic screens of transcription factor knockout strains grown on alternative carbon sources identified that deletion of CAT8, a transcription factor required for growth in the closely related model organisms Saccharomyces cerevisiae, did not affect the growth of N. glabratus, but deletion of SIP4 resulted in growth defects. We further probed the changes in gene expression that occur upon treatment with lactate or ethanol using RNA-seq. In the wild type strain, genes related to gluconeogenesis, the TCA cycle, and the glyoxylate cycle were upregulated in the presence of alternative carbon sources, and transcription of PCK1, encoding the gluconeogenesis enzyme phosphoenolpyruvate carboxykinase, was induced over 2000-fold. Deletion of SIP4 resulted in a 4-fold decrease in PCK1 gene expression in lactate and ethanol treated cells, and a 6-fold decrease in the cytosolic malate dehydrogenase MDH2 in lactate treated cells. Taken together, our results have uncovered transcriptional rewiring and a role for Sip4p in the regulation of alternative carbon metabolism in N. glabratus.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00455","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:02:08Z","timestamp":1786446128000},"page":"3204-3216","source":"Crossref","is-referenced-by-count":0,"title":["Sip4p Regulates\nthe Transcription of Enzymes for Gluconeogenesis\nin\n                    <i>Nakaseomyces glabratus<\/i>"],"prefix":"10.1021","volume":"12","author":[{"given":"Ryan J.","family":"Galloway","sequence":"first","affiliation":[{"name":"Furman University , , 3300 Poinsett Hwy , , ,","place":["Greenville, South Carolina, United States, 29613"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria J.","family":"Walgren","sequence":"additional","affiliation":[{"name":"Furman University , , 3300 Poinsett Hwy , , ,","place":["Greenville, South Carolina, United States, 29613"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra M.","family":"Naeem","sequence":"additional","affiliation":[{"name":"Furman University , , 3300 Poinsett Hwy , , ,","place":["Greenville, South Carolina, United States, 29613"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana C.","family":"Geiger","sequence":"additional","affiliation":[{"name":"Furman University , , 3300 Poinsett Hwy , , ,","place":["Greenville, South Carolina, United States, 29613"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-8533","authenticated-orcid":true,"given":"Meghan E.","family":"Breen","sequence":"additional","affiliation":[{"name":"Furman University , , 3300 Poinsett Hwy , , ,","place":["Greenville, South Carolina, United States, 29613"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"1","key":"2026091109100168200_cit1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/acsinfecdis.4c00477","article-title":"Candida glabrata: A Tale of Stealth and Endurance","volume":"11","author":"Askari","year":"2025","journal-title":"ACS Infect. Dis."},{"issue":"2","key":"2026091109100168200_cit2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/microorganisms7020039","article-title":"Candida glabrata:\nA\nLot More Than Meets the Eye","volume":"7","author":"Kumar","year":"2019","journal-title":"Microorganisms"},{"key":"2026091109100168200_cit3","doi-asserted-by":"publisher","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev.\nDis Primers"},{"issue":"1","key":"2026091109100168200_cit4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1186\/1471-2164-14-623","article-title":"Comparative genomics of emerging\npathogens in the Candida glabrata clade","volume":"14","author":"Gabaldo\u0301n","year":"2013","journal-title":"BMC\nGenomics"},{"issue":"2","key":"2026091109100168200_cit5","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00021-23","article-title":"Candida albicans\nand Candida glabrata: global priority\npathogens","volume":"88","author":"Katsipoulaki","year":"2024","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"5","key":"2026091109100168200_cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008478","article-title":"Adapting to survive: How Candida\novercomes host-imposed constraints during human colonization","volume":"16","author":"Alves","year":"2020","journal-title":"PLoS Pathog."},{"issue":"12","key":"2026091109100168200_cit7","doi-asserted-by":"publisher","first-page":"a019695","DOI":"10.1101\/cshperspect.a019695","article-title":"Metabolism\nin fungal\npathogenesis","volume":"4","author":"Ene","year":"2014","journal-title":"Cold Spring Harb Perspect Med."},{"issue":"5","key":"2026091109100168200_cit8","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ijmm.2011.04.007","article-title":"Nutrient acquisition\nby pathogenic\nfungi: nutrient availability, pathway regulation, and differences\nin substrate utilization","volume":"301","author":"Fleck","year":"2011","journal-title":"Int. J. Med. Microbiol."},{"issue":"12","key":"2026091109100168200_cit9","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1128\/EC.00172-10","article-title":"Intracellular acetyl\nunit transport in fungal carbon\nmetabolism","volume":"9","author":"Strijbis","year":"2010","journal-title":"Eukaryot. Cell"},{"issue":"1","key":"2026091109100168200_cit10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12929-019-0546-5","article-title":"The glyoxylate\ncycle and alternative\ncarbon metabolism as metabolic adaptation strategies of Candida glabrata:\nperspectives from Candida albicans and Saccharomyces cerevisiae","volume":"26","author":"Chew","year":"2019","journal-title":"J. Biomed Sci."},{"issue":"1","key":"2026091109100168200_cit11","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1080\/21505594.2022.2095716","article-title":"Using in vivo transcriptomics\nand RNA enrichment to identify genes involved in virulence of Candida\nglabrata","volume":"13","author":"Schrevens","year":"2022","journal-title":"Virulence"},{"issue":"1","key":"2026091109100168200_cit12","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41598-019-39117-1","article-title":"Glyoxylate\ncycle gene ICL1 is essential\nfor the metabolic flexibility and virulence of Candida glabrata","volume":"9","author":"Chew","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"2026091109100168200_cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024759","article-title":"Intestinal\nResident Yeast Candida\nglabrata Requires Cyb2p-Mediated Lactate Assimilation to Adapt in\nMouse Intestine","volume":"6","author":"Ueno","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"2026091109100168200_cit14","doi-asserted-by":"publisher","first-page":"e03317","DOI":"10.1128\/mbio.03317-21","article-title":"Interactions of\nBoth Pathogenic and Nonpathogenic CUG Clade Candida Species with Macrophages\nShare a Conserved Transcriptional Landscape","volume":"12","author":"Pountain","year":"2021","journal-title":"mBio"},{"issue":"6","key":"2026091109100168200_cit15","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/j.1462-5822.2005.00676.x","article-title":"Niche-specific regulation of central metabolic pathways\nin a fungal pathogen","volume":"8","author":"Barelle","year":"2006","journal-title":"Cell. Microbiol."},{"issue":"6842","key":"2026091109100168200_cit16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/35083594","article-title":"The glyoxylate cycle\nis required for fungal virulence","volume":"412","author":"Lorenz","year":"2001","journal-title":"Nature"},{"key":"2026091109100168200_cit17","doi-asserted-by":"publisher","first-page":"16238","DOI":"10.1038\/nmicrobiol.2016.238","article-title":"Lactate signalling\nregulates fungal \u03b2-glucan masking and immune evasion","volume":"2","author":"Ballou","year":"2017","journal-title":"Nat. Microbiol."},{"issue":"5","key":"2026091109100168200_cit18","doi-asserted-by":"publisher","first-page":"fov042","DOI":"10.1093\/femsyr\/fov042","article-title":"Intracellular\nsurvival of Candida\nglabrata in macrophages: immune evasion and persistence","volume":"15","author":"Kasper","year":"2015","journal-title":"FEMS Yeast Res."},{"issue":"18","key":"2026091109100168200_cit19","doi-asserted-by":"publisher","first-page":"7628","DOI":"10.1073\/pnas.0611195104","article-title":"A family of glycosylphosphatidylinositol-linked aspartyl\nproteases is required for virulence of Candida glabrata","volume":"104","author":"Kaur","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"2026091109100168200_cit20","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1128\/EC.00262-13","article-title":"Immune evasion,\nstress resistance,\nand efficient nutrient acquisition are crucial for intracellular survival\nof Candida glabrata within macrophages","volume":"13","author":"Seider","year":"2014","journal-title":"Eukaryot.\nCell"},{"issue":"8","key":"2026091109100168200_cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002863","article-title":"Functional\ngenomic analysis of Candida glabrata-macrophage interaction: role\nof chromatin remodeling in virulence","volume":"8","author":"Rai","year":"2012","journal-title":"PLoS Pathog."},{"issue":"6","key":"2026091109100168200_cit22","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.4049\/jimmunol.1003730","article-title":"The facultative\nintracellular\npathogen Candida glabrata subverts macrophage cytokine production\nand phagolysosome maturation","volume":"187","author":"Seider","year":"2011","journal-title":"J. Immunol."},{"issue":"4","key":"2026091109100168200_cit23","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1128\/IAI.00851-12","article-title":"Transcriptional\nprofiling of Candida glabrata during phagocytosis by neutrophils and\nin the infected mouse spleen","volume":"81","author":"Fukuda","year":"2013","journal-title":"Infect. Immun."},{"issue":"1","key":"2026091109100168200_cit24","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12866-024-03274-9","article-title":"Decoding the\nrole of oxidative stress resistance and alternative carbon substrate\nassimilation in the mature biofilm growth mode of Candida glabrata","volume":"24","author":"Raj","year":"2024","journal-title":"BMC Microbiol."},{"issue":"1","key":"2026091109100168200_cit25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1567-1364.2009.00555.x","article-title":"Transcriptional\nregulation of nonfermentable carbon utilization in budding yeast","volume":"10","author":"Turcotte","year":"2010","journal-title":"FEMS Yeast Res."},{"issue":"1","key":"2026091109100168200_cit26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00294-016-0609-z","article-title":"Reprogramming\nof nonfermentative metabolism by stress-responsive transcription factors\nin the yeast Saccharomyces cerevisiae","volume":"63","author":"Soontorngun","year":"2017","journal-title":"Curr.\nGenet."},{"issue":"3","key":"2026091109100168200_cit27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00294-003-0381-8","article-title":"Transcriptional\ncontrol of nonfermentative metabolism in the yeast Saccharomyces cerevisiae","volume":"43","author":"Schu\u0308ller","year":"2003","journal-title":"Curr. Genet."},{"issue":"3","key":"2026091109100168200_cit28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1128\/MMBR.00015-06","article-title":"A fungal family of\ntranscriptional\nregulators: the zinc cluster proteins","volume":"70","author":"MacPherson","year":"2006","journal-title":"Microbiol.\nMol. Biol. Rev."},{"issue":"4","key":"2026091109100168200_cit29","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1128\/MCB.15.4.1915","article-title":"CAT8, a new zinc cluster-encoding\ngene necessary for derepression of gluconeogenic enzymes in the yeast\nSaccharomyces cerevisiae","volume":"15","author":"Hedges","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"2026091109100168200_cit30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1074\/jbc.M008752200","article-title":"The transcriptional\nactivator Cat8p\nprovides a major contribution to the reprogramming of carbon metabolism\nduring the diauxic shift in Saccharomyces cerevisiae","volume":"276","author":"Haurie","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"12","key":"2026091109100168200_cit31","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1093\/nar\/24.12.2331","article-title":"Dual influence of the yeast Cat1p (Snf1p) protein kinase\non carbon source-dependent transcriptional activation of gluconeogenic\ngenes by the regulatory gene CAT8","volume":"24","author":"Rahner","year":"1996","journal-title":"Nucleic Acids\nRes."},{"issue":"5","key":"2026091109100168200_cit32","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1128\/MCB.17.5.2502","article-title":"Glucose derepression\nof gluconeogenic enzymes in Saccharomyces cerevisiae correlates with\nphosphorylation of the gene activator Cat8p","volume":"17","author":"Randez-Gil","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"2026091109100168200_cit33","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1128\/MCB.25.6.2138-2146.2005","article-title":"Combined global localization analysis\nand transcriptome data identify genes that are directly coregulated\nby Adr1 and Cat8","volume":"25","author":"Tachibana","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"2026091109100168200_cit34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00294-003-0476-2","article-title":"Transcriptional\nactivators Cat8 and\nSip4 discriminate between sequence variants of the carbon source-responsive\npromoter element in the yeast Saccharomyces cerevisiae","volume":"45","author":"Roth","year":"2004","journal-title":"Curr. Genet."},{"issue":"2","key":"2026091109100168200_cit35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/1097-0061(20010130)18:2&lt;151::AID-YEA662&gt;3.0.CO;2-Q","article-title":"Cat8 and Sip4 mediate regulated transcriptional\nactivation\nof the yeast malate dehydrogenase gene MDH2 by three carbon source-responsive\npromoter elements","volume":"18","author":"Roth","year":"2001","journal-title":"Yeast"},{"issue":"22","key":"2026091109100168200_cit36","doi-asserted-by":"publisher","first-page":"7895","DOI":"10.1128\/MCB.01055-07","article-title":"Regulation\nof gluconeogenesis in Saccharomyces cerevisiae is mediated by activator\nand repressor functions of Rds2","volume":"27","author":"Soontorngun","year":"2007","journal-title":"Mol. Cell.\nBiol."},{"issue":"5","key":"2026091109100168200_cit37","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1093\/nar\/gkad1185","article-title":"Yeast zinc cluster transcription factors involved in\nthe switch from fermentation to respiration show interdependency for\nDNA binding revealing a novel type of DNA recognition","volume":"52","author":"Martinez","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2026091109100168200_cit38","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.bbrc.2012.05.151","article-title":"Genome-wide location analysis reveals\nan important overlap between the targets of the yeast transcriptional\nregulators Rds2 and Adr1","volume":"423","author":"Soontorngun","year":"2012","journal-title":"Biochem. Biophys.\nRes. Commun."},{"issue":"10","key":"2026091109100168200_cit39","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1093\/nar\/29.10.2181","article-title":"Phenotypic\nanalysis of genes encoding yeast zinc cluster\nproteins","volume":"29","author":"Akache","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2026091109100168200_cit40","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s002940000182","article-title":"Contribution\nof Cat8 and Sip4 to the transcriptional activation of yeast gluconeogenic\ngenes by carbon source-responsive elements","volume":"39","author":"Hiesinger","year":"2001","journal-title":"Curr. Genet."},{"issue":"2","key":"2026091109100168200_cit41","doi-asserted-by":"publisher","first-page":"fou002","DOI":"10.1093\/femsyr\/fou002","article-title":"Zinc cluster\nprotein Znf1, a novel transcription factor\nof non-fermentative metabolism in Saccharomyces cerevisiae","volume":"15","author":"Tangsombatvichit","year":"2015","journal-title":"FEMS Yeast Res."},{"issue":"3","key":"2026091109100168200_cit42","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/j.1432-1033.1997.00776.x","article-title":"A heterodimer\nof the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction\nof genes encoding peroxisomal proteins in Saccharomyces cerevisiae","volume":"247","author":"Rottensteiner","year":"1997","journal-title":"Eur. J. Biochem."},{"issue":"12","key":"2026091109100168200_cit43","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1002\/j.1460-2075.1996.tb00655.x","article-title":"Pip2p: a transcriptional\nregulator\nof peroxisome proliferation in the yeast Saccharomyces cerevisiae","volume":"15","author":"Rottensteiner","year":"1996","journal-title":"EMBO J."},{"issue":"16","key":"2026091109100168200_cit44","doi-asserted-by":"publisher","first-page":"10264","DOI":"10.1074\/jbc.M708215200","article-title":"Binding characteristics\nand regulatory mechanisms of the transcription factors controlling\noleate-responsive genes in Saccharomyces cerevisiae","volume":"283","author":"Karpichev","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"2026091109100168200_cit45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1128\/MCB.17.1.69","article-title":"A complex containing two transcription\nfactors regulates peroxisome proliferation and the coordinate induction\nof beta-oxidation enzymes in Saccharomyces cerevisiae","volume":"17","author":"Karpichev","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"2026091109100168200_cit46","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.bbrc.2014.06.128","article-title":"The novel zinc cluster regulator\nTog1 plays important roles in oleate utilization and oxidative stress\nresponse in Saccharomyces cerevisiae","volume":"450","author":"Thepnok","year":"2014","journal-title":"Biochem.\nBiophys. Res. Commun."},{"issue":"7","key":"2026091109100168200_cit47","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1128\/mcb.11.7.3762-3772.1991","article-title":"Complex transcriptional regulation\nof the Saccharomyces\ncerevisiae CYB2 gene encoding cytochrome b2: CYP1(HAP1) activator\nbinds to the CYB2 upstream activation site UAS1-B2","volume":"11","author":"Lodi","year":"1991","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"2026091109100168200_cit48","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1046\/j.1365-2958.2000.02065.x","article-title":"Regulation\nof the CYB2 gene expression: transcriptional co-ordination by the\nHap1p, Hap2\/3\/4\/5p and Adr1p transcription factors","volume":"37","author":"Ramil","year":"2000","journal-title":"Mol. Microbiol."},{"issue":"1","key":"2026091109100168200_cit49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1099\/00221287-144-1-13","article-title":"Glucose control\nin Saccharomyces\ncerevisiae: the role of MIG1 in metabolic functions","volume":"144","author":"Klein","year":"1998","journal-title":"Microbiology"},{"issue":"12","key":"2026091109100168200_cit50","doi-asserted-by":"publisher","first-page":"5696","DOI":"10.1128\/mcb.9.12.5696-5701.1989","article-title":"Isolation and analysis of the acetate\nregulatory gene,\nfacB, from Aspergillus nidulans","volume":"9","author":"Katz","year":"1989","journal-title":"Mol. Cell.\nBiol."},{"issue":"1","key":"2026091109100168200_cit51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1534\/genetics.107.070904","article-title":"Transcriptional control of gluconeogenesis in Aspergillus\nnidulans","volume":"176","author":"Hynes","year":"2007","journal-title":"Genetics"},{"issue":"10","key":"2026091109100168200_cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139464","article-title":"Divergent Evolution\nof the Transcriptional Network Controlled by Snf1-Interacting Protein\nSip4 in Budding Yeasts","volume":"10","author":"Mehlgarten","year":"2015","journal-title":"PLoS One"},{"issue":"1\u20132","key":"2026091109100168200_cit53","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s004380000314","article-title":"Differences\nin regulation of yeast gluconeogenesis revealed by Cat8p-independent\nactivation of PCK1 and FBP1 genes in Kluyveromyces lactis","volume":"264","author":"Georis","year":"2000","journal-title":"Mol. Gen. Genet."},{"issue":"10","key":"2026091109100168200_cit54","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1128\/EC.00206-09","article-title":"The transcription factor homolog CTF1 regulates {beta}-oxidation\nin Candida albicans","volume":"8","author":"Rami\u0301rez","year":"2009","journal-title":"Eukaryot. Cell"},{"issue":"1","key":"2026091109100168200_cit55","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/mmi.15015","article-title":"Zcf24, a zinc-finger\ntranscription factor, is required for lactate catabolism and inhibits\ncommensalism in Candida albicans","volume":"119","author":"Sun","year":"2023","journal-title":"Mol. Microbiol."},{"issue":"1","key":"2026091109100168200_cit56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2010.02102.x","article-title":"From Saccharomyces cerevisiae to\nCandida glabratain a few easy steps: important adaptations for an\nopportunistic pathogen","volume":"314","author":"Roetzer","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"issue":"1","key":"2026091109100168200_cit57","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1080\/21505594.2020.1839231","article-title":"A new regulator\nin the crossroads of oxidative stress resistance and virulence in\nCandida glabrata: The transcription factor CgTog1","volume":"11","author":"Pais","year":"2020","journal-title":"Virulence"},{"issue":"1","key":"2026091109100168200_cit58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-020-00700-8","article-title":"Transcriptomic\nand proteomic profiling revealed reprogramming of carbon metabolism\nin acetate-grown human pathogen Candida glabrata","volume":"28","author":"Chew","year":"2021","journal-title":"J. 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