{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:45:10Z","timestamp":1793684710265,"version":"4.5.1"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2020,6,12]]},"DOI":"10.1021\/acsinfecdis.9b00127","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T11:24:15Z","timestamp":1565609055000},"page":"1480-1489","source":"Crossref","is-referenced-by-count":24,"title":["Structural and Biological Basis of Small Molecule Inhibition of <i>Escherichia coli<\/i> LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-827X","authenticated-orcid":true,"given":"Xiaolei","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadevi","family":"Prathapam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wartchow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Chie-Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Min","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"De Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseok","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-4400","authenticated-orcid":true,"given":"Yipin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-5309","authenticated-orcid":true,"given":"Savithri","family":"Ramurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Shia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah","family":"Steffek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-4286","authenticated-orcid":true,"given":"Tsuyoshi","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00117-14"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.06.044"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.010307.145803"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.05.004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265576"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.22.7090-7097.1992"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"19866","DOI":"10.1016\/S0021-9258(19)36593-7","volume":"268","author":"Kelly T. M.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422186112"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419677112"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2017.11.001"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611594113"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13872"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00834-10"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01597-13"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1460187"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bi901025v"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/bi800240r"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nature12679"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/cb300094a"},{"key":"ref21\/cit21","unstructured":"Jenkins, R. J. (2013)  Phage Display as a tool for probing lipid A biosynthesis, PhD dissertation. Retrieved from University of Michigan Deep Blue database (Handle: http:\/\/hdl.handle.net\/2027.42\/98051)."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606356104"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309111018811"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309112048890"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4572"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00083"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jm700967e"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"32896","DOI":"10.1016\/S0021-9258(20)30075-2","volume":"269","author":"Mohan S.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00746.x"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1793-1799.2002"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01551-14"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.447607"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00508-18"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.564278"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.03.028"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.2937"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444911007773"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"ref39\/cit39","unstructured":"Womack, T., Smart, O., Sharff, A., Flensburg, C., Keller, P., Paciorek, W., Vonrhein, C., and Bricogne, G. (2011)  Rhofit, version 1.2.5, Global Phasing Ltd, Cambridge, United Kingdom."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T11:28:08Z","timestamp":1682249288000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.9b00127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,12]]}},"alternative-id":["10.1021\/acsinfecdis.9b00127"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00127","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}