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Unsurprisingly, its prognosis is quite poor; early detection methods and effective low-toxicity treatments are urgently needed. To achieve these goals, we designed a multifunctional, U.S. Food and Drug Administration-approved Prussian blue (PB) nanoparticle (NP) with a porous metal organic frame loaded with sorafenib (SF), conjugated with HCC-specific targeting peptide SP94 and the near-infrared dye cyanine (Cy)\u00ad5.5. These NPs are amenable to multimodal imaging for dynamic monitoring of their biodistribution and tumor-targeting effects. The SP94-PB-SF-Cy5.5 NPs achieved targeted delivery and controlled SF release and exhibited good photothermal effects. In this strategy, photothermal therapy and SF treatment complement each other, reducing the side effects of SF and achieving a therapeutic effect without local tumor recurrence. In addition, the catalase-like ability of the NPs alleviates tumor hypoxia, and their photothermal effects induce immunogenic cell death, leading to the release of tumor-associated antigens. These effects combine to trigger an antitumor immune response; the NPs also displayed promising inhibitory effects on tumor metastasis and recurrence and produced an abscopal effect and long-term immunological memory when combined with antiprogrammed death-ligand 1 (PD-L1) immunotherapy. These safe, multifunctional NPs represent a valuable treatment option for HCC. In addition, this next-generation treatment model may provide some ideas for the management of HCC and other cancers.<\/jats:p>","DOI":"10.1021\/acsnano.0c01453","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T11:40:33Z","timestamp":1599738033000},"page":"12679-12696","source":"Crossref","is-referenced-by-count":163,"title":["A\nHepatocellular Carcinoma Targeting Nanostrategy\nwith Hypoxia-Ameliorating and Photothermal Abilities that, Combined\nwith Immunotherapy, Inhibits Metastasis and Recurrence"],"prefix":"10.1021","volume":"14","author":[{"given":"Tianjun","family":"Zhou","sequence":"first","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, China, 510280"]},{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]},{"name":"Provincial Clinical and Engineering Center of Digital Medicine , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, China, 510280"]},{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]},{"name":"Provincial Clinical and Engineering Center of Digital Medicine , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"Hu","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, China, 510280"]},{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]},{"name":"Provincial Clinical and Engineering Center of Digital Medicine , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushen","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention , , , ,","place":["Beijing, China, 100013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihua","family":"Fang","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, China, 510280"]},{"name":"Provincial Clinical and Engineering Center of Digital Medicine , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-0432","authenticated-orcid":true,"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Automation, Chinese Academy of Sciences , , , ,","place":["Beijing, China, 100190"]},{"name":"Beihang University , , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2026081718255450500_cit1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer Statistics\nin China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"Ca-Cancer J. 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