{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:50:53Z","timestamp":1794642653737,"version":"4.9.1"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L021978\/2"],"award-info":[{"award-number":["EP\/L021978\/2"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016128","name":"Henry Royce Institute","doi-asserted-by":"publisher","award":["EP\/R00661X\/1, EP\/S019367\/1, EP\/P025021\/1 and EP\/P0"],"award-info":[{"award-number":["EP\/R00661X\/1, EP\/S019367\/1, EP\/P025021\/1 and EP\/P0"]}],"id":[{"id":"10.13039\/100016128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R015651\/1"],"award-info":[{"award-number":["MR\/R015651\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","award":["AOCMF-17-19M"],"award-info":[{"award-number":["AOCMF-17-19M"]}],"id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["STROFUNSCAFF"],"award-info":[{"award-number":["STROFUNSCAFF"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2021,7,27]]},"DOI":"10.1021\/acsnano.0c09814","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:14:25Z","timestamp":1624878865000},"page":"11202-11217","source":"Crossref","is-referenced-by-count":80,"title":["<i>De Novo<\/i>\n                    Design of Functional Coassembling Organic\u2013Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-9205","authenticated-orcid":true,"given":"Babatunde O.","family":"Okesola","sequence":"first","affiliation":[{"name":"Institute of Bioengineering, Queen Mary University of London, London E1 4NS, U.K."},{"name":"School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karen","family":"Mendoza-Martinez","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Queen Mary University of London, London E1 4NS, U.K."},{"name":"School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Cidonio","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, U.K."},{"name":"Center for Life Nano- & Neuro- Science (CL2NS), Fondazione Istituto Italiano di Tecnologia, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-0995","authenticated-orcid":true,"given":"Burak","family":"Derkus","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Queen Mary University of London, London E1 4NS, U.K."},{"name":"School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K."},{"name":"Department of Chemistry, Faculty of Science, Ankara University, 06560 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delali K.","family":"Boccorh","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow G1 1RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Osuna de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Centre for Oral, Clinical, and Translational Sciences, Faculty of Dentistry, Oral, and Craniofacial Sciences, King\u2019s College London, London SE1 1UL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K."},{"name":"Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-0598","authenticated-orcid":true,"given":"Jonathan I.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-7566","authenticated-orcid":true,"given":"Alastair W.","family":"Wark","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow G1 1RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-2819","authenticated-orcid":true,"given":"Dafna","family":"Knani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Engineering, ORT Braude College, Karmiel 2161002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3176-1350","authenticated-orcid":true,"given":"Dave J.","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Chemistry, College of Science and Engineering, University of Glasgow, Glasgow G12 8QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-6726","authenticated-orcid":true,"given":"Richard O. C.","family":"Oreffo","sequence":"additional","affiliation":[{"name":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Mata","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Queen Mary University of London, London E1 4NS, U.K."},{"name":"School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K."},{"name":"School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K."},{"name":"Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K."},{"name":"Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham NG7 2RD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4089"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800178"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201200300"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ma10020119"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020902)41:17<3167::AID-ANIE3167>3.0.CO;2-R"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/ma12040581"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC02914A"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507684"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/nn507488s"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04319-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06492"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201906205"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2020.131344"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/pj.2012.171"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00179"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3103"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2496"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200400039"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001142107"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00113"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61530-0"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/la0487747"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200402086"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/cm061468p"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15317"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24659-7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.8b11515"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200600716"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.5b01947"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601144"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00121A"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900332"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.12.024"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0281"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.08.025"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2016.1182914"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02434"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b00891"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA03040F"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.11.024"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.023"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154586"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2349"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703716"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01796H"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.9b01882"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics4010020"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nature08693"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-61779-388-2_3","volume-title":"Nanotechnology in Regenerative Medicine: Methods and Protocols","author":"Mata A.","year":"2012"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00923"},{"key":"ref51\/cit51","unstructured":"BIOVIA\nMaterials Studio - An Integrated, Multi-Scale Modeling Environment.\nAccessed 2020-01-25. www.3ds.com\/products-services\/biovia\/products\/molecular-modeling-simulation\/biovia-materials-studio\/."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7295"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.004"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07723"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3015"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11156-6"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/am4044823"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2490"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20001002)39:19<3392::AID-ANIE3392>3.0.CO;2-M"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6760"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07477"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b01697"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109243109"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.026"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/am504566v"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/cm960425d"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN00342C"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02932-7"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420942734"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.0c09814","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.0c09814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:59:13Z","timestamp":1682582353000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.0c09814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,27]]}},"alternative-id":["10.1021\/acsnano.0c09814"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.0c09814","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsnano.0c09814.s001","asserted-by":"subject"}]},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]}}}