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The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. Compound 21was effective in killing worms implanted in Mongolian gerbils when dosed orally as a suspension at 100 mg\/kg\/day for 14 days but not when dosed orally at 100 mg\/kg\/day for 7 days.<\/jats:p>","DOI":"10.1021\/acsinfecdis.9b00397","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T08:15:11Z","timestamp":1577348111000},"page":"180-185","source":"Crossref","is-referenced-by-count":13,"title":["Macrofilaricidal Benzimidazole\u2013Benzoxaborole\nHybrids as an Approach to the Treatment of River Blindness: Part 2.\nKetone Linked Analogs"],"prefix":"10.1021","volume":"6","author":[{"given":"David S.","family":"Carter","sequence":"first","affiliation":[{"name":"Anacor Pharmaceuticals, Inc. , 1020 E. 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