{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:13:01Z","timestamp":1790809981019,"version":"4.1.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Fondation ARC Association pour la Recherche sur le Cancer","award":["20190508933"],"award-info":[{"award-number":["20190508933"]}]},{"name":"ITMO Cancer","award":["ITMO-Inserm Plan Cancer 2014-2019 (N? PC201620)"],"award-info":[{"award-number":["ITMO-Inserm Plan Cancer 2014-2019 (N? PC201620)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The dissemination of tumor metastasis in the peritoneal cavity, also called peritoneal metastasis (PM) or carcinomatosis, represents a late stage of gastrointestinal and gynecological cancer with very poor prognosis, even when cytoreductive surgery is effective, due to residual microscopic disease. Photodynamic therapy (PDT) in the management of peritoneal metastasis has been clinically limited by the low tumor selectivity of photosensitizers (PS) and important adverse effects. Here, we propose extracellular nanovesicles (EVs) derived from mesenchymal stem\/stromal cells (MSCs) as the fourth generation of immune active PS vectors that are able to target peritoneal metastasis with superior selectivity, potentiate PDT cytotoxicity at the tumor site without affecting healthy tissues, modulate the tumor microenvironment of immunocompetent colorectal and ovarian carcinomatosis models, and promote an antitumor immune response. A pioneering strategy was developed for high yield, large-scale production of MSC-EVs encapsulating the drug meta(tetrahydroxyphenyl)\u00adchlorin (mTHPC) (EVs-mTHPC) that is compatible with requirements of clinical translation and also preserves the topology and integrity of naturally produced EVs. Intraperitoneal injection of EVs-mTHPC showed an impressive enhancement of tumoral selectivity in comparison to the free drug and to the liposomal formulation Foslip (mean ratio of PS in tumors\/organs of 40 for EVs-mTHPC versus 1.5 for the free PS and 5.5 for Foslip). PDT mediated by EVs-mTHPC permitted an important tumoral necrosis (55% of necrotic tumoral nodules versus 18% for Foslip (p &amp;lt; 0.0001)) and promoted antitumor immune cell infiltration, mainly proinflammatory M1-like CD80+ and CD8+ T cell effector. Intratumor proliferation was significantly decreased after PDT with EVs-mTHPC. Overall EVs vectorization of mTHPC afforded important tumoral selectivity while overcoming the PDT toxicity of the free drug and prolonged mice survival in the colorectal carcinomatosis model. MSC-EVs produced by our scalable manufacturing method appears like the clinically relevant fourth-generation PDT vehicle to overcome current limitations of PDT in the treatment of peritoneal metastasis and promote a hot tumor immune environment in PM.<\/jats:p>","DOI":"10.1021\/acsnano.0c09938","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:26:38Z","timestamp":1611361598000},"page":"3251-3263","source":"Crossref","is-referenced-by-count":69,"title":["Immune\nReprogramming Precision Photodynamic Therapy\nof Peritoneal Metastasis by Scalable Stem-Cell-Derived Extracellular\nVesicles"],"prefix":"10.1021","volume":"15","author":[{"given":"Amandine","family":"Pinto","sequence":"first","affiliation":[{"name":"Universite\u0301 de Paris , , ,","place":["Paris, France, F-75010"]},{"name":"Ho\u0302pital Lariboisie\u0300re AP-HP , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Marangon","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Me\u0301reaux","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , ,","place":["Paris, France, F-75010"]},{"name":"Ho\u0302pital Lariboisie\u0300re AP-HP , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Nicola\u0301s-Boluda","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gre\u0301gory","family":"Lavieu","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-9627","authenticated-orcid":true,"given":"Claire","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Sarda-Mantel","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris, Ho\u0302pital Lariboisie\u0300re AP-HP , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda K. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pocard","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , ,","place":["Paris, France, F-75010"]},{"name":"Ho\u0302pital Lariboisie\u0300re AP-HP , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-3597","authenticated-orcid":true,"given":"Florence","family":"Gazeau","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , Cedex 13,","place":["Paris, France, 75205"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"2026081810213025000_cit1","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/S1470-2045(16)30500-9","article-title":"Prognosis\nof Patients with Peritoneal Metastatic Colorectal Cancer Given Systemic\nTherapy: An Analysis of Individual Patient Data from Prospective Randomised\nTrials from the Analysis and Research in Cancers of the Digestive\nSystem (ARCAD) Database","volume":"17","author":"Franko","year":"2016","journal-title":"Lancet Oncol."},{"key":"2026081810213025000_cit2","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic\nIntraperitoneal Chemotherapy in Ovarian Cancer","volume":"378","author":"van\nDriel","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2026081810213025000_cit3","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jviscsurg.2019.08.002","article-title":"Management of Colorectal Peritoneal\nMetastases: Expert Opinion","volume":"156","author":"Abboud","year":"2019","journal-title":"J. Visc. Surg."},{"key":"2026081810213025000_cit4","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.ejso.2018.08.009","article-title":"Colorectal\nPeritoneal Carcinomatosis: What Is the Future of HIPEC?","volume":"44","author":"Que\u0301net","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"2026081810213025000_cit5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1200\/JCO.2009.23.9285","article-title":"Peritoneal Colorectal Carcinomatosis Treated with Surgery\nand Perioperative Intraperitoneal Chemotherapy: Retrospective Analysis\nof 523 Patients from a Multicentric French Study","volume":"28","author":"Elias","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"2026081810213025000_cit6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.pdpdt.2017.10.021","article-title":"Treatment\nof Peritoneal\nCarcinomatosis with Photodynamic Therapy: Systematic Review of Current\nEvidence","volume":"20","author":"Almerie","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"2026081810213025000_cit7","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/978-0-387-48993-3_34","article-title":"Intraperitoneal Photodynamic Therapy","volume":"134","author":"Cengel","year":"2007","journal-title":"Cancer Treat. Res."},{"key":"2026081810213025000_cit8","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1515\/pp-2018-0124","article-title":"Photodynamic Therapy and Photothermal\nTherapy for the\nTreatment of Peritoneal Metastasis: A Systematic Review","volume":"3","author":"Pinto","year":"2018","journal-title":"Pleura Peritoneum"},{"key":"2026081810213025000_cit9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.pdpdt.2011.10.001","article-title":"MTHPC -\nA Drug on Its Way from Second to Third Generation Photosensitizer?","volume":"9","author":"Senge","year":"2012","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"2026081810213025000_cit10","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.pdpdt.2015.07.005","article-title":"Assessment\nof the Specificity of a New Folate-Targeted Photosensitizer for Peritoneal\nMetastasis of Epithelial Ovarian Cancer to Enable Intraperitoneal\nPhotodynamic Therapy. A Preclinical Study","volume":"13","author":"Azai\u0308s","year":"2016","journal-title":"Photodiagn.\nPhotodyn. Ther."},{"key":"2026081810213025000_cit11","doi-asserted-by":"publisher","first-page":"775","DOI":"10.7314\/APJCP.2016.17.2.775","article-title":"A Strategy\nUsing Photodynamic Therapy and Clofibric Acid to Treat Peritoneal\nDissemination of Ovarian Cancer","volume":"17","author":"Yokoyama","year":"2016","journal-title":"Asian Pac.\nJ. Cancer Prev."},{"key":"2026081810213025000_cit12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/lsm.10113","article-title":"Experimental Photodynamic Therapy\nfor Malignant Pleural\nMesothelioma with Pegylated mTHPC","volume":"32","author":"Krueger","year":"2003","journal-title":"Lasers Surg.\nMed."},{"key":"2026081810213025000_cit13","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1007\/s11095-008-9590-7","article-title":"Photocytotoxicity\nof mTHPC (Temoporfin)\nLoaded Polymeric Micelles Mediated by Lipase Catalyzed Degradation","volume":"25","author":"Hofman","year":"2008","journal-title":"Pharm. Res."},{"key":"2026081810213025000_cit14","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tiv.2006.09.006","article-title":"Cationic Liposomes,\nLoaded with mTHPC, in Photodynamic Therapy for Malignant Glioma","volume":"21","author":"Molinari","year":"2007","journal-title":"Toxicol. In Vitro"},{"issue":"5","key":"2026081810213025000_cit15","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/j.1751-1097.2007.00146.x","article-title":"Tumor Selectivity at\nShort Times following Systemic Administration of a Liposomal Temoporfin\nFormulation in a Murine Tumor Model","volume":"83","author":"Svensson","year":"2007","journal-title":"Photochem.\nPhotobiol."},{"key":"2026081810213025000_cit16","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jconrel.2008.11.016","article-title":"Correlation\nbetween in Vivo Pharmacokinetics, Intratumoral Distribution\nand Photodynamic Efficiency\nof Liposomal mTHPC","volume":"134","author":"Lassalle","year":"2009","journal-title":"J. Controlled Release"},{"key":"2026081810213025000_cit17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3389\/fphar.2019.00669","article-title":"Exploring\nthe Use of Pegylated Liposomal Doxorubicin (Caelyx) as Pressurized\nIntraperitoneal Aerosol Chemotherapy","volume":"10","author":"Robella","year":"2019","journal-title":"Front.\nPharmacol."},{"key":"2026081810213025000_cit18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejso.2019.03.035","article-title":"Pharmacokinetics of the Intraperitoneal Nanoparticle\nPegylated Liposomal Doxorubicin in Patients with Peritoneal Metastases","volume":"47","author":"Sugarbaker","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"2026081810213025000_cit19","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.7150\/jca.26860","article-title":"Effect of\nLiposomal Doxorubicin in\nPressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC)","volume":"9","author":"Mikolajczyk","year":"2018","journal-title":"J. Cancer"},{"key":"2026081810213025000_cit20","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.tibtech.2017.03.004","article-title":"Exosomes\nin Cancer Nanomedicine and Immunotherapy: Prospects and Challenges","volume":"35","author":"Syn","year":"2017","journal-title":"Trends Biotechnol."},{"key":"2026081810213025000_cit21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.crvi.2011.12.006","article-title":"Cell-Derived\nMicrovesicles and Antitumoral Multidrug Resistance","volume":"335","author":"Tatischeff","year":"2012","journal-title":"C. R. Biol."},{"key":"2026081810213025000_cit22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.addr.2016.02.006","article-title":"Extracellular\nVesicles for Drug Delivery","volume":"106","author":"Vader","year":"2016","journal-title":"Adv. Drug Delivery\nRev."},{"key":"2026081810213025000_cit23","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1021\/nn400269x","article-title":"Magnetic and\nPhotoresponsive Theranosomes: Translating Cell-Released Vesicles into\nSmart Nanovectors for Cancer Therapy","volume":"7","author":"Silva","year":"2013","journal-title":"ACS Nano"},{"key":"2026081810213025000_cit24","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1080\/10717544.2018.1513609","article-title":"mTHPC-Loaded\nExtracellular Vesicles Outperform Liposomal\nand Free mTHPC Formulations by an Increased Stability, Drug Delivery\nEfficiency and Cytotoxic Effect in Tridimensional Model of Tumors","volume":"25","author":"Millard","year":"2018","journal-title":"Drug Delivery"},{"key":"2026081810213025000_cit25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3390\/pharmaceutics12070676","article-title":"mTHPC-Loaded Extracellular Vesicles\nSignificantly Improve mTHPC Diffusion and Photodynamic Activity in\nPreclinical Models","volume":"12","author":"Millard","year":"2020","journal-title":"Pharmaceutics"},{"key":"2026081810213025000_cit26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fphar.2018.00259","article-title":"Application\nof Mesenchymal Stem Cells for Therapeutic\nAgent Delivery in Anti-Tumor Treatment","volume":"9","author":"Chulpanova","year":"2018","journal-title":"Front.\nPharmacol."},{"key":"2026081810213025000_cit27","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3892\/or.2019.7198","article-title":"Targeting the Differentiation of\nGastric Cancer Cells (KATO-III) Downregulates Epithelial-Mesenchymal\nand Cancer Stem Cell Markers","volume":"42","author":"Shah","year":"2019","journal-title":"Oncol. Rep."},{"key":"2026081810213025000_cit28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.addr.2011.06.010","article-title":"Mesenchymal\nStem Cells Engineered for Cancer Therapy","volume":"64","author":"Shah","year":"2012","journal-title":"Adv.\nDrug Delivery Rev."},{"key":"2026081810213025000_cit29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/vaccines6030054","article-title":"Early Investigations and Recent Advances\nin Intraperitoneal\nImmunotherapy for Peritoneal Metastasis","volume":"6","author":"Thadi","year":"2018","journal-title":"Vaccines"},{"key":"2026081810213025000_cit30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/1011-1344(94)07090-B","article-title":"Correlation between Meta-Tetra (thydroxyphenyl)\nChlorin (mTHPC) Biodistribution and Photodynamic Effects in Mice","volume":"28","author":"Morlet","year":"1995","journal-title":"J. Photochem. Photobiol., B"},{"key":"2026081810213025000_cit31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/(SICI)1097-0215(19971009)73:2&lt;230::AID-IJC12&gt;3.0.CO;2-J","article-title":"Foscan-Mediated Photodynamic Therapy\nfor a Peritoneal-Cancer Model: Drug Distribution and Efficacy Studies","volume":"73","author":"Veenhuizen","year":"1997","journal-title":"Int. J. Cancer"},{"key":"2026081810213025000_cit32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.biocel.2019.02.001","article-title":"Encapsulated Human Mesenchymal Stem\nCells (EMSCs) as\na Novel Anti-Cancer Agent Targeting Breast Cancer Stem Cells: Development\nof 3D Primed Therapeutic MSCs","volume":"110","author":"Mandal","year":"2019","journal-title":"Int. J. Biochem.\nCell Biol."},{"key":"2026081810213025000_cit33","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/sctm.18-0226","article-title":"Mesenchymal\nStem Cell-Derived Extracellular Vesicles as Therapeutics and as a\nDrug Delivery Platform","volume":"8","author":"Baek","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"2026081810213025000_cit34","doi-asserted-by":"publisher","first-page":"30418","DOI":"10.1038\/srep30418","article-title":"In Vivo Therapeutic Potential of Mesenchymal Stem Cell-Derived\nExtracellular Vesicles with Optical Imaging Reporter in Tumor Mice\nModel","volume":"6","author":"Kalimuthu","year":"2016","journal-title":"Sci. Rep."},{"key":"2026081810213025000_cit35","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1039\/c0pp00303d","article-title":"Redistribution of Meta-Tetra (hydroxyphenyl)\nChlorin (mTHPC) from Conventional and PEGylated Liposomes to Biological\nSubstrates","volume":"10","author":"Reshetov","year":"2011","journal-title":"Photochem. Photobiol. Sci."},{"key":"2026081810213025000_cit36","first-page":"2983","article-title":"Treatment of Murine\nIntraperitoneal Ovarian Ascitic Tumor with Hematoporphyrin\nDerivative and Laser Light","volume":"45","author":"Tochner","year":"1985","journal-title":"Cancer Res."},{"key":"2026081810213025000_cit37","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1751-1097.1991.tb03637.x","article-title":"Intravenous vs Intraperitoneal Sensitizer:\nImplications for Intraperitoneal\nPhotodynamic Therapy","volume":"53","author":"Perry","year":"1991","journal-title":"Photochem. Photobiol."},{"key":"2026081810213025000_cit38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.pdpdt.2008.09.004","article-title":"Comparison of Continuous\nand Fractionated Illumination\nduring Hexaminolaevulinate-Photodynamic Therapy","volume":"5","author":"Ascencio","year":"2008","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"2026081810213025000_cit39","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1158\/1535-7163.MCT-16-0670","article-title":"Maltotriose Conjugation\nto a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic\nTherapy in Peritoneal Dissemination of Pancreatic Cancer","volume":"16","author":"Kato","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"2026081810213025000_cit40","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/jbio.201300133","article-title":"Pharmacokinetic and Biodistribution Study Following\nSystemic Administration of Fospeg\u00ae - A Pegylated Liposomal mTHPC\nFormulation in a Murine Model: Pharmacokinetic and Biodistribution\nStudy Following Systemic Administration of Fospeg\u00ae","volume":"8","author":"Xie","year":"2015","journal-title":"J. Biophotonics"},{"key":"2026081810213025000_cit41","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.trecan.2019.12.008","article-title":"Targeting\nthe Tumor Microenvironment in Colorectal Peritoneal Metastases","volume":"6","author":"Ceelen","year":"2020","journal-title":"Trends Cancer"},{"key":"2026081810213025000_cit42","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3390\/jcm9020333","article-title":"Preclinical and Clinical Evidence\nof Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical\nRecommendations","volume":"9","author":"Beltra\u0301n\nHerna\u0301ndez","year":"2020","journal-title":"J. Clin. Med."},{"key":"2026081810213025000_cit43","doi-asserted-by":"publisher","first-page":"103249","DOI":"10.1016\/j.bioorg.2019.103249","article-title":"Immunomodulatory\nActivities of Zinc\u00ad(II)\u00adPhthalocyanine\non the Mammalian Macrophages through P38 Pathway: Potential ex Vivo Immunomodulatory PDT Reagents","volume":"92","author":"Yu\u0308zer","year":"2019","journal-title":"Bioorg. Chem."},{"key":"2026081810213025000_cit44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.addr.2015.11.005","article-title":"Designing Liposomal Adjuvants for\nthe Next Generation of Vaccines","volume":"99","author":"Perrie","year":"2016","journal-title":"Adv. Drug Delivery\nRev."},{"key":"2026081810213025000_cit45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fcell.2020.00072","article-title":"Mesenchymal Stem Cells\nbeyond Regenerative Medicine","volume":"8","author":"Shammaa","year":"2020","journal-title":"Front. Cell Dev.\nBiol."},{"key":"2026081810213025000_cit46","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic Therapy and Anti-Tumour\nImmunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2026081810213025000_cit47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pdpdt.2014.11.002","article-title":"Light Emitting Fabric\nTechnologies for Photodynamic\nTherapy","volume":"12","author":"Mordon","year":"2015","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"2026081810213025000_cit48","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1002\/1873-3468.13472","article-title":"Content Release of\nExtracellular Vesicles in a Cell-Free\nExtract","volume":"593","author":"Bonsergent","year":"2019","journal-title":"FEBS Lett."},{"key":"2026081810213025000_cit49","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ijrobp.2010.04.009","article-title":"Compartmental\nTargeting for mTHPC-Based Photodynamic Treatment in Vivo: Correlation of Efficiency, Pharmacokinetics, and Regional Distribution\nof Apoptosis","volume":"78","author":"Garrier","year":"2010","journal-title":"Int. J. Radiat. Oncol., Biol.,\nPhys."},{"key":"2026081810213025000_cit50","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1593\/tlo.09295","article-title":"Intratumor\nAdministration of the Photosensitizer Pc 4 Affords Photodynamic Therapy\nEfficacy and Selectivity at Short Drug-Light Intervals","volume":"3","author":"Foster","year":"2010","journal-title":"Transl. Oncol."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.0c09938","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/15\/2\/3251\/16504465\/nn0c09938.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/15\/2\/3251\/16504465\/nn0c09938.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:12:58Z","timestamp":1787069578000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/15\/2\/3251\/1552095\/Immune-Reprogramming-Precision-Photodynamic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,22]]},"published-print":{"date-parts":[[2021,2,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.0c09938","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]}}}