{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:02:29Z","timestamp":1768338149226,"version":"3.49.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["1KL2TR001444"],"award-info":[{"award-number":["1KL2TR001444"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI133394"],"award-info":[{"award-number":["R21AI133394"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2019,12,13]]},"DOI":"10.1021\/acsinfecdis.9b00227","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T11:13:48Z","timestamp":1570187628000},"page":"2029-2038","source":"Crossref","is-referenced-by-count":10,"title":["Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of <i>Naegleria fowleri<\/i> Sterol \u03948\u2212\u03947-Isomerase and Phenotypic Assays"],"prefix":"10.1021","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-2299","authenticated-orcid":true,"given":"Da","family":"Shi","sequence":"first","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti Kandhwal","family":"Chahal","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-Delhi Bypass Road, Hisar, Haryana 125001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Oto","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis-Felix","family":"Nothias","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan","family":"Debnath","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa M.","family":"Podust","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-2976","authenticated-orcid":true,"given":"Ruben","family":"Abagyan","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809991014"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.07.023"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.09.009"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.09.016"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1515\/ap-2017-0033"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.36.100182.000533"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.030635-0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2008.01.006"},{"key":"ref9\/cit9","unstructured":"Parasites \u2014 Naegleria fowleri \u2014 Primary Amebic Meningoencephalitis (PAM) \u2014 Amebic\nEncephalitis. Centers for Disease\nControl and Prevention; https:\/\/www.cdc.gov\/parasites\/naegleria\/index.html (accessed December 10th)."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2292"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ1021"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202113060607"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00286"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2174\/138920009788898019"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.501"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006104"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2005.00082.x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007245"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.3.4.573"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1987.tb11074.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111849"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.07.004"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/cr5003134"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nature17391"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400159-MCP200"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.07.001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.8072"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701079"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/bi961996m"},{"key":"ref30\/cit30","volume-title":"ICM Manual","author":"Abagyan R.","year":"2017"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx523"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10279-w"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(01)00117-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00643-12"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00414"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2018.03.010"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00434F"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01606.x"},{"issue":"4","key":"ref40\/cit40","first-page":"265","volume":"23","author":"Quispe M A.","year":"2006","journal-title":"Rev. Peru. Med. Exp. Salud Publica"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/cn100008c"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00029"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00250"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC04938A"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.06.037"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1604319"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1287"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1052"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540150503"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-012-9547-0"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14093"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92635-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2377"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3959"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3597"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T23:30:46Z","timestamp":1682206246000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.9b00227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,4]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12,13]]}},"alternative-id":["10.1021\/acsinfecdis.9b00227"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00227","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,4]]}}}