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The current PM treatment combines cytoreductive surgery, which consists of resecting all macroscopic tumors, with hyperthermic intraperitoneal chemotherapy (HIPEC), which uses mild hyperthermia to boost the diffusion and cytotoxic effect of chemotherapeutic drugs. As HIPEC is performed via a closed circulation of a hot liquid containing chemotherapy, it induces uncontrolled heating and drug distribution in the whole peritoneal cavity with important off-site toxicity and a high level of morbidity. Here, we propose a safer precision strategy using near-infrared (NIR) photoactivated gold nanoparticles (AuNPs) coupled to the chemotherapeutic drug 5-fluorouracil (5-FU) to enable a spatial and temporal control of mild chemo-hyperthermia targeted to the tumor nodules within the peritoneal cavity. Both the 16 nm AuNPs and the corresponding complex with 5-FU (AuNP\u20135-FU) were shown as efficient NIR photothermal agents in the microenvironment of subcutaneous colon tumors as well as PM in syngeneic mice. Noteworthy, NIR photothermia provided additional antitumor effects to 5-FU treatment. A single intraperitoneal administration of AuNP\u20135-FU resulted in their preferential accumulation in tumor nodules and peritoneal macrophages, allowing light-induced selective hyperthermia, extended tumor necrosis, and activation of a pro-inflammatory immune response while leaving healthy tissues without any damage. From a translational standpoint, the combined and tumor-targeted photothermal and chemotherapy mediated by the AuNP\u2013drug complex has the potential to overcome the current off-target toxicity of HIPEC in clinical practice.<\/jats:p>","DOI":"10.1021\/acsnano.0c10276","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T06:26:00Z","timestamp":1612592760000},"page":"3330-3348","source":"Crossref","is-referenced-by-count":66,"title":["Tumor-Selective\nImmune-Active Mild Hyperthermia Associated\nwith Chemotherapy in Colon Peritoneal Metastasis by Photoactivation\nof Fluorouracil\u2013Gold Nanoparticle Complexes"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3549-0700","authenticated-orcid":true,"given":"Vladimir","family":"Mulens-Arias","sequence":"first","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]},{"name":"National Center for Biotechnology\/CSIC , , Darwin 3, Cantoblanco Campus, ,","place":["Madrid, Spain, 28049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Nicola\u0301s-Boluda","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Pinto","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , ,","place":["Paris, France, F-75010"]},{"name":"Ho\u0302pital Lariboisie\u0300re , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Balfourier","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-3658","authenticated-orcid":true,"given":"Florent","family":"Carn","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda K. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pocard","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , ,","place":["Paris, France, F-75010"]},{"name":"Ho\u0302pital Lariboisie\u0300re , , 2 rue Ambroise Pare\u0301 , ,","place":["Paris, France, F-75010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-3597","authenticated-orcid":true,"given":"Florence","family":"Gazeau","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Paris , , 10 Rue Alice Domon et Le\u0301onie Duquet , ,","place":["Paris, France, 75205 Cedex 13"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"2026081810210611200_cit1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejca.2017.07.016","article-title":"Understanding\nthe Role of Primary Tumour Localisation in Colorectal Cancer Treatment\nand Outcomes","volume":"84","author":"Stintzing","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"2026081810210611200_cit2","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO Consensus Guidelines for the Management\nof Patients with Metastatic Colorectal Cancer","volume":"27","author":"Van\nCutsem","year":"2016","journal-title":"Ann. Oncol."},{"key":"2026081810210611200_cit3","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/jso.24774","article-title":"Personalizing Prognosis in Colorectal Cancer: A Systematic\nReview of the Quality and Nature of Clinical Prognostic Tools for\nSurvival Outcomes","volume":"116","author":"Mahar","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"2026081810210611200_cit4","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/S1470-2045(16)30500-9","article-title":"Prognosis\nof Patients with Peritoneal Metastatic Colorectal Cancer Given Systemic\nTherapy: An Analysis of Individual Patient Data from Prospective Randomised\nTrials from the Analysis and Research in Cancers of the Digestive\nSystem (ARCAD) Database","volume":"17","author":"Franko","year":"2016","journal-title":"Lancet Oncol."},{"key":"2026081810210611200_cit5","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1200\/JCO.2003.04.187","article-title":"Randomized\nTrial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients\nwith Peritoneal Carcinomatosis of Colorectal Cancer","volume":"21","author":"Verwaal","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"2026081810210611200_cit6","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1200\/JCO.2008.19.7160","article-title":"Complete Cytoreductive Surgery Plus\nIntraperitoneal Chemohyperthermia with Oxaliplatin for Peritoneal\nCarcinomatosis of Colorectal Origin","volume":"27","author":"Elias","year":"2009","journal-title":"J. Clin.\nOncol."},{"key":"2026081810210611200_cit7","doi-asserted-by":"publisher","first-page":"5608","DOI":"10.1002\/cncr.25356","article-title":"Toward Curative Treatment of Peritoneal Carcinomatosis from Nonovarian\nOrigin by Cytoreductive Surgery Combined with Perioperative Intraperitoneal\nChemotherapy: a Multi-Institutional Study of 1,290 Patients","volume":"116","author":"Glehen","year":"2010","journal-title":"Cancer"},{"key":"2026081810210611200_cit8","doi-asserted-by":"publisher","first-page":"LBA3503","DOI":"10.1200\/JCO.2018.36.18_suppl.LBA3503","article-title":"A UNICANCER\nPhase III Trial of Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC)\nfor Colorectal Peritoneal Carcinomatosis (PC): PRODIGE 7","volume":"36","author":"Quenet","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"2026081810210611200_cit9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4251\/wjgo.v2.i2.109","article-title":"A Pharmacological\nReview on Intraperitoneal\nChemotherapy for Peritoneal Malignancy","volume":"2","author":"Yan","year":"2010","journal-title":"World\nJ. Gastrointest. Oncol."},{"key":"2026081810210611200_cit10","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1245\/ASO.2003.01.018","article-title":"Intraperitoneal\nChemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive\nSurgery for the Treatment of Peritoneal Carcinomatosis: Morbidity\nand Mortality Analysis of 216 Consecutive Procedures","volume":"10","author":"Glehen","year":"2003","journal-title":"Ann. Surg. Oncol."},{"key":"2026081810210611200_cit11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1245\/s10434-015-4699-5","article-title":"Treatment-Related\nMortality After Cytoreductive Surgery and HIPEC in Patients with Colorectal\nPeritoneal Carcinomatosis is Underestimated by Conventional Parameters","volume":"23","author":"Simkens","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"2026081810210611200_cit12","doi-asserted-by":"publisher","first-page":"14018","DOI":"10.3748\/wjg.v20.i38.14018","article-title":"Cytoreductive\nSurgery and Intraperitoneal Chemotherapy for Colorectal Peritoneal\nMetastases","volume":"20","author":"Mirnezami","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"2026081810210611200_cit13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3978\/j.issn.2078-6891.2015.100","article-title":"Cytoreductive\nSurgery and Hyperthermic\nIntraperitoneal Chemotherapy: a Review of Factors Contributing to\nMorbidity and Mortality","volume":"7","author":"Newton","year":"2016","journal-title":"J. Gastrointest. Oncol."},{"key":"2026081810210611200_cit14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.suronc.2016.05.025","article-title":"Enterocutaneous\nFistula in Patients with Peritoneal\nMalignancy Following Cytoreductive Surgery and Hyperthermic Intraperitoneal\nChemotherapy: Incidence, Management and Outcomes","volume":"25","author":"Valle","year":"2016","journal-title":"Surg. Oncol."},{"key":"2026081810210611200_cit15","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.4155\/tde.11.72","article-title":"Nanoparticle-Mediated Hyperthermia\nin Cancer Therapy","volume":"2","author":"Chatterjee","year":"2011","journal-title":"Ther. Delivery"},{"key":"2026081810210611200_cit16","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1016\/j.clcc.2019.02.001","article-title":"A Review on the\nScope of Photothermal\nTherapy\u2013Based Nanomedicines in Preclinical Models of Colorectal\nCancer","volume":"18","author":"Khot","year":"2019","journal-title":"Clin. Colorectal Cancer"},{"key":"2026081810210611200_cit17","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1021\/mp800250e","article-title":"Rapid\nPhotothermal Intracellular Drug Delivery Using Multiwalled Carbon\nNanotubes","volume":"6","author":"Levi-Polyachenko","year":"2009","journal-title":"Mol. Pharmaceutics"},{"key":"2026081810210611200_cit18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2131\/jts.33.105","article-title":"Induction of Mesothelioma\nin p53\u00b1 Mouse by Intraperitoneal Application of Multi-Wall Carbon\nNanotube","volume":"33","author":"Takagi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"2026081810210611200_cit19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12989-014-0059-z","article-title":"The Carcinogenic Effect of Various\nMulti-Walled Carbon Nanotubes (MWCNTs) After Intraperitoneal Injection\nin Rats","volume":"11","author":"Rittinghausen","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"2026081810210611200_cit20","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1093\/toxsci\/kfp100","article-title":"Absence of Carcinogenic\nResponse to Multiwall Carbon Nanotubes in\na 2-Year Bioassay in the Peritoneal Cavity of the Rat","volume":"110","author":"Muller","year":"2009","journal-title":"Toxicol. Sci."},{"key":"2026081810210611200_cit21","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.1021\/nn4033757","article-title":"Plasmonic Photothermal\nHeating of Intraperitoneal Tumors through the Use of an Implanted\nNear-Infrared Source","volume":"7","author":"Bagley","year":"2013","journal-title":"ACS Nano"},{"key":"2026081810210611200_cit22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/lsm.22356","article-title":"Localized\nThermal Tumor Destruction Using Dye-Enhanced Photothermal Tumor Therapy","volume":"47","author":"Diddens-Tschoeke","year":"2015","journal-title":"Lasers Surg. Med."},{"key":"2026081810210611200_cit23","doi-asserted-by":"publisher","first-page":"26861","DOI":"10.18632\/oncotarget.4766","article-title":"Nanoparticle-Induced Intraperitoneal\nHyperthermia and Targeted Photoablation in Treating Ovarian Cancer","volume":"6","author":"Wu","year":"2015","journal-title":"Oncotarget"},{"key":"2026081810210611200_cit24","doi-asserted-by":"publisher","first-page":"78208","DOI":"10.18632\/oncotarget.20596","article-title":"Nanoparticle as a Novel\nTool in Hyperthermic Intraperitoneal\nand Pressurized Intraperitoneal Aerosol Chemotherapy to Treat Patients\nwith Peritoneal Carcinomatosis","volume":"8","author":"Nowacki","year":"2017","journal-title":"Oncotarget"},{"key":"2026081810210611200_cit25","doi-asserted-by":"publisher","first-page":"1801022","DOI":"10.1002\/smll.201801022","article-title":"Intraoperative Raman-Guided Chemo-Photothermal\nSynergistic Therapy of Advanced Disseminated Ovarian Cancers","volume":"14","author":"Zhang","year":"2018","journal-title":"Small"},{"key":"2026081810210611200_cit26","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.3390\/ijms19071979","article-title":"Gold Nanoparticles in Diagnostics and Therapeutics\nfor Human Cancer","volume":"19","author":"Singh","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810210611200_cit27","doi-asserted-by":"publisher","first-page":"e1449","DOI":"10.1002\/wnan.1449","article-title":"Gold Nanoparticle-Mediated\nPhotothermal Therapy: Applications\nand Opportunities for Multimodal Cancer Treatment","volume":"9","author":"Riley","year":"2017","journal-title":"WIREs. Nanomed. Nanobiotechnol."},{"key":"2026081810210611200_cit28","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1039\/C3NR04448C","article-title":"Multifunctional\nGold Coated Thermo-Sensitive Liposomes for Multimodal Imaging and\nPhoto-Thermal Therapy of Breast Cancer Cells","volume":"6","author":"Rengan","year":"2014","journal-title":"Nanoscale"},{"key":"2026081810210611200_cit29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1073\/pnas.1911734116","article-title":"Unexpected\nIntracellular Biodegradation and Recrystallization of Gold Nanoparticles","volume":"117","author":"Balfourier","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026081810210611200_cit30","doi-asserted-by":"publisher","first-page":"21832","DOI":"10.1039\/D0NR05886F","article-title":"Endocytosis-Driven\nGold Nanoparticle Fractal Rearrangement\nin Cells and its Influence on Photothermal Conversion","volume":"12","author":"Mulens-Arias","year":"2020","journal-title":"Nanoscale"},{"key":"2026081810210611200_cit31","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1097\/IGC.0000000000000664","article-title":"Heated IntraPEritoneal Chemotherapy (HIPEC) for Patients\nwith Recurrent Ovarian Cancer: A Systematic Literature Review","volume":"26","author":"Hotouras","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"2026081810210611200_cit32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jso.24906","article-title":"5-Fluorouracil Combined\nwith Cisplatin and Mitomycin C as an Optimized\nRegimen for Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer","volume":"117","author":"Murata","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"2026081810210611200_cit33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1023\/A:1006416410198","article-title":"5-Fluorouracil:\nForty-Plus and Still Ticking. A Review of its Preclinical and Clinical\nDevelopment","volume":"18","author":"Grem","year":"2000","journal-title":"Invest. New Drugs"},{"key":"2026081810210611200_cit34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.5301\/tj.5000652","article-title":"A Correlation Study\nof Fluorouracil Pharmacodynamics with Clinical Efficacy and Toxicity","volume":"104","author":"Esin","year":"2018","journal-title":"Tumori"},{"key":"2026081810210611200_cit35","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1097\/CAD.0000000000000546","article-title":"Prediction of Severe Toxicity in\nAdult Patients Under Treatment with 5-Fluorouracil: a Prospective\nCohort Study","volume":"28","author":"Vazquez","year":"2017","journal-title":"Anti-Cancer Drugs"},{"key":"2026081810210611200_cit36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/jbm.a.30654","article-title":"Biodegradable Polymeric\nMicrospheres and Nanospheres\nfor Drug Delivery in the Peritoneum","volume":"77A","author":"Kohane","year":"2006","journal-title":"J. Biomed.\nMater. Res., Part A"},{"key":"2026081810210611200_cit37","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrclinonc.2010.139","article-title":"Delivering Nanomedicine to Solid Tumors","volume":"7","author":"Jain","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2026081810210611200_cit38","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3109\/02656730903479855","article-title":"The Effect of Mild\nTemperature Hyperthermia on Tumour Hypoxia and Blood Perfusion: Relevance\nfor Radiotherapy, Vascular Targeting and Imaging","volume":"26","author":"Sun","year":"2010","journal-title":"Int. J. Hyperthermia"},{"key":"2026081810210611200_cit39","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s12967-019-2094-x","article-title":"Mild Hyperthermia\nby MR-Guided Focused\nUltrasound in an ex Vivo Model of Osteolytic Bone\nTumour: Optimization of the Spatio-Temporal Control of the Delivered\nTemperature","volume":"17","author":"Guillemin","year":"2019","journal-title":"J. Transl. Med."},{"key":"2026081810210611200_cit40","doi-asserted-by":"publisher","first-page":"11098","DOI":"10.1021\/la201938u","article-title":"Kinetically\nControlled Seeded Growth\nSynthesis of Citrate-Stabilized Gold Nanoparticles of Up to 200 nm:\nSize Focusing versus Ostwald Ripening","volume":"27","author":"Bastu\u0301s","year":"2011","journal-title":"Langmuir"},{"key":"2026081810210611200_cit41","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1021\/acs.chemmater.5b04406","article-title":"Size-Controlled Synthesis of Sub-10-Nanometer\nCitrate-Stabilized Gold Nanoparticles and Related Optical Properties","volume":"28","author":"Piella","year":"2016","journal-title":"Chem. Mater."},{"issue":"10","key":"2026081810210611200_cit42","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.4172\/2157-7439.1000146","article-title":"5-Fluorouracil Induces\nPlasmonic Coupling in Gold Nanospheres: New Generation of Chemotherapeutic\nAgents","volume":"3","author":"Mohamed","year":"2012","journal-title":"J. Nanomed. Nanotechnol."},{"key":"2026081810210611200_cit43","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1039\/C8NR09849B","article-title":"Polyethyleneimine-Assisted\nOne-Pot\nSynthesis of Quasi-Fractal Plasmonic Gold Nanocomposites as a Photothermal\nTheranostic Agent","volume":"11","author":"Mulens-Arias","year":"2019","journal-title":"Nanoscale"},{"key":"2026081810210611200_cit44","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1021\/acs.jpcb.9b09590","article-title":"Self-Assembly of Gold\nNanoparticles with Oppositely Charged, Long, Linear Chains of Periodic\nCopolymers","volume":"124","author":"Bridonneau","year":"2020","journal-title":"J. Phys. Chem. B"},{"key":"2026081810210611200_cit45","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.1021\/acs.langmuir.5b00854","article-title":"Shape-Tailored Colloidal\nMolecules Obtained by Self-Assembly of Model Gold Nanoparticles with\nFlexible Polyelectrolyte","volume":"31","author":"Shi","year":"2015","journal-title":"Langmuir"},{"key":"2026081810210611200_cit46","doi-asserted-by":"publisher","first-page":"104513","DOI":"10.1039\/C6RA18196A","article-title":"A DFT Study\non the Interaction Between 5-Fluorouracil and B12N12 Nanocluster","volume":"6","author":"Javan","year":"2016","journal-title":"RSC Adv."},{"key":"2026081810210611200_cit47","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1186\/1556-276X-9-454","article-title":"Quantifying Spectral Changes Experienced\nby Plasmonic Nanoparticles in a Cellular Environment to Inform Biomedical\nNanoparticle Design","volume":"9","author":"Chen","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"2026081810210611200_cit48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/02656736.2020.1714084","article-title":"Moderate\nHyperthermic\nHeating Encountered during Thermal Ablation Increases Tumor Cell Activity","volume":"37","author":"Markezana","year":"2020","journal-title":"Int. J. Hyperthermia"},{"key":"2026081810210611200_cit49","doi-asserted-by":"publisher","first-page":"2006824","DOI":"10.1002\/adfm.202006824","article-title":"Self-Assemblies\nof Fe3O4 Nanocrystals: Toward Nanoscale Precision of Photothermal\nEffects in the Tumor Microenvironment","volume":"31","author":"Nicolas-Boluda","year":"2021","journal-title":"Adv.\nFunct. Mater."},{"key":"2026081810210611200_cit50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dow026","article-title":"Low-Dose Hyperthermia\nEnhances the Antitumor Effects\nof Chemotherapy in Squamous Cell Carcinoma","volume":"30","author":"Hu","year":"2017","journal-title":"Dis. 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