{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:16:34Z","timestamp":1788423394741,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["23629"],"award-info":[{"award-number":["23629"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1017584"],"award-info":[{"award-number":["OPP1017584"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1134310"],"award-info":[{"award-number":["OPP1134310"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A series of benzimidazole\u2013benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness. The lead identified in this series, 8a\u00a0(AN8799), was found to have acceptable pharmacokinetic properties to enable evaluation in animal models of human filariasis. Compound 8a was effective in killing Brugia malayi, B.\u00a0pahangi, and Litomosoides sigmodontis worms present in Mongolian gerbils when dosed subcutaneously as a suspension at 100 mg\/kg\/day for 14 days but not when dosed orally at 100 mg\/kg\/day for 28 days. The measurement of plasma levels of 8a at the end of the dosing period and at the time of sacrifice revealed an interesting dependence of activity on the extended exposure for both 8a and the positive control, flubendazole.<\/jats:p>","DOI":"10.1021\/acsinfecdis.9b00396","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T08:18:16Z","timestamp":1577348296000},"page":"173-179","source":"Crossref","is-referenced-by-count":12,"title":["Macrofilaricidal Benzimidazole\u2013Benzoxaborole\nHybrids as an Approach to the Treatment of River Blindness: Part 1.\nAmide Linked Analogs"],"prefix":"10.1021","volume":"6","author":[{"given":"Tsutomu","family":"Akama","sequence":"first","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne R.","family":"Freund","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W.","family":"Berry","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Carter","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Easom","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Jarnagin","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Lunde","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Plattner","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rock","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianna","family":"Stefanakis","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of California San Francisco , , 1700 4th Street , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Bulman","sequence":"additional","affiliation":[{"name":"University of California San Francisco , , 1700 4th Street , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Chong","family":"Lim","sequence":"additional","affiliation":[{"name":"University of California San Francisco , , 1700 4th Street , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of California San Diego , , 9500 Gilman Drive , , ,","place":["La Jolla, California, United States, 92093-0657"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Tricoche","sequence":"additional","affiliation":[{"name":"New York Blood Center , , 310 E. 67th Street , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmoneim","family":"Mansour","sequence":"additional","affiliation":[{"name":"TRS Laboratories, Inc. , 295 Research Drive , , ,","place":["Athens, Georgia, United States, 30605"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utami","family":"DiCosty","sequence":"additional","affiliation":[{"name":"TRS Laboratories, Inc. , 295 Research Drive , , ,","place":["Athens, Georgia, United States, 30605"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McCall","sequence":"additional","affiliation":[{"name":"TRS Laboratories, Inc. , 295 Research Drive , , ,","place":["Athens, Georgia, United States, 30605"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Carson","sequence":"additional","affiliation":[{"name":"TRS Laboratories, Inc. , 295 Research Drive , , ,","place":["Athens, Georgia, United States, 30605"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"McCall","sequence":"additional","affiliation":[{"name":"TRS Laboratories, Inc. , 295 Research Drive , , ,","place":["Athens, Georgia, United States, 30605"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McKerrow","sequence":"additional","affiliation":[{"name":"University of California San Diego , , 9500 Gilman Drive , , ,","place":["La Jolla, California, United States, 92093-0657"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"Hu\u0308bner","sequence":"additional","affiliation":[{"name":"University Hospital Bonn , , Sigmund Freud Strasse 25 , ,","place":["Bonn, Germany, 53127"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Specht","sequence":"additional","affiliation":[{"name":"University Hospital Bonn , , Sigmund Freud Strasse 25 , ,","place":["Bonn, Germany, 53127"]},{"name":"Drugs for Neglected Diseases Initiative , 15 Chemin Louis-Dunant , ,","place":["Geneva, Switzerland, 1202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"University Hospital Bonn , , Sigmund Freud Strasse 25 , ,","place":["Bonn, Germany, 53127"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lustigman","sequence":"additional","affiliation":[{"name":"New York Blood Center , , 310 E. 67th Street , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-2982","authenticated-orcid":true,"given":"Judy A.","family":"Sakanari","sequence":"additional","affiliation":[{"name":"University of California San Francisco , , 1700 4th Street , , ,","place":["San Francisco, California, United States, 94158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-2862","authenticated-orcid":true,"given":"Robert T.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , , ,","place":["Palo Alto, California, United States, 94303"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"2026090304034595700_cit1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/B978-0-7020-5101-2.00055-8","article-title":"The Filariases","volume-title":"Manson\u2019s Tropical\nDiseases","author":"Simonsen","year":"2014","edition":"23"},{"issue":"12","key":"2026090304034595700_cit2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003328","article-title":"Global programme to eliminate lymphatic\nfilariasis: the processes underlying programme success","volume":"8","author":"Ichimori","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"Suppl\n1","key":"2026090304034595700_cit3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1179\/000349809X12502035776513","article-title":"The Global Programme\nto Eliminate Lymphatic Filariasis: health impact during its first\n8 years (2000\u20132007)","volume":"103","author":"Hooper","year":"2009","journal-title":"Ann. Trop. Med.\nParasitol."},{"key":"2026090304034595700_cit4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/cid\/civ882","article-title":"Efficacy, safety,\nand pharmacokinetics of coadministered diethylcarbamazine, albendazole,\nand ivermectin for treatment of Bancroftian filariasis","volume":"62","author":"Thomsen","year":"2016","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"2026090304034595700_cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005163","article-title":"Potential value\nof triple drug therapy with ivermectin, diethylcarbamazine, and albendazole\n(IDA) to accelerate elimination of lymphatic filariasis and onchocerciasis\nin Africa","volume":"11","author":"Fischer","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"11","key":"2026090304034595700_cit6","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.pt.2005.08.014","article-title":"Ivermectin\n20 years on: maturation of a wonder drug","volume":"21","author":"Geary","year":"2005","journal-title":"Trends\nParasitol."},{"issue":"4","key":"2026090304034595700_cit7","doi-asserted-by":"publisher","first-page":"640","DOI":"10.2165\/00003495-199142040-00007","article-title":"Ivermectin. A review\nof its antifilarial\nactivity, pharmacokinetic properties and clinical efficacy in onchocerciasis","volume":"42","author":"Goa","year":"1991","journal-title":"Drugs"},{"issue":"8","key":"2026090304034595700_cit8","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.trstmh.2007.03.018","article-title":"Randomized,\ncontrolled, double-blind\ntrial with ivermectin on Loa loa microfilaraemia: efficacy of a low\ndose (approximately 25 microg\/kg) versus current standard dose (150\nmicrog\/kg)","volume":"101","author":"Kamgno","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"9070","key":"2026090304034595700_cit9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis\nwith ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997","journal-title":"Lancet"},{"issue":"5","key":"2026090304034595700_cit10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1586\/eri.11.30","article-title":"Flubendazole: a candidate macrofilaricide\nfor lymphatic\nfilariasis and onchocerciasis field programs","volume":"9","author":"Mackenzie","year":"2011","journal-title":"Expert Rev. Anti-Infect. Ther."},{"issue":"8317","key":"2026090304034595700_cit11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0140-6736(83)92753-8","article-title":"Comparison\nof flubendazole and diethylcarbamazine in treatment of onchocerciasis","volume":"321","author":"Dominguez-Vazquez","year":"1983","journal-title":"Lancet"},{"issue":"6","key":"2026090304034595700_cit12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.2307\/3280393","article-title":"Chemoprophylactic activity\nof flubendazole against\nadult Brugia pahangi transplanted into the peritoneal cavity of jirds","volume":"66","author":"Denham","year":"1980","journal-title":"J. Parasitol."},{"issue":"6","key":"2026090304034595700_cit13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0035-9203(79)90018-X","article-title":"The anthelmintic\neffects of flubendazole on Brugia pahangi","volume":"73","author":"Denham","year":"1979","journal-title":"Trans.\nR. Soc. Trop. Med. Hyg."},{"issue":"3","key":"2026090304034595700_cit14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3109\/03602539308993977","article-title":"Clinical pharmacokinetics\nand metabolism of benzimidazole\nanthelmintics in ruminants","volume":"25","author":"Lanusse","year":"1993","journal-title":"Drug Metab. Rev."},{"key":"2026090304034595700_cit15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1746-6148-8-71","article-title":"Exploring\nflubendazole formulations for use in sheep. Pharmacokinetic evaluation\nof a cyclodextrin-based solution","volume":"8","author":"Ceballos","year":"2012","journal-title":"BMC Vet. Res."},{"key":"2026090304034595700_cit16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.reprotox.2012.12.004","article-title":"Effects of\nthe benzimidazole anthelmintic drug flubendazole on rat embryos in\nvitro","volume":"36","author":"Longo","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"2026090304034595700_cit17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.reprotox.2014.06.009","article-title":"In vivo preliminary\ninvestigations of the effects of the benzimidazole anthelmintic drug\nflubendazole on rat embryos and fetuses","volume":"49","author":"Longo","year":"2014","journal-title":"Reprod.\nToxicol."},{"key":"2026090304034595700_cit18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/mutage\/gev070","article-title":"Genotoxicity\nof flubendazole and the impact of a new formulation on in vivo aneugenicity","volume":"31","author":"Tweats","year":"2016","journal-title":"Mutagenesis"},{"issue":"5","key":"2026090304034595700_cit19","doi-asserted-by":"publisher","first-page":"e02419-17","DOI":"10.1128\/AAC.02419-17","article-title":"Topical\nTreatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead\nOptimization of Benzoxaboroles","volume":"62","author":"Van Bocxlaer","year":"2018","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"1","key":"2026090304034595700_cit20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bmcl.2017.11.028","article-title":"Identification of a 4-fluorobenzyl\nl-valinate amide benzoxaborole (AN11736) as a potential development\ncandidate for the treatment of Animal African Trypanosomiasis (AAT)","volume":"28","author":"Akama","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"13","key":"2026090304034595700_cit21","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.1021\/acs.jmedchem.7b00621","article-title":"Benzoxaborole\nAntimalarial Agents.\nPart 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles\nand Identification of a Preclinical Candidate","volume":"60","author":"Zhang","year":"2017","journal-title":"J. Med. Chem."},{"issue":"23","key":"2026090304034595700_cit22","doi-asserted-by":"publisher","first-page":"5589","DOI":"10.1016\/j.bmcl.2015.10.044","article-title":"Discovery of an orally\nbioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal\nectoparasiticide","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"2026090304034595700_cit23","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1021\/cr500642d","article-title":"Recent Developments in the Chemistry\nand Biological Applications of Benzoxaboroles","volume":"115","author":"Adamczyk-Wozniak","year":"2015","journal-title":"Chem. Rev."},{"issue":"6","key":"2026090304034595700_cit24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1097\/QCO.0b013e32834c630e","article-title":"Boron-based drugs as antiprotozoals","volume":"24","author":"Jacobs","year":"2011","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"6","key":"2026090304034595700_cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001151","article-title":"SCYX-7158,\nan orally-active benzoxaborole\nfor the treatment of stage 2 human African trypanosomiasis","volume":"5","author":"Jacobs","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"10","key":"2026090304034595700_cit26","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1128\/AAC.00498-10","article-title":"Discovery\nof novel orally bioavailable oxaborole 6-carboxamides\nthat demonstrate cure in a murine model of late-stage central nervous\nsystem african trypanosomiasis","volume":"54","author":"Nare","year":"2010","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"6","key":"2026090304034595700_cit27","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1021\/jp9086283","article-title":"Influence\nof the substituents on\nthe structure and properties of benzoxaboroles","volume":"114","author":"Adamczyk-Wozniak","year":"2010","journal-title":"J. Phys. Chem. A"},{"issue":"10","key":"2026090304034595700_cit28","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1002\/jps.20901","article-title":"In Vitro\npenetration\nof a novel oxaborole antifungal (AN2690) into the human nail plate","volume":"96","author":"Hui","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"15","key":"2026090304034595700_cit29","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1021\/jm0603724","article-title":"Discovery of a new boron-containing\nantifungal agent,\n5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the\npotential treatment of onychomycosis","volume":"49","author":"Baker","year":"2006","journal-title":"J. Med.\nChem."},{"issue":"23","key":"2026090304034595700_cit30","doi-asserted-by":"publisher","first-page":"5963","DOI":"10.1016\/j.bmcl.2006.08.130","article-title":"Identification of\na novel boron-containing antibacterial agent (AN0128) with anti-inflammatory\nactivity, for the potential treatment of cutaneous diseases","volume":"16","author":"Baker","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"2026090304034595700_cit31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1021\/jm00081a016","article-title":"Synthesis\nand biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates\nand related derivatives: a new class of potential antineoplastic and\nantifilarial agents","volume":"35","author":"Ram","year":"1992","journal-title":"J. Med. Chem."},{"issue":"24","key":"2026090304034595700_cit33","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1016\/j.bmcl.2010.10.071","article-title":"Synthesis\nand biological evaluations of P4-benzoxaborole-substituted macrocyclic\ninhibitors of HCV NS3 protease","volume":"20","author":"Ding","year":"2010","journal-title":"Bioorg. Med.\nChem. Lett."},{"issue":"8","key":"2026090304034595700_cit34","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1073\/pnas.0915125107","article-title":"Repositioning\nof an existing drug for the neglected tropical disease Onchocerciasis","volume":"107","author":"Gloeckner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"2026090304034595700_cit35","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1021\/acsinfecdis.5b00017","article-title":"Onchocerca volvulus\nMolting Inhibitors Identified through\nScaffold Hopping","volume":"1","author":"Gooyit","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"2026090304034595700_cit36","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1385\/1-59259-811-0:301","article-title":"Analysis of\ncell cycle by flow cytometry","volume":"281","author":"Pozarowski","year":"2004","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"2026090304034595700_cit37","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0014-5793(97)01442-7","article-title":"Transport of glutathione\nprostaglandin\nA conjugates by the multidrug resistance protein 1","volume":"419","author":"Evers","year":"1997","journal-title":"FEBS Lett."},{"issue":"1","key":"2026090304034595700_cit38","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1021\/js9803205","article-title":"MDCK (Madin-Darby\ncanine kidney)\ncells: A tool for membrane permeability screening","volume":"88","author":"Irvine","year":"1999","journal-title":"J. Pharm. Sci."},{"issue":"6","key":"2026090304034595700_cit39","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1023\/A:1016140429238","article-title":"Are MDCK\ncells transfected with the\nhuman MDR1 gene a good model of the human intestinal mucosa?","volume":"19","author":"Tang","year":"2002","journal-title":"Pharm. Res."},{"issue":"1","key":"2026090304034595700_cit40","first-page":"7","article-title":"Flow cytometric assay of modulation of P-glycoprotein\nfunction in whole blood by the multidrug resistance inhibitor GG918","volume":"2","author":"Witherspoon","year":"1996","journal-title":"Clin. Cancer Res."},{"issue":"19","key":"2026090304034595700_cit41","first-page":"4595","article-title":"In vitro and\nin vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide\nderivative","volume":"53","author":"Hyafil","year":"1993","journal-title":"Cancer Res."},{"issue":"6","key":"2026090304034595700_cit42","doi-asserted-by":"publisher","first-page":"791","DOI":"10.4269\/ajtmh.1994.51.791","article-title":"Filariasis testing\nin a jird model: new drug leads\nfrom some old standbys","volume":"51","author":"Kinnamon","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2026090304034595700_cit43","first-page":"180","article-title":"The pharmacokinetics\nof mebendazole and flubendazole in animals and man","volume":"256","author":"Michiels","year":"1982","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"1","key":"2026090304034595700_cit44","doi-asserted-by":"publisher","first-page":"e0006436","DOI":"10.1371\/journal.pntd.0006436","article-title":"Flubendazole as a macrofilaricide:\nHistory and background","volume":"13","author":"Geary","year":"2019","journal-title":"PLoS Neglected Trop.\nDis."},{"issue":"2","key":"2026090304034595700_cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003534","article-title":"Repurposing auranofin as a lead candidate for treatment\nof lymphatic filariasis and onchocerciasis","volume":"9","author":"Bulman","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"2026090304034595700_cit46","doi-asserted-by":"publisher","first-page":"e0006320","DOI":"10.1371\/journal.pntd.0006320","article-title":"Macrofilaricidal efficacy of single and repeated oral\nand subcutaneous doses of flubendazole in Litomosoides sigmodontis\ninfected jirds","volume":"13","author":"Hu\u0308bner","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"3","key":"2026090304034595700_cit47","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1128\/CMR.00002-13","article-title":"A comprehensive, model-based\nreview of vaccine and repeat infection trials for filariasis","volume":"26","author":"Morris","year":"2013","journal-title":"Clin Microbiol Rev."},{"issue":"1","key":"2026090304034595700_cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001494","article-title":"WormAssay:\na novel computer application for whole-plate motion-based screening\nof macroscopic parasites","volume":"6","author":"Marcellino","year":"2012","journal-title":"PLoS Neglected Trop.\nDis."},{"issue":"21","key":"2026090304034595700_cit49","doi-asserted-by":"publisher","first-page":"6540","DOI":"10.1016\/j.bmcl.2012.08.059","article-title":"How hydrogen bonds\nimpact P-glycoprotein\ntransport and permeability","volume":"22","author":"Desai","year":"2012","journal-title":"Bioorg. Med. Chem.\nLett."},{"issue":"1","key":"2026090304034595700_cit50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/mp0500871","article-title":"P-glycoprotein\nrecognition of substrates and circumvention through rational drug\ndesign","volume":"3","author":"Raub","year":"2006","journal-title":"Mol. Pharmaceutics"},{"issue":"14","key":"2026090304034595700_cit51","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","article-title":"Fluorine\nand Fluorinated Motifs in the Design and Application of Bioisosteres\nfor Drug Design","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. Med. Chem."}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.9b00396","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/2\/173\/67183397\/acsinfecdis.9b00396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article-pdf\/6\/2\/173\/67183397\/acsinfecdis.9b00396.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:03:54Z","timestamp":1788422634000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aidcbc\/article\/6\/2\/173\/618198\/Macrofilaricidal-Benzimidazole-Benzoxaborole"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,26]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,26]]},"published-print":{"date-parts":[[2020,2,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00396","relation":{},"ISSN":["2373-8227"],"issn-type":[{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,26]]}}}