{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:58:48Z","timestamp":1768967928831,"version":"3.49.0"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI090048"],"award-info":[{"award-number":["AI090048"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College of Pharmacy, University of Kentucky"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2019,10,11]]},"DOI":"10.1021\/acsinfecdis.9b00228","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T18:48:42Z","timestamp":1566413322000},"page":"1772-1778","source":"Crossref","is-referenced-by-count":8,"title":["Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis"],"prefix":"10.1021","volume":"5","author":[{"given":"Keith D.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Punetha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-5555","authenticated-orcid":true,"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-4216","authenticated-orcid":true,"given":"Oleg V.","family":"Tsodikov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60410-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir889"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70139-0"},{"key":"ref4\/cit4","volume-title":"Global tuberculosis report 2018","author":"World Health Organization","year":"2018"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1086\/590009"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00208"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01611-09"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.267-274.2002"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmyco.2012.08.001"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt364"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01550-10"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907925106"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02191-12"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105379108"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00074"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00193"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01161"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00261"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00110"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100332"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020284"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bi00251a021"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(01)00051-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/B704785A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.11.021"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300359"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798316018210"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3767"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02116-16"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1295"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T20:29:47Z","timestamp":1681504187000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.9b00228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,11]]}},"alternative-id":["10.1021\/acsinfecdis.9b00228"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00228","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]}}}