{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:11:18Z","timestamp":1767276678143,"version":"3.37.3"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"4","funder":[{"DOI":"10.13039\/100008637","name":"Center for Strategic Scientific Initiatives, National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA177402"],"award-info":[{"award-number":["R21CA177402"]}],"id":[{"id":"10.13039\/100008637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI089441","R01AI111341","R21AI123690"],"award-info":[{"award-number":["R01AI089441","R01AI111341","R21AI123690"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD080670"],"award-info":[{"award-number":["R01HD080670"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2018,4,13]]},"DOI":"10.1021\/acsinfecdis.7b00224","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T21:52:49Z","timestamp":1520632369000},"page":"516-522","source":"Crossref","is-referenced-by-count":6,"title":["7<i>H<\/i>-Pyrrolo[2,3-<i>d<\/i>]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1<i>H<\/i>-Pyrazolo[3,4-<i>d<\/i>]pyrimidin-4-amine-Based Inhibitors"],"prefix":"10.1021","volume":"4","author":[{"given":"Rama S. R.","family":"Vidadala","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Washington, 36 Bagley Hall, Box 351700, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-1655","authenticated-orcid":true,"given":"Martin","family":"Golkowski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Box 357280, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Hulverson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly C.","family":"McCloskey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant R.","family":"Whitman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel L. M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn K.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan A.","family":"Merritt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley C.","family":"Van Voorhis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-2170","authenticated-orcid":true,"given":"Kayode K.","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-0177","authenticated-orcid":true,"given":"Dustin J.","family":"Maly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, 36 Bagley Hall, Box 351700, Seattle, Washington 98195, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70772-8"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328357e569"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0056-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1086\/428839"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ml100096t"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit327"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw481"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw488"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00020-17"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix120"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2017.08.006"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00760"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00817"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jm1013693"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7154-1_8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00315A"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix247"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-47-1-71"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1818"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182014000857"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.10.014"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.7b00224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:05:15Z","timestamp":1682294715000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.7b00224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4,13]]}},"alternative-id":["10.1021\/acsinfecdis.7b00224"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.7b00224","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"type":"print","value":"2373-8227"},{"type":"electronic","value":"2373-8227"}],"subject":[],"published":{"date-parts":[[2018,3,9]]}}}