{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:22:29Z","timestamp":1794244949340,"version":"4.9.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["ECHO-711.017.002"],"award-info":[{"award-number":["ECHO-711.017.002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VICI-91812628"],"award-info":[{"award-number":["VICI-91812628"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Enteroviruses (family Picornaviridae) comprise a large group of human pathogens against which no licensed antiviral therapy exists. Drug-repurposing screens uncovered the FDA-approved drug fluoxetine as a replication inhibitor of enterovirus B and D species. Fluoxetine likely targets the nonstructural viral protein 2C, but detailed mode-of-action studies are missing because structural information on 2C of fluoxetine-sensitive enteroviruses is lacking. We here show that broad-spectrum anti-enteroviral activity of fluoxetine is stereospecific concomitant with binding to recombinant 2C. (S)-Fluoxetine inhibits with a 5-fold lower 50% effective concentration (EC50) than racemic fluoxetine. Using a homology model of 2C of the fluoxetine-sensitive enterovirus coxsackievirus B3 (CVB3) based upon a recently elucidated structure of a fluoxetine-insensitive enterovirus, we predicted stable binding of (S)-fluoxetine. Structure-guided mutations disrupted binding and rendered coxsackievirus B3 (CVB3) resistant to fluoxetine. The study provides new insights into the anti-enteroviral mode-of-action of fluoxetine. Importantly, using only (S)-fluoxetine would allow for lower dosing in patients, thereby likely reducing side effects.<\/jats:p>","DOI":"10.1021\/acsinfecdis.9b00179","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T12:01:25Z","timestamp":1563192085000},"page":"1609-1623","source":"Crossref","is-referenced-by-count":81,"title":["Fluoxetine Inhibits Enterovirus Replication by Targeting\nthe Viral 2C Protein in a Stereospecific Manner"],"prefix":"10.1021","volume":"5","author":[{"given":"Lisa","family":"Bauer","sequence":"first","affiliation":[{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Manganaro","sequence":"additional","affiliation":[{"name":"Cardiff University , , King Edward VII Avenue , ,","place":["Cardiff, United Kingdom, CF10 3NB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Zonsics","sequence":"additional","affiliation":[{"name":"Cardiff University , , King Edward VII Avenue , ,","place":["Cardiff, United Kingdom, CF10 3NB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen R. P. M.","family":"Strating","sequence":"additional","affiliation":[{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"El Kazzi","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universite\u0301 , , Case 925, 163 Avenue de Luminy , ,","place":["Marseille, France, 3288 CEDEX 9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Lorenzo Lopez","sequence":"additional","affiliation":[{"name":"Cardiff University , , King Edward VII Avenue , ,","place":["Cardiff, United Kingdom, CF10 3NB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Ulferts","sequence":"additional","affiliation":[{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"van Hoey","sequence":"additional","affiliation":[{"name":"University of Vienna , , Althanstra\u00dfe 14 , ,","place":["Vienna, Austria, A-1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Mate\u0301","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universite\u0301 , , Case 925, 163 Avenue de Luminy , ,","place":["Marseille, France, 3288 CEDEX 9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-1240","authenticated-orcid":true,"given":"Thierry","family":"Langer","sequence":"additional","affiliation":[{"name":"University of Vienna , , Althanstra\u00dfe 14 , ,","place":["Vienna, Austria, A-1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Coutard","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universite\u0301 , , Case 925, 163 Avenue de Luminy , ,","place":["Marseille, France, 3288 CEDEX 9"]},{"name":"Unite\u0301 des Virus Emergents , , , CEDEX 5,","place":["Marseille, France, 13385"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-3419","authenticated-orcid":true,"given":"Andrea","family":"Brancale","sequence":"additional","affiliation":[{"name":"Cardiff University , , King Edward VII Avenue , ,","place":["Cardiff, United Kingdom, CF10 3NB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-749X","authenticated-orcid":true,"given":"Frank J. M.","family":"van Kuppeveld","sequence":"additional","affiliation":[{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"2026090313165305400_cit1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.meegid.2012.10.016","article-title":"Picornavirus and enterovirus diversity with associated\nhuman diseases","volume":"14","author":"Tapparel","year":"2013","journal-title":"Infect., Genet. Evol."},{"key":"2026090313165305400_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coviro.2017.03.009","article-title":"Direct-acting\nantivirals and host-targeting strategies to combat enterovirus infections","volume":"24","author":"Bauer","year":"2017","journal-title":"Curr. Opin. Virol."},{"issue":"11","key":"2026090313165305400_cit3","doi-asserted-by":"crossref","first-page":"8105","DOI":"10.1016\/S0021-9258(18)53068-4","article-title":"Poliovirus protein 2C has ATPase\nand GTPase activities","volume":"268","author":"Rodriguez","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"11","key":"2026090313165305400_cit4","doi-asserted-by":"publisher","first-page":"6992","DOI":"10.1074\/jbc.274.11.6992","article-title":"Characterization of\nthe nucleoside triphosphatase activity of poliovirus protein 2C reveals\na mechanism by which guanidine inhibits poliovirus replication","volume":"274","author":"Pfister","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"2","key":"2026090313165305400_cit5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0168-1702(99)00110-0","article-title":"Echovirus\n9 strain barty non-structural protein 2C has NTPase activity","volume":"65","author":"Klein","year":"1999","journal-title":"Virus Res."},{"issue":"7","key":"2026090313165305400_cit6","doi-asserted-by":"publisher","first-page":"e1005067","DOI":"10.1371\/journal.ppat.1005067","article-title":"Human Enterovirus Nonstructural\nProtein 2CATPase Functions as Both an RNA Helicase and ATP-Independent\nRNA Chaperone","volume":"11","author":"Xia","year":"2015","journal-title":"PLoS Pathog."},{"key":"2026090313165305400_cit7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.biochem.76.052305.115300","article-title":"Structure and mechanism of helicases and nucleic acid\ntranslocases","volume":"76","author":"Singleton","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"3","key":"2026090313165305400_cit8","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1128\/jvi.64.3.1102-1107.1990","article-title":"An intragenic\nrevertant of a poliovirus 2C mutant has an uncoating defect","volume":"64","author":"Li","year":"1990","journal-title":"J. Virol."},{"issue":"1","key":"2026090313165305400_cit9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1006\/viro.1994.1329","article-title":"Membrane rearrangement\nand vesicle induction by recombinant poliovirus 2C and 2BC in human\ncells","volume":"202","author":"Cho","year":"1994","journal-title":"Virology"},{"issue":"1","key":"2026090313165305400_cit10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1006\/bbrc.1995.1010","article-title":"Induction of membrane\nproliferation by poliovirus proteins 2C and 2BC","volume":"206","author":"Aldabe","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"2026090313165305400_cit11","doi-asserted-by":"crossref","first-page":"8962","DOI":"10.1128\/jvi.71.12.8962-8972.1997","article-title":"Poliovirus\n2C protein determinants of membrane binding and rearrangements in\nmammalian cells","volume":"71","author":"Teterina","year":"1997","journal-title":"J. Virol."},{"issue":"19","key":"2026090313165305400_cit12","doi-asserted-by":"publisher","first-page":"8953","DOI":"10.1128\/JVI.74.19.8953-8965.2000","article-title":"Remodeling the endoplasmic reticulum by poliovirus\ninfection and by individual viral proteins: an autophagy-like origin\nfor virus-induced vesicles","volume":"74","author":"Suhy","year":"2000","journal-title":"J. Virol."},{"issue":"12","key":"2026090313165305400_cit13","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.1128\/jvi.71.12.9570-9578.1997","article-title":"Poliovirus-encoded 2C polypeptide\nspecifically binds to the 3\u2032-terminal sequences of viral negative-strand\nRNA","volume":"71","author":"Banerjee","year":"1997","journal-title":"J. Virol."},{"issue":"11","key":"2026090313165305400_cit14","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1099\/0022-1317-82-11-2621","article-title":"Interaction of picornavirus\n2C polypeptide with the viral negative-strand RNA","volume":"82","author":"Banerjee","year":"2001","journal-title":"J. Gen. Virol."},{"issue":"1","key":"2026090313165305400_cit15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/viro.2000.0770","article-title":"Interaction of poliovirus-encoded 2C\/2BC polypeptides\nwith the 3\u2032 terminus negative-strand cloverleaf requires an\nintact stem-loop b","volume":"280","author":"Banerjee","year":"2001","journal-title":"Virology"},{"issue":"11","key":"2026090313165305400_cit16","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1128\/jvi.62.11.4016-4021.1988","article-title":"Isolation\nof poliovirus 2C mutants defective in viral RNA synthesis","volume":"62","author":"Li","year":"1988","journal-title":"J. Virol."},{"issue":"8","key":"2026090313165305400_cit17","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1099\/0022-1317-73-8-1977","article-title":"Analysis of\nthe functional significance of amino acid residues in the putative\nNTP-binding pattern of the poliovirus 2C protein","volume":"73","author":"Teterina","year":"1992","journal-title":"J. Gen. Virol."},{"issue":"5","key":"2026090313165305400_cit18","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/0022-2836(94)90060-4","article-title":"Genetic studies\non the poliovirus 2C protein, an NTPase. A plausible mechanism of\nguanidine effect on the 2C function and evidence for the importance\nof 2C oligomerization","volume":"236","author":"Tolskaya","year":"1994","journal-title":"J. Mol. Biol."},{"issue":"11","key":"2026090313165305400_cit19","doi-asserted-by":"crossref","first-page":"8482","DOI":"10.1128\/jvi.71.11.8482-8489.1997","article-title":"Synchronous replication of poliovirus RNA: initiation\nof negative-strand RNA synthesis requires the guanidine-inhibited\nactivity of protein 2C","volume":"71","author":"Barton","year":"1997","journal-title":"J. Virol."},{"issue":"11","key":"2026090313165305400_cit20","doi-asserted-by":"publisher","first-page":"5327","DOI":"10.1128\/JVI.02684-05","article-title":"Evidence for functional protein interactions required\nfor poliovirus RNA replication","volume":"80","author":"Teterina","year":"2006","journal-title":"J. Virol."},{"issue":"8","key":"2026090313165305400_cit21","doi-asserted-by":"publisher","first-page":"5888","DOI":"10.1074\/jbc.M611145200","article-title":"Reticulon 3 binds the 2C protein of enterovirus 71\nand is required for viral replication","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol.\nChem."},{"issue":"5","key":"2026090313165305400_cit22","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.4049\/jimmunol.1100285","article-title":"Enterovirus 71 2C protein\ninhibits TNF-alpha-mediated activation of NF-kappaB by suppressing\nIkappaB kinase beta phosphorylation","volume":"187","author":"Zheng","year":"2011","journal-title":"J. Immunol."},{"issue":"11","key":"2026090313165305400_cit23","doi-asserted-by":"crossref","first-page":"8759","DOI":"10.1128\/jvi.71.11.8759-8765.1997","article-title":"Poliovirus 2C region\nfunctions during encapsidation of viral RNA","volume":"71","author":"Vance","year":"1997","journal-title":"J. Virol."},{"issue":"1","key":"2026090313165305400_cit24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0166-3542(00)00119-4","article-title":"The antiviral compound\n5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic\ncleavages and the assembly of poliovirus in a cell-free system","volume":"48","author":"Verlinden","year":"2000","journal-title":"Antiviral Res."},{"issue":"8","key":"2026090313165305400_cit25","doi-asserted-by":"publisher","first-page":"e1001066","DOI":"10.1371\/journal.ppat.1001066","article-title":"Direct interaction\nbetween two viral proteins, the nonstructural protein 2C and the capsid\nprotein VP3, is required for enterovirus morphogenesis","volume":"6","author":"Liu","year":"2010","journal-title":"PLoS Pathog."},{"issue":"6","key":"2026090313165305400_cit26","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1099\/vir.0.062497-0","article-title":"A C-terminal, cysteine-rich site in poliovirus 2C(ATPase)\nis required for morphogenesis","volume":"95","author":"Wang","year":"2014","journal-title":"J. Gen. Virol."},{"issue":"8","key":"2026090313165305400_cit27","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.3390\/v7082832","article-title":"Replication and Inhibitors of Enteroviruses\nand Parechoviruses","volume":"7","author":"van der Linden","year":"2015","journal-title":"Viruses"},{"issue":"12","key":"2026090313165305400_cit28","doi-asserted-by":"crossref","first-page":"10536","DOI":"10.1128\/JVI.73.12.10536-10539.1999","article-title":"Dependence of echovirus 9 on the\nenterovirus RNA replication inhibitor 2-(alpha-Hydroxybenzyl)-benzimidazole\nmaps to nonstructural protein 2C","volume":"73","author":"Hadaschik","year":"1999","journal-title":"J. Virol."},{"issue":"10","key":"2026090313165305400_cit29","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.1128\/JVI.01338-07","article-title":"The thiazolobenzimidazole\nTBZE-029 inhibits enterovirus replication by targeting a short region\nimmediately downstream from motif C in the nonstructural protein 2C","volume":"82","author":"De Palma","year":"2008","journal-title":"J. Virol."},{"issue":"9","key":"2026090313165305400_cit30","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1128\/JVI.74.9.4146-4154.2000","article-title":"Mutations in the 2C region of poliovirus responsible\nfor altered sensitivity to benzimidazole derivatives","volume":"74","author":"Shimizu","year":"2000","journal-title":"J. Virol."},{"issue":"8","key":"2026090313165305400_cit31","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning:\nidentifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"10","key":"2026090313165305400_cit32","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.tim.2018.04.004","article-title":"Drug Repurposing\nfor Viral Infectious Diseases: How Far Are We?","volume":"26","author":"Mercorelli","year":"2018","journal-title":"Trends Microbiol."},{"issue":"9","key":"2026090313165305400_cit33","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.1128\/AAC.00983-12","article-title":"Fluoxetine Is a Potent\nInhibitor of Coxsackievirus Replication","volume":"56","author":"Zuo","year":"2012","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"4","key":"2026090313165305400_cit34","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1128\/AAC.02084-12","article-title":"Selective\nserotonin reuptake inhibitor fluoxetine inhibits replication of human\nenteroviruses B and D by targeting viral protein 2C","volume":"57","author":"Ulferts","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090313165305400_cit35","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1128\/AAC.02182-15","article-title":"Screening\nof a library of FDA-approved drugs identifies several enterovirus\nreplicaton inhibitors that target viral protein 2C","volume":"60","author":"Ulferts","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090313165305400_cit36","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.antiviral.2014.08.002","article-title":"Fluoxetine a novel anti-hepatitis\nC virus agent via ROS-, JNK-, and PPARbeta\/gamma-dependent pathways","volume":"110","author":"Young","year":"2014","journal-title":"Antiviral Res."},{"issue":"11","key":"2026090313165305400_cit37","doi-asserted-by":"publisher","first-page":"6709","DOI":"10.1128\/AAC.01367-16","article-title":"N-Desmethylclozapine, Fluoxetine,\nand Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle","volume":"60","author":"Medigeshi","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090313165305400_cit38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pediatrneurol.2016.06.014","article-title":"Treatment\nof Chronic Enterovirus Encephalitis With Fluoxetine in a Patient With\nX-Linked Agammaglobulinemia","volume":"64","author":"Gofshteyn","year":"2016","journal-title":"Pediatr Neurol"},{"issue":"4","key":"2026090313165305400_cit39","doi-asserted-by":"publisher","first-page":"e1602573","DOI":"10.1126\/sciadv.1602573","article-title":"Crystal structure of 2C helicase from enterovirus 71","volume":"3","author":"Guan","year":"2017","journal-title":"Sci. Adv."},{"issue":"1","key":"2026090313165305400_cit40","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1021\/jm00396a030","article-title":"Molecular\nstructure of fluoxetine hydrochloride, a highly selective serotonin-uptake\ninhibitor","volume":"31","author":"Robertson","year":"1988","journal-title":"J. Med. Chem."},{"issue":"3","key":"2026090313165305400_cit41","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1128\/AAC.02646-15","article-title":"Discovery of Structurally\nDiverse Small-Molecule Compounds with Broad Antiviral Activity against\nEnteroviruses","volume":"60","author":"Zuo","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090313165305400_cit42","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1111\/cmi.12425","article-title":"Cholesterol shuttling\nis important for RNA replication of coxsackievirus B3 and encephalomyocarditis\nvirus","volume":"17","author":"Albulescu","year":"2015","journal-title":"Cell. Microbiol."},{"issue":"4","key":"2026090313165305400_cit43","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.celrep.2014.12.054","article-title":"Itraconazole\ninhibits enterovirus replication by targeting the oxysterol-binding\nprotein","volume":"10","author":"Strating","year":"2015","journal-title":"Cell Rep."},{"key":"2026090313165305400_cit44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.antiviral.2014.03.013","article-title":"Assessment\nof Dengue virus helicase and methyltransferase as targets for fragment-based\ndrug discovery","volume":"106","author":"Coutard","year":"2014","journal-title":"Antiviral Res."},{"issue":"33","key":"2026090313165305400_cit45","doi-asserted-by":"publisher","first-page":"22012","DOI":"10.1074\/jbc.M109.031807","article-title":"Poliovirus 2C protein forms homo-oligomeric\nstructures required for ATPase activity","volume":"284","author":"Adams","year":"2009","journal-title":"J.\nBiol. Chem."},{"issue":"32","key":"2026090313165305400_cit46","doi-asserted-by":"publisher","first-page":"24347","DOI":"10.1074\/jbc.M110.129940","article-title":"Foot-and-mouth disease\nvirus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis\nmechanism","volume":"285","author":"Sweeney","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"10","key":"2026090313165305400_cit47","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1128\/AAC.01175-13","article-title":"A novel, broad-spectrum inhibitor of enterovirus replication\nthat targets host cell factor phosphatidylinositol 4-kinase IIIbeta","volume":"57","author":"van der Schaar","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"2026090313165305400_cit48","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1021\/ml400095m","article-title":"Identification of a series of compounds with potent antiviral activity\nfor the treatment of enterovirus infections","volume":"4","author":"MacLeod","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"2026090313165305400_cit49","unstructured":"Thibaut, H. J., Lee, C. K., Coutard, B., Van der Linden, L., Canard, B., De Palma, A. M., Van Kuppeveld, F., Jung, Y. 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