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The compounds were profiled for their physicochemical properties, transport across epithelial monolayers, cytotoxicity, and antibacterial activity as compared to common antibiotics. No cytotoxicity was reported in cell lines of fibroblast, hepatic, colorectal, or renal origin. C10 and C12 significantly increased the survival in a Galleria mellonella model infected with multi-drug-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococci (VRE) as compared to the untreated control group. Future studies are required to corroborate these findings in relevant animal model systems of infection.<\/jats:p>","DOI":"10.1021\/acsinfecdis.9b00378","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T10:57:42Z","timestamp":1591786662000},"page":"1674-1685","source":"Crossref","is-referenced-by-count":21,"title":["Antibacterial Anacardic Acid Derivatives"],"prefix":"10.1021","volume":"6","author":[{"given":"Marco","family":"Saedtler","sequence":"first","affiliation":[{"name":"Institute for Pharmacy and Food Chemistry , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Fo\u0308rtig","sequence":"additional","affiliation":[{"name":"Institute for Pharmacy and Food Chemistry , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Ohlsen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Infection Biology (IMIB) , Josef-Schneider-Stra\u00dfe 2 , ,","place":["Wu\u0308rzburg, Germany, 97080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Faber","sequence":"additional","affiliation":[{"name":"Institute for Molecular Infection Biology (IMIB) , Josef-Schneider-Stra\u00dfe 2 , ,","place":["Wu\u0308rzburg, Germany, 97080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Masota","sequence":"additional","affiliation":[{"name":"Institute for Pharmacy and Food Chemistry , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Kowalick","sequence":"additional","affiliation":[{"name":"Labor LS SE & Co. 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