{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:34:39Z","timestamp":1792679679248,"version":"4.5.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000082","name":"Division of Graduate Education","doi-asserted-by":"publisher","award":["DGE-1656466"],"award-info":[{"award-number":["DGE-1656466"]}],"id":[{"id":"10.13039\/100000082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1150755"],"award-info":[{"award-number":["OPP1150755"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malaria poses a major burden on human health and is becoming increasingly difficult to treat due to the development of antimalarial drug resistance. The resistance issue is further exacerbated by a lack of patient adherence to multi-day dosing regimens. This situation motivates the development of new antimalarial treatments that are less susceptible to the development of resistance. We have applied Flash NanoPrecipitation (FNP), a polymer-directed self-assembly process, to form stable, water-dispersible nanoparticles (NPs) of 50\u2013400 nm in size containing OZ439, a poorly orally bioavailable but promising candidate for single-dose malaria treatment developed by Medicines for Malaria Venture (MMV). During the FNP process, a hydrophobic OZ439 oleate ion paired complex was formed and was encapsulated into NPs. Lyophilization conditions for the NP suspension were optimized to produce a dry powder. The in vitro release rates of OZ439 encapsulated in this powder were determined in biorelevant media and compared with the release rates of the unencapsulated drug. The OZ439 NPs exhibit a sustained release profile and several-fold higher release concentrations compared to that of the unencapsulated drug. In addition, XRD suggests the drug was stabilized into an amorphous form within the NPs, which may explain the improvement in dissolution kinetics. Formulating OZ439 into NPs in this way may be an important step toward developing a single-dose oral malaria therapeutic, and offers the possibility of reducing the amount of drug required per patient, lowering delivery costs, and improving dosing compliance.<\/jats:p>","DOI":"10.1021\/acsinfecdis.7b00278","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:22:05Z","timestamp":1522027325000},"page":"970-979","source":"Crossref","is-referenced-by-count":29,"title":["Encapsulation of OZ439 into Nanoparticles for Supersaturated\nDrug Release in Oral Malaria Therapy"],"prefix":"10.1021","volume":"4","author":[{"given":"Hoang D.","family":"Lu","sequence":"first","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt D.","family":"Ristroph","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L. K.","family":"Dobrijevic","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1714-1259","authenticated-orcid":true,"given":"Simon A.","family":"McManus","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Mulhearn","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanu","family":"Ramachandruni","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture , Route de Pre\u0301-Bois 20 , ,","place":["Meyrin, Switzerland, 1215"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Patel","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture , Route de Pre\u0301-Bois 20 , ,","place":["Meyrin, Switzerland, 1215"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Prud\u2019homme","sequence":"additional","affiliation":[{"name":"Princeton University , , A301 Engineering Quadrangle, Olden Street , , ,","place":["Princeton, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"2026090304030577400_cit1","unstructured":"WHO.\n          \n          World\nMalaria report, 2016, http:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2016\/report\/en\/."},{"issue":"10","key":"2026090304030577400_cit2","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1016\/j.bmcl.2013.03.067","article-title":"Recent\nadvances in malaria drug discovery","volume":"23","author":"Biamonte","year":"2013","journal-title":"Bioorg.\nMed. Chem. Lett."},{"issue":"2","key":"2026090304030577400_cit3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4269\/ajtmh.2012.12-0025","article-title":"Artemisinin-Resistant\nMalaria: Research Challenges,\nOpportunities, and Public Health Implications","volume":"87","author":"Fairhurst","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"5","key":"2026090304030577400_cit4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0165-6147(99)01302-4","article-title":"Artemisinin\ndrugs in the treatment of malaria: from medicinal herb to registered\nmedication","volume":"20","author":"Van Agtmael","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"2026090304030577400_cit5","unstructured":"Bill & Melinda Gates Foundation.\n          \n          http:\/\/www.gatesfoundation.org\/What-We-Do\/Global-Health\/Malaria (accessed Mar 16, 2017)."},{"issue":"4","key":"2026090304030577400_cit6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/S1461-5347(00)00247-9","article-title":"Recent technological advances in\noral drug delivery - a review","volume":"3","author":"Sastry","year":"2000","journal-title":"Pharm. Sci. Technol.\nToday"},{"issue":"11","key":"2026090304030577400_cit7","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1021\/js980076h","article-title":"Novel approaches\nfor oral delivery of macromolecules","volume":"87","author":"Fasano","year":"1998","journal-title":"J. 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