{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:39:43Z","timestamp":1776793183059,"version":"3.51.2"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16cm0106202h0001"],"award-info":[{"award-number":["16cm0106202h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009033","name":"Center of Innovation Program","doi-asserted-by":"publisher","award":["JPMJCE1305"],"award-info":[{"award-number":["JPMJCE1305"]}],"id":[{"id":"10.13039\/501100009033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H04524"],"award-info":[{"award-number":["20H04524"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H04170"],"award-info":[{"award-number":["JP18H04170"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2020,8,25]]},"DOI":"10.1021\/acsnano.0c03386","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T08:30:05Z","timestamp":1596702605000},"page":"10127-10140","source":"Crossref","is-referenced-by-count":69,"title":["Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma"],"prefix":"10.1021","volume":"14","author":[{"given":"Hiroaki","family":"Kinoh","sequence":"first","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-7408","authenticated-orcid":true,"given":"Sabina","family":"Quader","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"},{"name":"Department of Otolaryngology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Liu","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Maity","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamasoba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-2631","authenticated-orcid":true,"given":"Horacio","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-413X","authenticated-orcid":true,"given":"Kazunori","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi,\rKawasaki-ku, Kawasaki 210-0821, Japan"},{"name":"Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0177-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21586"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4971"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.03.003"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nature05236"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq082"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0007-y"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3626"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.10.012"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nm1523"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2942"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0520-4"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0308-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2015.08.004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.6.1029"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1637188"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-13"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/BF01842886"},{"key":"ref20\/cit20","first-page":"237","volume":"12","author":"Sakai N.","year":"1984","journal-title":"No Shinkei Geka"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200202000-00013"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.2027"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200250653"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12153"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0422-z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.7150\/jca.4149"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0151"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0349-y"},{"key":"ref29\/cit29","first-page":"1309","volume":"22","author":"Martinez-Murillo R.","year":"2007","journal-title":"Histol Histopathol."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07851-z"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.4161\/hv.25561"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-015-0060-6"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0345-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/nm1517"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.955691"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3141"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18540-2"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1846"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00199"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199426060-00002"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2017.09.006"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-014-1651-7"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nri3818"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.006"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85841"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04023-x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01503"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2605"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020563"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.106"},{"key":"ref52\/cit52","first-page":"5095","volume":"50","author":"Tjuljandin S. A.","year":"1990","journal-title":"Cancer Res."},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01739"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091318"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0283"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3773"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6012"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq172"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1459"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.04.033"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0753"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100269"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.003"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.02.002"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28163"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065145"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14116"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.0c03386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:34:51Z","timestamp":1681691691000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.0c03386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,25]]}},"alternative-id":["10.1021\/acsnano.0c03386"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.0c03386","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}