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The connections between microbiota and human diseases offer numerous opportunities in medicine, most of which have limited or no therapeutic solutions available. In light of this paradigm-setting trend in science, this review aims to provide a comprehensive and timely summary of the mechanistic pathways governing the gut microbiota and their implications for nanomedicines targeting cancer and neurodegenerative diseases. Specifically, we discuss in parallel the beneficial and pathogenic relationship of the gut microbiota along the gut\u2013brain and gut\u2013cancer axes, elaborate on the impact of dysbiosis and the gastrointestinal corona on the efficacy of nanomedicines, and highlight a molecular mimicry that manipulates the universal cross-\u03b2 backbone of bacterial amyloid to accelerate neurological disorders. This review further offers a forward-looking section on the rational design of cancer and dementia nanomedicines exploiting the gut\u2013brain and gut\u2013cancer axes.<\/jats:p>","DOI":"10.1021\/acsnano.0c07258","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T21:38:46Z","timestamp":1604353126000},"page":"14391-14416","source":"Crossref","is-referenced-by-count":47,"title":["Implications\nof the Human Gut\u2013Brain and Gut\u2013Cancer\nAxes for Future Nanomedicine"],"prefix":"10.1021","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-5614","authenticated-orcid":true,"given":"Ibrahim","family":"Javed","sequence":"first","affiliation":[{"name":"University of Queensland , , , ,","place":["Brisbane, Queensland, Australia, 4072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Cui","sequence":"additional","affiliation":[{"name":"National Center for Nanoscience and Technology of China , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Nanoscience and Technology of China , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-521X","authenticated-orcid":true,"given":"Monika","family":"Mortimer","sequence":"additional","affiliation":[{"name":"China Jiliang University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Andrikopoulos","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Melbourne, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Li","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Melbourne, Victoria, Australia, 3052"]},{"name":"Fudan University , , 111 Yixueyuan Rd , Xuhui District, ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-4986","authenticated-orcid":true,"given":"Thomas P.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Queensland , , , ,","place":["Brisbane, Queensland, Australia, 4072"]},{"name":"Monash University , , , ,","place":["Melbourne, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-9360","authenticated-orcid":true,"given":"Yuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Center for Nanoscience and Technology of China , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-0859","authenticated-orcid":true,"given":"Pu Chun","family":"Ke","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Melbourne, Victoria, Australia, 3052"]},{"name":"Fudan University , , 111 Yixueyuan Rd , Xuhui District, ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-0315","authenticated-orcid":true,"given":"Chunying","family":"Chen","sequence":"additional","affiliation":[{"name":"National Center for Nanoscience and Technology of China , , ,","place":["Beijing, China, 100190"]},{"name":"GBA Research Innovation Institute for Nanotechnology , ,","place":["Guangdong, China, 510700"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"2026081720235427300_cit1","doi-asserted-by":"publisher","first-page":"15490","DOI":"10.1523\/JNEUROSCI.3299-14.2014","article-title":"Gut Microbes\nand the Brain: Paradigm Shift in Neuroscience","volume":"34","author":"Mayer","year":"2014","journal-title":"J. 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