{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:06:33Z","timestamp":1793131593757,"version":"4.5.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM128621"],"award-info":[{"award-number":["R35GM128621"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2020,2,14]]},"DOI":"10.1021\/acsinfecdis.9b00380","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T17:38:21Z","timestamp":1578505101000},"page":"159-167","source":"Crossref","is-referenced-by-count":30,"title":["Re-Engineering of Yohimbine\u2019s Biological Activity through Ring Distortion: Identification and Structure\u2013Activity Relationships of a New Class of Antiplasmodial Agents"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-1544","authenticated-orcid":true,"given":"Nicholas G.","family":"Paciaroni","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"David L.","family":"Perry","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Verrill M.","family":"Norwood","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-7181","authenticated-orcid":true,"given":"Claribel","family":"Murillo-Solano","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-4630","authenticated-orcid":true,"given":"Jennifer","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-8348","authenticated-orcid":true,"given":"Srinivasarao","family":"Tenneti","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-3119","authenticated-orcid":true,"given":"Debopam","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-2721","authenticated-orcid":true,"suffix":"III","given":"Robert W.","family":"Huigens","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization. (accessed September 30, 2019) World Malaria Report; https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/malaria."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/ph4050681"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.09.008"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2793"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3138"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1675-x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200905352"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3480"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3368"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01127.x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2201"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.04.603"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27908"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/457153a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1081"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.03.006"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007004"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja505861d"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ml200244k"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jm500994n"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nature19804"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1178"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1200"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1844"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0033-8"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1549"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308743"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201404765"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02333"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201604795"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02562"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0261-6"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201800768"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03248-2"},{"key":"ref37\/cit37","unstructured":"Huigens, R. W., III, and Paciaroni, N. G. (2017) Preparation of yohimbine analogues for the treatment of diseases. PCT Int. Appl. WO 2017190038 A1 20171102."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1803-1806.2004"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1807-1810.2004"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01607-06"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2016.02.004"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.02.002"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-2-r9"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jm1013693"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:50:37Z","timestamp":1681440637000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.9b00380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,14]]}},"alternative-id":["10.1021\/acsinfecdis.9b00380"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00380","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]}}}