{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:01:04Z","timestamp":1786719664469,"version":"build-2736575974"},"reference-count":2,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since Fleming\u2019s discovery of penicillin, antibiotic resistance has remained an inevitable biological reality; however, our guidelines and diagnostic practices are not keeping pace with the rising medical need. This viewpoint uses a real family case of recurrent Group C streptococcal pharyngitis to illustrate these gaps in an outpatient setting. The situation is obviously more dire with life threatening infections. Addressing the fragile antibiotic pipeline requires updated, accessible guidelines, routine culturing upon relapse, and public education to support fair pricing and sustained investment in novel antibiotics and companion diagnostics.<\/jats:p>","DOI":"10.1021\/acsinfecdis.6c00637","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:08:54Z","timestamp":1785848934000},"page":"2413-2415","source":"Crossref","is-referenced-by-count":0,"title":["Perseverance:\nWe Should Continue to Strive for Novel\nAntibiotics and Companion Diagnostics"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-7422","authenticated-orcid":true,"given":"Ruben A.","family":"Tommasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"2","key":"2026081410074291600_cit1","first-page":"89","article-title":"Personal\nRecollections of Sir Almroth Wright and Sir Alexander Fleming","volume":"3","author":"Allison","year":"1974","journal-title":"The Ulster Medical Journal"},{"issue":"49","key":"2026081410074291600_cit2","doi-asserted-by":"publisher","first-page":"2411919121","DOI":"10.1073\/pnas.2411919121","article-title":"Global trends\nin antibiotic consumption during 2016\u20132023 and future projections\nthrough 2030","volume":"121","author":"Klein","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.6c00637","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2413\/66286182\/acsinfecdis.6c00637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/12\/8\/2413\/66286182\/acsinfecdis.6c00637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:14:21Z","timestamp":1786716861000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/12\/8\/2413\/5234313\/Perseverance-We-Should-Continue-to-Strive-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":2,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,27]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.6c00637","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}