{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:03:07Z","timestamp":1770415387249,"version":"3.49.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005712","name":"University of Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201700014I"],"award-info":[{"award-number":["HHSN272201700014I"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI126296"],"award-info":[{"award-number":["R21AI126296"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI133393"],"award-info":[{"award-number":["R21AI133393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32MH019934"],"award-info":[{"award-number":["T32MH019934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Support Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2019,10,11]]},"DOI":"10.1021\/acsinfecdis.9b00237","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T13:48:58Z","timestamp":1564408138000},"page":"1802-1812","source":"Crossref","is-referenced-by-count":36,"title":["The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni<\/i>"],"prefix":"10.1021","volume":"5","author":[{"given":"Betsaida","family":"Bibo-Verdugo","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehad","family":"Almaliti","sequence":"additional","affiliation":[{"name":"Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh P.","family":"Ta","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenze","family":"Jiang","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Wong","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Lietz","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"El-Sakkary","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-7024","authenticated-orcid":true,"given":"Vivian","family":"Hook","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy S.","family":"Salvesen","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-4458","authenticated-orcid":true,"given":"William H.","family":"Gerwick","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor R.","family":"Caffrey","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-0409","authenticated-orcid":true,"given":"Anthony J.","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2018.03.002"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1177\/1742395307084407"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.27"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328318978f"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(86)90184-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389899"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.2.199"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-56"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.09.025"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005840"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005919"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.271304"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040014"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3741"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(01)00056-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397863-9.00003-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14029"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.09.019"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06656"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.08.001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806109115"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00363"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820175116"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01161"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nature16936"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nature19339"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.01.002"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.08.002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207351"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184192"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001494"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00029-8"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4086"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209974"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2878"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087594"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303725200"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.25637"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.133"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13141-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10900"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80341-X"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200007"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00671"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3950-5"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.10.005"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nbt851"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.01.003"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073530"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2766"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.05.031"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001138"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.483"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90005-8"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040014"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000478"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.2307\/3280632"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005680"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18457-w"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200610873"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004356"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.468"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T20:29:56Z","timestamp":1681504196000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.9b00237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,29]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,11]]}},"alternative-id":["10.1021\/acsinfecdis.9b00237"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00237","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,29]]}}}