{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:10:21Z","timestamp":1791605421816,"version":"4.3.4"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"College of Engineering and Applied Science, University of Colorado Boulder"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While tattooable nanotechnology for in-skin sensing and communication has been a popular concept in science fiction since the 1990s, the first tattooable intradermal nanosensors have only emerged in the past few years, and none have been demonstrated in human skin. We developed a photochromic tattoo that serves as an intradermal ultraviolet (UV) radiometer that provides naked-eye feedback about UV exposure in real time. These small tattoos, or \u201csolar freckles\u201d, comprise dermally implanted colorimetric UV sensors in the form of nanoencapsulated leuco dyes that become more blue in color with increasing UV irradiance. We demonstrate the tattoos\u2019 functionality for both quantitative and naked-eye UV sensing in porcine skin ex vivo, as well as in human skin in vivo. Solar freckles offer an alternative and complementary approach to self-monitoring UV exposure for the sake of skin cancer prevention. Activated solar freckles provide a visual reminder to protect the skin, and their color disappears rapidly upon removal of UV exposure or application of topical sunscreen. The sensors are implanted in a minimally invasive procedure that lasts only a few seconds, yet remain functional for months to years. These semipermanent tattoos provide an early proof-of-concept for long-term intradermal sensing nanomaterials that provide users with biomedically relevant information in the form of an observable color change.<\/jats:p>","DOI":"10.1021\/acsnano.0c05723","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T20:41:52Z","timestamp":1600807312000},"page":"13619-13628","source":"Crossref","is-referenced-by-count":37,"title":["Solar\nFreckles: Long-Term Photochromic Tattoos for\nIntradermal Ultraviolet Radiometry"],"prefix":"10.1021","volume":"14","author":[{"given":"Jesse\nL.","family":"Butterfield","sequence":"first","affiliation":[{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Keyser","sequence":"additional","affiliation":[{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-7917","authenticated-orcid":true,"given":"Karan V.","family":"Dikshit","sequence":"additional","affiliation":[{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejin","family":"Kwon","sequence":"additional","affiliation":[{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maranke I.","family":"Koster","sequence":"additional","affiliation":[{"name":"University of Colorado\ue5f8Denver , , Anschutz Medical Campus , , ,","place":["Denver, Colorado, United States, 80217"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-2725","authenticated-orcid":true,"given":"Carson J.","family":"Bruns","sequence":"additional","affiliation":[{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]},{"name":"University of Colorado\ue5f8Boulder , , , ,","place":["Boulder, Colorado, United States, 80309"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"2026081719081209300_cit1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.amepre.2014.08.036","article-title":"Prevalence and Costs\nof Skin Cancer Treatment in the U.S., 2002\u20132006 and 2007\u20132011","volume":"48","author":"Guy","year":"2015","journal-title":"Am. 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Dermatol."},{"key":"2026081719081209300_cit7","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1001\/jama.2019.5586","article-title":"Effect\nof Sunscreen Application under\nMaximal Use Conditions on Plasma Concentration of Sunscreen Active\nIngredients: A Randomized Clinical Trial","volume":"321","author":"Matta","year":"2019","journal-title":"JAMA"},{"key":"2026081719081209300_cit8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/ics.12443","article-title":"Understanding\nSunscreen SPF Performance Using Cross-Polarized UVA Reflectance Photography","volume":"40","author":"Crowther","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"2026081719081209300_cit9","unstructured":"Ross, J. S.; Morefield, E. M.\n          Sunscreen with\nDisappearing Color Indicator. 2001; US6290936B1, US Patent Office."},{"key":"2026081719081209300_cit10","unstructured":"Alvarez, C. E. O.; Tibbits, S. J. E.; Coelho, M. 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