{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:23:59Z","timestamp":1793741039714,"version":"4.6.1"},"reference-count":300,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018ZX09721003-008-017"],"award-info":[{"award-number":["2018ZX09721003-008-017"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFC1708901"],"award-info":[{"award-number":["2019YFC1708901"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2020-12M-2-010"],"award-info":[{"award-number":["2020-12M-2-010"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-1-I2M-009"],"award-info":[{"award-number":["2021-1-I2M-009"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-1-I2M-030"],"award-info":[{"award-number":["2021-1-I2M-030"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-dysfunction-associated fatty liver disease (MAFLD), affects a quarter of the worldwide population. Natural products have been extensively utilized in treating NAFLD because of their distinctive advantages over chemotherapeutic drugs, despite the fact that there are no approved drugs for therapy. Notably, the limitations of many natural products, such as poor water solubility, low bioavailability in vivo, low hepatic distribution, and lack of targeted effects, have severely restricted their clinical application. These issues could be resolved via hepatic targeted drug delivery systems (HTDDS) that boost clinical efficacy in treating NAFLD and decrease the adverse effects on other organs. Herein an overview of natural products comprising formulas, single medicinal plants, and their crude extracts has been presented to treat NAFLD. Also, the clinical efficacy and molecular mechanism of active monomer compounds against NAFLD are systematically discussed. The targeted delivery of natural products via HTDDS has been explored to provide a different nanotechnology-based NAFLD treatment strategy and to make suggestions for natural-product-based targeted nanocarrier design. Finally, the challenges and opportunities put forth by the nomenclature update of NAFLD are outlined along with insights into how to improve the NAFLD therapy and how to design more rigorous nanocarriers for the HTDDS. In brief, we summarize the up-to-date developments of the NAFLD-HTDDS based on natural products and provide viewpoints for the establishment of more stringent anti-NAFLD natural-product-targeted nanoformulations.<\/jats:p>","DOI":"10.1021\/acsnano.1c02158","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T12:07:24Z","timestamp":1635336444000},"page":"17016-17046","source":"Crossref","is-referenced-by-count":53,"title":["Design\nof Hepatic Targeted Drug Delivery Systems for\nNatural Products: Insights into Nomenclature Revision of Nonalcoholic\nFatty Liver Disease"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-0379","authenticated-orcid":true,"given":"Rou","family":"Tang","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-2476","authenticated-orcid":true,"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lei","family":"Ma","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Du","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-You","family":"Yu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ren","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Sheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"2026081810123401500_cit1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A Consensus-Driven Proposed\nNomenclature for Metabolic Associated Fatty Liver Disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"2026081810123401500_cit2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A New Definition for Metabolic Dysfunction-Associated\nFatty Liver Disease: An International Expert Consensus Statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"2026081810123401500_cit3","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1053\/j.gastro.2019.05.064","article-title":"Toward More Accurate\nNomenclature\nfor Fatty Liver Diseases","volume":"157","author":"Eslam","year":"2019","journal-title":"Gastroenterology"},{"key":"2026081810123401500_cit4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41575-020-0316-6","article-title":"From NAFLD\nto MAFLD: When Pathophysiology Succeeds","volume":"17","author":"Tilg","year":"2020","journal-title":"Nat.\nRev. Gastroenterol. Hepatol."},{"key":"2026081810123401500_cit5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/hep.28276","article-title":"Time to\nAbandon NASH?","volume":"63","author":"Dufour","year":"2016","journal-title":"Hepatology"},{"key":"2026081810123401500_cit6","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian\nPacific Association for\nthe Study of the Liver Clinical Practice Guidelines for the Diagnosis\nand Management of Metabolic Associated Fatty Liver Disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"2026081810123401500_cit7","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The Diagnosis\nand Management of Nonalcoholic Fatty Liver Disease: Practice Guidance\nfrom the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"2026081810123401500_cit8","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Nonalcoholic Steatohepatitis Clinical Research, N.,\nDesign and Validation of a Histological Scoring System for Nonalcoholic\nFatty Liver Disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"2026081810123401500_cit9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1053\/j.gastro.2005.11.017","article-title":"From Fat\nto Inflammation","volume":"130","author":"Day","year":"2006","journal-title":"Gastroenterology"},{"key":"2026081810123401500_cit10","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms\nof NAFLD Development and Therapeutic Strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"2026081810123401500_cit11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-pathol-020117-043617","article-title":"Recent Insights into the Pathogenesis\nof Nonalcoholic Fatty Liver Disease","volume":"13","author":"Arab","year":"2018","journal-title":"Annu. Rev.\nPathol.: Mech. Dis."},{"key":"2026081810123401500_cit12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, Present\nand Future Perspectives in Nonalcoholic Fatty Liver Disease","volume":"16","author":"Sanyal","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026081810123401500_cit13","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes\nin the Global Burden of Chronic Liver Diseases from 2012 to 2017:\nThe Growing Impact of Nonalcoholic Fatty Liver Disease","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"key":"2026081810123401500_cit14","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic Fatty Liver Disease 2020: The State of\nthe Disease","volume":"158","author":"Cotter","year":"2020","journal-title":"Gastroenterology"},{"key":"2026081810123401500_cit15","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global\nPerspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic\nSteatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"2026081810123401500_cit16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global Epidemiology\nof Nonalcoholic Fatty Liver Disease\ue5f8Meta-Analytic\nAssessment of Prevalence, Incidence, and Outcome","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"2026081810123401500_cit17","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected Rapid Increase in the\nBurden of NAFLD in China from 2008\nto 2018: A Systematic Review and Meta-Analysis","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"2026081810123401500_cit18","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","article-title":"Treatment of NAFLD with Diet, Physical\nActivity and Exercise","volume":"67","author":"Romero-Go\u0301mez","year":"2017","journal-title":"J. Hepatol."},{"key":"2026081810123401500_cit19","doi-asserted-by":"publisher","first-page":"m4747","DOI":"10.1136\/bmj.m4747","article-title":"Management\nof Non-Alcoholic Fatty Liver Disease","volume":"372","author":"Petroni","year":"2021","journal-title":"BMJ."},{"key":"2026081810123401500_cit20","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.3390\/ijms22052350","article-title":"Treatments for NAFLD:\nState of Art","volume":"22","author":"Mantovani","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810123401500_cit21","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/hepr.13425","article-title":"Phase 3 Drug\nPipelines in the Treatment of Non-Alcoholic Steatohepatitis","volume":"49","author":"Sumida","year":"2019","journal-title":"Hepatol. Res."},{"key":"2026081810123401500_cit22","doi-asserted-by":"publisher","first-page":"1801585","DOI":"10.1002\/advs.201801585","article-title":"Insights into the Epidemiology, Pathogenesis,\nand Therapeutics of Nonalcoholic Fatty Liver Diseases","volume":"6","author":"Yu","year":"2019","journal-title":"Adv. Sci."},{"key":"2026081810123401500_cit23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.nano.2006.11.008","article-title":"The Present and Future of Nanotechnology\nin Human Health Care","volume":"3","author":"Sahoo","year":"2007","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit24","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.biopha.2017.11.026","article-title":"Nanotherapeutics: An\nInsight into Healthcare and Multi-Dimensional\nApplications in Medical Sector of the Modern World","volume":"97","author":"Prasad","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cis.2015.04.006","article-title":"Nanocarriers for the Delivery of Active Ingredients\nand Fractions\nExtracted from Natural Products Used in Traditional Chinese Medicine\n(TCM)","volume":"221","author":"Liu","year":"2015","journal-title":"Adv. Colloid Interface Sci."},{"key":"2026081810123401500_cit26","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.3109\/10717544.2015.1116025","article-title":"Advance of\nthe Application of Nano-Controlled\nRelease System in Ophthalmic Drug Delivery","volume":"23","author":"Wang","year":"2016","journal-title":"Drug Delivery"},{"key":"2026081810123401500_cit27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jhep.2014.03.009","article-title":"Traditional Chinese Medicine (TCM)\nfor Fibrotic Liver\nDisease: Hope and Hype","volume":"61","author":"Zhang","year":"2014","journal-title":"J. Hepatol."},{"key":"2026081810123401500_cit28","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1126\/science.1252553","article-title":"Interfacial Effects\nin Iron-Nickel Hydroxide\u2013Platinum Nanoparticles Enhance Catalytic\nOxidation","volume":"344","author":"Chen","year":"2014","journal-title":"Science"},{"key":"2026081810123401500_cit29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00204-015-1580-z","article-title":"A Comprehensive\nOverview of Hepatoprotective Natural\nCompounds: Mechanism of Action and Clinical Perspectives","volume":"90","author":"Domitrovic","year":"2016","journal-title":"Arch. Toxicol."},{"key":"2026081810123401500_cit30","doi-asserted-by":"publisher","first-page":"173976","DOI":"10.1016\/j.ejphar.2021.173976","article-title":"Research Progress\nin Use of Traditional Chinese Medicine Monomer for Treatment of Non-Alcoholic\nFatty Liver Disease","volume":"898","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"2026081810123401500_cit31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.apsb.2019.11.017","article-title":"Herbal Drug Discovery\nfor the Treatment of Nonalcoholic\nFatty Liver Disease","volume":"10","author":"Yan","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"2026081810123401500_cit32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8749564","article-title":"Nonalcoholic Fatty Liver Disease:\nPathogenesis and Treatment in Traditional Chinese Medicine and Western\nMedicine","volume":"2020","author":"Shi","year":"2020","journal-title":"Evidence-Based Complementary and Alternative\nMedicine"},{"key":"2026081810123401500_cit33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3389\/fphar.2016.00201","article-title":"Synergistic Effects of Chinese Herbal\nMedicine: A Comprehensive Review of Methodology and Current Research","volume":"7","author":"Zhou","year":"2016","journal-title":"Front. Pharmacol."},{"key":"2026081810123401500_cit34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/6178358","article-title":"Yinchen\nLinggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease\nin Rats by Regulating the Nrf2\/ARE Signaling Pathway","volume":"2017","author":"Guo","year":"2017","journal-title":"Evid.-based Complement Altern. Med."},{"key":"2026081810123401500_cit35","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3892\/ijmm_00000412","article-title":"Alleviation of Hepatic\nOxidative Stress by Chinese Herbal Medicine Yin-Chen-Hao-Tang in Obese\nMice with Steatosis","volume":"25","author":"Lee","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"2026081810123401500_cit36","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s11655-012-0993-2","article-title":"Chinese Herbal\nMedicine in the Treatment\nof Nonalcoholic Fatty Liver Disease","volume":"18","author":"Dong","year":"2012","journal-title":"Chin. J.\nIntegr. Med."},{"key":"2026081810123401500_cit37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.53388\/DCT201904004","article-title":"Research Progress\nof Yinchenhao Decoction in the Treatment of Non-Alcoholic Fatty Liver\nDisease","volume":"1","author":"Ma","year":"2019","journal-title":"Drug Comb. Ther."},{"key":"2026081810123401500_cit38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12906-018-2424-1","article-title":"The Traditional Chinese\nFormulae Ling-Gui-Zhu-Gan Decoction Alleviated Non-Alcoholic Fatty\nLiver Disease via Inhibiting PPP1R3C Mediated Molecules","volume":"19","author":"Dang","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081810123401500_cit39","doi-asserted-by":"publisher","first-page":"82621","DOI":"10.18632\/oncotarget.19734","article-title":"Lingguizhugan Decoction Improves\nNon-Alcoholic Fatty Liver Disease\nby Altering Insulin Resistance and Lipid Metabolism Related Genes:\nA Whole Trancriptome Study by RNA-Seq","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"2026081810123401500_cit40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2790864","article-title":"Lingguizhugan Decoction\nProtects against High-Fat-Diet-Induced Nonalcoholic\nFatty Liver Disease by Alleviating Oxidative Stress and Activating\nCholesterol Secretion","volume":"2017","author":"Yang","year":"2017","journal-title":"Int. J. Genomics"},{"key":"2026081810123401500_cit41","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12906-017-1557-y","article-title":"Modified Lingguizhugan\nDecoction\nIncorporated with Dietary Restriction and Exercise Ameliorates Hyperglycemia,\nHyperlipidemia and Hypertension in a Rat Model of the Metabolic Syndrome","volume":"17","author":"Yao","year":"2017","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081810123401500_cit42","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0254-6272(11)60038-1","article-title":"Effects of the Modified Linggui Zhugan\nDecoction (see text) Combined with Short-Term Very Low Calorie Diets\non Glycemic Control in Newly Diagnosed Type 2 Diabetics","volume":"31","author":"Chen","year":"2011","journal-title":"J. Tradit. Chin. Med."},{"key":"2026081810123401500_cit43","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.biopha.2018.03.158","article-title":"Effects of Shenling\nBaizhu Powder Herbal Formula on Intestinal Microbiota in High-Fat\nDiet-Induced NAFLD Rats","volume":"102","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit44","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.3390\/molecules24213943","article-title":"Lipidomic\nAnalysis of the Protective Effects of Shenling Baizhu San\non Non-Alcoholic Fatty Liver Disease in Rats","volume":"24","author":"Deng","year":"2019","journal-title":"Molecules"},{"key":"2026081810123401500_cit45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/9701285","article-title":"Prevention\nof Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement\nof Adiponectin-Induced Inhibition of Hepatic SREBP-1c","volume":"2020","author":"Tang","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026081810123401500_cit46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8479680","article-title":"Chinese Herbal Medicine Formula Shenling\nBaizhu San Ameliorates High-Fat Diet-Induced NAFLD in Rats by Modulating\nHepatic MicroRNA Expression Profiles","volume":"2019","author":"Pan","year":"2019","journal-title":"Evid.-based\nComplement Altern. Med."},{"key":"2026081810123401500_cit47","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4314\/ajtcam.v11i1.34","article-title":"p38 MAPK Signal Pathway Involved\nin Anti-Inflammatory Effect of Chaihu-Shugan-San and Shen-Ling-Bai-Zhu-San\non Hepatocyte in Non-Alcoholic Steatohepatitis Rats","volume":"11","author":"Yang","year":"2013","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"2026081810123401500_cit48","first-page":"1004","article-title":"Systematic Evaluation\nand Meta Analysis on Nonalcoholic Fatty Liver Disease Treated with\nChaihu Shugan San","volume":"9","author":"Zhang","year":"2014","journal-title":"World J. Integr. Tradit.\nWest. Med."},{"key":"2026081810123401500_cit49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/9390786","article-title":"Chaihu-Shugan-San\nDecoction Modulates Intestinal Microbe\nDysbiosis and Alleviates Chronic Metabolic Inflammation in NAFLD Rats via the NLRP3 Inflammasome Pathway","volume":"2018","author":"Liang","year":"2018","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"2026081810123401500_cit50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s11655-018-2829-6","article-title":"Effect\nof Soothing Gan (Liver) and\nInvigorating Pi (Spleen) Recipes on TLR4-P38 MAPK Pathway in Kupffer\nCells of Non-Alcoholic Steatohepatitis Rats","volume":"25","author":"Gong","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"2026081810123401500_cit51","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11655-016-2252-4","article-title":"Protective Effects\nof Chaihu Shugan San (see text) on Nonalcoholic Fatty Liver Disease\nin Rats with Insulin Resistance","volume":"24","author":"Jiang","year":"2018","journal-title":"Chin. J. Integr.\nMed."},{"key":"2026081810123401500_cit52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jep.2018.03.031","article-title":"Citri Reticulatae\nPericarpium (Chenpi): Botany, Ethnopharmacology,\nPhytochemistry, and Pharmacology of a Frequently Used Traditional\nChinese Medicine","volume":"220","author":"Yu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"2026081810123401500_cit53","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4103\/wjtcm.wjtcm_38_19","article-title":"Effects of Dachaihu\nDecoction and Its \u201cPrescription Elements\u201d on Intestinal\nFlora of Nonalcoholic Fatty Liver Disease Model Rats","volume":"6","author":"Sun","year":"2020","journal-title":"World J. Tradit. Chin. Med."},{"key":"2026081810123401500_cit54","first-page":"253","article-title":"Sini Powder Ameliorates\nthe Inflammatory Response in Rats with Stress-Induced Non-Alcoholic\nFatty Liver Disease by Inhibiting the Nuclear Factor Kappa-B\/Pyrin\nDomain-Containing Protein 3 Pathway","volume":"40","author":"Mu","year":"2020","journal-title":"J. Tradit.\nChin. Med."},{"key":"2026081810123401500_cit55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/1589871","article-title":"Erchen Decoction and Linguizhugan\nDecoction Ameliorate Hepatic Insulin Resistance by Inhibiting IRS-1Ser307\nPhosphorylation in Vivo and in Vitro","volume":"2017","author":"Zhang","year":"2017","journal-title":"Evidence-Based Complementary and Alternative\nMedicine"},{"key":"2026081810123401500_cit56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7465272","article-title":"Hepatoprotective\nEffect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease\nInduced by Methionine-Choline-Deficient Diet in Rat","volume":"2019","author":"Feng","year":"2019","journal-title":"BioMed Res. Int."},{"key":"2026081810123401500_cit57","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/medicines5030106","article-title":"Effects of Shugan-Jianpi\nRecipe on the Expression of the p38 MAPK\/NF-kappaB Signaling Pathway\nin the Hepatocytes of NAFLD Rats","volume":"5","author":"Deng","year":"2018","journal-title":"Medicines"},{"key":"2026081810123401500_cit58","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12906-019-2641-2","article-title":"Jiang-Zhi Granules\nDecrease Sensitivity to Low-Dose CCl4 Induced Liver Injury\nin NAFLD Rats through Reducing Endoplasmic Reticulum Stress","volume":"19","author":"Yang","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081810123401500_cit59","doi-asserted-by":"publisher","first-page":"153140","DOI":"10.1016\/j.phymed.2019.153140","article-title":"Protective Effect of\nHedansanqi Tiaozhi Tang against Non-Alcoholic Fatty Liver Disease in Vitro and in Vivo through Activating\nNrf2\/HO-1 Antioxidant Signaling Pathway","volume":"67","author":"Qiu","year":"2020","journal-title":"Phytomedicine"},{"key":"2026081810123401500_cit60","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jep.2019.03.006","article-title":"Protective Effect and Mechanism of\nQiwei Tiexie Capsule\non 3T3-L1 Adipocytes Cells and Rats with Nonalcoholic Fatty Liver\nDisease by Regulating LXRalpha, PPARgamma, and NF-kappaB-iNOS-NO Signaling\nPathways","volume":"236","author":"Suolang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"2026081810123401500_cit61","doi-asserted-by":"publisher","first-page":"7261619","DOI":"10.1155\/2018\/7261619","article-title":"Modulation\nof the Gut Microbiota in Rats by Hugan Qingzhi Tablets\nduring the Treatment of High-Fat-Diet-Induced Nonalcoholic Fatty Liver\nDisease","volume":"2018","author":"Tang","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026081810123401500_cit62","doi-asserted-by":"publisher","first-page":"109734","DOI":"10.1016\/j.biopha.2019.109734","article-title":"Huang-Qi San Improves Glucose and\nLipid Metabolism and Exerts Protective Effects against Hepatic Steatosis\nin High Fat Diet-Fed Rats","volume":"126","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit63","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s00018-019-03011-w","article-title":"The Links\nBetween the Gut Microbiome and Non-Alcoholic\nFatty Liver Disease (NAFLD)","volume":"76","author":"Safari","year":"2019","journal-title":"Cell. Mol. Life\nSci."},{"key":"2026081810123401500_cit64","first-page":"27","article-title":"Plants: A\nRich Source of Herbal Medicine","volume":"1","author":"Tiwari","year":"2008","journal-title":"J. Nat. Prod."},{"key":"2026081810123401500_cit65","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jgr.2015.07.006","article-title":"Anti-Inflammatory\nand Antifatigue Effect of Korean Red Ginseng in Patients with Nonalcoholic\nFatty Liver Disease","volume":"40","author":"Hong","year":"2016","journal-title":"J. Ginseng Res."},{"key":"2026081810123401500_cit66","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1142\/S0192415X18500817","article-title":"Beneficial\nEffects of Korean Red\nGinseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4Modulation","volume":"46","author":"Jeong","year":"2018","journal-title":"Am. J. Chin.\nMed."},{"key":"2026081810123401500_cit67","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12906-019-2465-0","article-title":"Green Cardamom Supplementation\nImproves Serum Irisin, Glucose Indices, and Lipid Profiles in Overweight\nor Obese Non-Alcoholic Fatty Liver Disease Patients: A Double-Blind\nRandomized Placebo-Controlled Clinical Trial","volume":"19","author":"Daneshi-Maskooni","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081810123401500_cit68","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2147\/CEG.S234698","article-title":"Effect of Ginger Powder Supplementation in Patients\nwith Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial","volume":"13","author":"Rafie","year":"2020","journal-title":"Clin. Exp. Gastroenterol."},{"key":"2026081810123401500_cit69","doi-asserted-by":"publisher","first-page":"102428","DOI":"10.1016\/j.ctim.2020.102428","article-title":"Effects of Garlic Powder\nSupplementation on Insulin Resistance, Oxidative Stress, and Body\nComposition in Patients with Non-Alcoholic Fatty Liver Disease: A\nRandomized Controlled Clinical Trial","volume":"51","author":"Sangouni","year":"2020","journal-title":"Complement.\nTher. Med."},{"key":"2026081810123401500_cit70","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1017\/S0007114520001403","article-title":"Effect of Garlic Powder\nSupplementation on Hepatic Steatosis, Liver Enzymes and Lipid Profile\nin Patients with Non-Alcoholic Fatty Liver Disease: A Double-Blind\nRandomised Controlled Clinical Trial","volume":"124","author":"Sangouni","year":"2020","journal-title":"Br. J.\nNutr."},{"key":"2026081810123401500_cit71","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1017\/S0007114520000318","article-title":"Flaxseed Oil in the\nContext of a Weight Loss Program Ameliorates Fatty Liver Grade in\nPatients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind\nControlled Trial","volume":"123","author":"Rezaei","year":"2020","journal-title":"Br. J. Nutr."},{"key":"2026081810123401500_cit72","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1024\/0300-9831\/a000568","article-title":"Turmeric and Chicory\nSeed Have Beneficial Effects on\nObesity Markers and Lipid Profile in Non-Alcoholic Fatty Liver Disease\n(NAFLD)","volume":"89","author":"Ghaffari","year":"2019","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"2026081810123401500_cit73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/4168380","article-title":"Green Tea\nPrevents NAFLD by Modulation\nof miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model","volume":"2019","author":"Torres","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026081810123401500_cit74","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1039\/C8FO01630E","article-title":"Spinach\nConsumption Ameliorates the Gut Microbiota and Dislipaemia in Rats\nwith Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD)","volume":"10","author":"Elvira-Torales","year":"2019","journal-title":"Food Funct."},{"key":"2026081810123401500_cit75","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/diseases6030080","article-title":"Potential\nTherapeutic Benefits of Herbs and Supplements in Patients with NAFLD","volume":"6","author":"Perumpail","year":"2018","journal-title":"Diseases"},{"key":"2026081810123401500_cit76","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/978-1-61779-624-1_13","article-title":"Extraction of Plant\nSecondary Metabolites","volume":"864","author":"Jones","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"2026081810123401500_cit77","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.3390\/molecules22071186","article-title":"Solvent Supercritical\nFluid Technologies to Extract Bioactive Compounds from Natural Sources:\nA Review","volume":"22","author":"Khaw","year":"2017","journal-title":"Molecules"},{"key":"2026081810123401500_cit78","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s11130-018-0687-9","article-title":"Enhancement of Bioactivity of Natural\nExtracts by Non-Thermal\nHigh Hydrostatic Pressure Extraction","volume":"73","author":"Scepankova","year":"2018","journal-title":"Plant\nFoods Hum. Nutr."},{"key":"2026081810123401500_cit79","doi-asserted-by":"publisher","first-page":"6351","DOI":"10.1039\/C9FO01199D","article-title":"Green Tea Extract Inhibits Early\nOncogenic Responses in Mice with Nonalcoholic Steatohepatitis","volume":"10","author":"Dey","year":"2019","journal-title":"Food Funct."},{"key":"2026081810123401500_cit80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141227","article-title":"Green Tea Extract\nRich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet","volume":"10","author":"Santamarina","year":"2015","journal-title":"PLoS One"},{"key":"2026081810123401500_cit81","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jnutbio.2017.10.016","article-title":"Green Tea\nExtract Protects against Hepatic NF\u03baB Activation along the Gut-Liver\nAxis in Diet-Induced Obese Mice with Nonalcoholic Steatohepatitis\nby Reducing Endotoxin and TLR4\/MyD88 Signaling","volume":"53","author":"Li","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"2026081810123401500_cit82","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.biopha.2018.11.069","article-title":"Wuzhi Capsule\n(Schisandra Sphenanthera Extract) Attenuates Liver Steatosis and Inflammation\nduring Non-Alcoholic Fatty Liver Disease Development","volume":"110","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit83","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/nu11020426","article-title":"Eucommia\nUlmoides Leaf Extract Ameliorates Steatosis Induced by High-Fat Diet\nin Rats by Increasing Lysosomal Function","volume":"11","author":"Lee","year":"2019","journal-title":"Nutrients"},{"key":"2026081810123401500_cit84","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.3390\/molecules23123213","article-title":"Modulation of Gut\nMicrobiota by Lonicera caerulea L.Berry Polyphenols in a Mouse Model\nof Fatty Liver Induced by High Fat Diet","volume":"23","author":"Wu","year":"2018","journal-title":"Molecules"},{"key":"2026081810123401500_cit85","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1002\/ptr.6073","article-title":"Efficacy of Artichoke\nLeaf Extract in Non-Alcoholic Fatty Liver Disease: A Pilot Double-Blind\nRandomized Controlled Trial","volume":"32","author":"Panahi","year":"2018","journal-title":"Phytother. Res."},{"key":"2026081810123401500_cit86","doi-asserted-by":"publisher","first-page":"100165","DOI":"10.1016\/j.obmed.2019.100165","article-title":"The Effects\nof Crocus Sativus Extract on Serum Lipid Profile and Liver Enzymes\nin Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Placebo-Controlled\nStudy","volume":"17","author":"Parsi","year":"2020","journal-title":"Obes. Med."},{"key":"2026081810123401500_cit87","doi-asserted-by":"publisher","first-page":"102290","DOI":"10.1016\/j.ctim.2019.102290","article-title":"Effect of Green Coffee Extract Supplementation on Serum\nAdiponectin Concentration and Lipid Profile in Patients with Non-Alcoholic\nFatty Liver Disease: A Randomized","volume":"49","author":"Hosseinabadi","year":"2020","journal-title":"Controlled\nTrial. Complement. Ther. Med."},{"key":"2026081810123401500_cit88","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.3390\/nu11112586","article-title":"Efficacy\nand Mechanism of Polymerized Anthocyanin from\nGrape-Skin Extract on High-Fat-Diet-Induced Nonalcoholic Fatty Liver\nDisease","volume":"11","author":"Fan","year":"2019","journal-title":"Nutrients"},{"key":"2026081810123401500_cit89","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1002\/ptr.5492","article-title":"Ex\nVivo and in Situ Evaluation of \u2019Dispelling-Wind\u2019\nChinese Medicine Herb\u2013Drugs on Intestinal Absorption of Chlorogenic\nAcid","volume":"29","author":"Zhai","year":"2015","journal-title":"Phytother. Res."},{"key":"2026081810123401500_cit90","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.fbp.2018.03.001","article-title":"New Perspective in Extraction of Plant Biologically Active Compounds\nby Green Solvents","volume":"109","author":"Cvjetko\nBubalo","year":"2018","journal-title":"Food Bioprod. Process."},{"key":"2026081810123401500_cit91","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","article-title":"Techniques\nfor Extraction and Isolation\nof Natural Products: A Comprehensive Review","volume":"13","author":"Zhang","year":"2018","journal-title":"Chin. Med."},{"key":"2026081810123401500_cit92","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.indcrop.2018.06.011","article-title":"Extraction,\nPurification, and Bioactivities\nAnalyses of Polysaccharides from Glycyrrhiza Uralensis","volume":"122","author":"Wang","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"2026081810123401500_cit93","first-page":"2783","article-title":"Role of Resveratrol in Prevention\nand Therapy of Cancer:\nPreclinical and Clinical Studies","volume":"24","author":"Aggarwal","year":"2004","journal-title":"Anticancer\nRes."},{"key":"2026081810123401500_cit94","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health Benefits\nof Resveratrol: Evidence\nfrom Clinical Studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med. Res. Rev."},{"key":"2026081810123401500_cit95","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.nut.2016.09.001","article-title":"Alternative\nTreatment Methods Attenuate the Development\nof NAFLD: A Review of Resveratrol Molecular Mechanisms and Clinical\nTrials","volume":"34","author":"Charytoniuk","year":"2017","journal-title":"Nutrition"},{"key":"2026081810123401500_cit96","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.2174\/1381612826666200417165801","article-title":"Hepatoprotective Effects\nof Resveratrol in Non-Alcoholic\nFatty Live Disease","volume":"27","author":"Tejada","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"2026081810123401500_cit97","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.dld.2014.11.015","article-title":"Resveratrol Improves\nInsulin Resistance, Glucose and Lipid Metabolism\nin Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled\nTrial","volume":"47","author":"Chen","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"2026081810123401500_cit98","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1111\/dom.13268","article-title":"Effects of Resveratrol\nSupplementation on Liver Fat\nContent in Overweight and Insulin-Resistant Subjects: A Randomized,\nDouble-Blind, Placebo-Controlled Clinical Trial","volume":"20","author":"Kantartzis","year":"2018","journal-title":"Diabetes, Obes. Metab."},{"key":"2026081810123401500_cit99","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3892\/etm.2019.7607","article-title":"Effect of\nResveratrol on Non-Alcoholic Fatty Liver Disease","volume":"18","author":"Theodotou","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"2026081810123401500_cit100","doi-asserted-by":"publisher","first-page":"307","DOI":"10.15171\/apb.2018.036","article-title":"Effects of Pharmacologic Dose of\nResveratrol Supplementation on Oxidative\/Antioxidative Status Biomarkers\nin Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind,\nPlacebo-Controlled Trial","volume":"8","author":"Asghari","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"2026081810123401500_cit101","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1024\/0300-9831\/a000528","article-title":"No Beneficial Effects of Resveratrol\nSupplementation\non Atherogenic Risk Factors in Patients with Nonalcoholic Fatty Liver\nDisease","volume":"90","author":"Farzin","year":"2020","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"2026081810123401500_cit102","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3109\/00365521.2015.1107620","article-title":"Placebo-Controlled, Randomised Clinical Trial: High-Dose\nResveratrol Treatment for Non-Alcoholic Fatty Liver Disease","volume":"51","author":"Heeb\u00f8ll","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"2026081810123401500_cit103","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.cgh.2014.02.024","article-title":"Resveratrol Does Not Benefit Patients\nwith Nonalcoholic Fatty Liver Disease","volume":"12","author":"Chachay","year":"2014","journal-title":"Clin.\nGastroenterol. Hepatol."},{"key":"2026081810123401500_cit104","doi-asserted-by":"publisher","first-page":"889","DOI":"10.2174\/0929867324666170404142450","article-title":"Hepatic AMP Kinase\nas a Potential\nTarget for Treating Nonalcoholic Fatty Liver Disease: Evidence from\nStudies of Natural Products","volume":"25","author":"Xu","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"2026081810123401500_cit105","doi-asserted-by":"publisher","first-page":"311","DOI":"10.15403\/jgld.2014.1121.233.yck","article-title":"A Potential\nTreatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators","volume":"23","author":"Colak","year":"2020","journal-title":"J. Gastrointest. Liver Dis."},{"key":"2026081810123401500_cit106","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.3390\/ijms19113473","article-title":"Involvement of 5\u2032-Activated\nProtein Kinase (AMPK)\nin the Effects of Resveratrol on Liver Steatosis","volume":"19","author":"Trepiana","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810123401500_cit107","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1159\/000495898","article-title":"Resveratrol Ameliorates\nLipid Droplet Accumulation in Liver through a SIRT1\/ATF6-Dependent\nMechanism","volume":"51","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"2026081810123401500_cit108","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11010-016-2807-x","article-title":"Resveratrol\nSupplement Inhibited\nthe NF-\u03baB Inflammation Pathway through Activating AMPK\u03b1-SIRT1\nPathway in Mice with Fatty Liver","volume":"422","author":"Tian","year":"2016","journal-title":"Mol. Cell.\nBiochem."},{"key":"2026081810123401500_cit109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183541","article-title":"Resveratrol and Caloric Restriction\nPrevent Hepatic Steatosis by Regulating SIRT1-Autophagy Pathway and\nAlleviating Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats","volume":"12","author":"Ding","year":"2017","journal-title":"PLoS One"},{"key":"2026081810123401500_cit110","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1139\/apnm-2019-0057","article-title":"Resveratrol\nProtects against Nonalcoholic Fatty Liver Disease by Improving Lipid\nMetabolism and Redox Homeostasis via the PPAR\u03b1\nPathway","volume":"45","author":"Huang","year":"2020","journal-title":"Appl. Physiol., Nutr., Metab."},{"key":"2026081810123401500_cit111","doi-asserted-by":"publisher","first-page":"105667","DOI":"10.1016\/j.biocel.2019.105667","article-title":"Resveratrol\nAlleviates Non-Alcoholic Fatty Liver Disease through Epigenetic Modification\nof the Nrf2 Signaling Pathway","volume":"119","author":"Hosseini","year":"2020","journal-title":"Int. J. Biochem.\nCell Biol."},{"key":"2026081810123401500_cit112","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.3390\/ijms20246282","article-title":"Resveratrol Treatment Enhances the Cellular Response\nto Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic\nHepG2 Cells","volume":"20","author":"Ardid-Ruiz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810123401500_cit113","doi-asserted-by":"publisher","first-page":"108363","DOI":"10.1016\/j.jnutbio.2020.108363","article-title":"Targeting the Gut Microbiota with\nResveratrol: A Demonstration of Novel Evidence for the Management\nof Hepatic Steatosis","volume":"81","author":"Wang","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"2026081810123401500_cit114","doi-asserted-by":"publisher","first-page":"102147","DOI":"10.1016\/j.nano.2019.102147","article-title":"Mycophenolate\nCo-Administration with Quercetin via Lipid-Polymer\nHybrid Nanoparticles for Enhanced Breast Cancer Management","volume":"24","author":"Patel","year":"2020","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit115","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/ptr.5693","article-title":"Berberis Vulgaris and Berberine:\nAn Update Review","volume":"30","author":"Imenshahidi","year":"2016","journal-title":"Phytother. Res."},{"key":"2026081810123401500_cit116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134172","article-title":"Efficacy of Berberine\nin Patients\nwith Non-Alcoholic Fatty Liver Disease","volume":"10","author":"Yan","year":"2015","journal-title":"PLoS\nOne"},{"key":"2026081810123401500_cit117","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-019-1706-y","article-title":"Berberine Promotes the Recruitment\nand Activation of Brown Adipose Tissue in Mice and Humans","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"2026081810123401500_cit118","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12967-016-0982-x","article-title":"Lipid Profiling of\nthe Therapeutic Effects of Berberine in Patients\nwith Nonalcoholic Fatty Liver Disease","volume":"14","author":"Chang","year":"2016","journal-title":"J. Transl.\nMed."},{"key":"2026081810123401500_cit119","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.4268\/cjcmm20112127","article-title":"Research on\nTherapeutic Effect and Hemorrheology Change of Berberine in New Diagnosed\nPatients with Type 2 Diabetes Combining Nonalcoholic Fatty Liver Disease","volume":"36","author":"Xie","year":"2011","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"2026081810123401500_cit120","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2019.06.019","article-title":"Berberine Attenuates Nonalcoholic\nHepatic Steatosis through the AMPK-SREBP-1c-SCD1 Pathway","volume":"141","author":"Zhu","year":"2019","journal-title":"Free Radical Biol. Med."},{"key":"2026081810123401500_cit121","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ejphar.2011.07.036","article-title":"Berberine Reducing\nInsulin Resistance\nby Up-Regulating IRS-2 Mrna Expression in Nonalcoholic Fatty Liver\nDisease (NAFLD) Rat Liver","volume":"668","author":"Xing","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"2026081810123401500_cit122","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.1096\/fj.201802316R","article-title":"Berberine\nAlleviates Nonalcoholic\nFatty Liver Induced by a High-Fat Diet in Mice by Activating SIRT3","volume":"33","author":"Xu","year":"2019","journal-title":"FASEB J."},{"key":"2026081810123401500_cit123","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11596-019-1997-3","article-title":"Berberine Ameliorates\nHigh-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3\/AMPK\/ACC Pathway","volume":"39","author":"Zhang","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"2026081810123401500_cit124","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.3892\/etm.2019.7208","article-title":"Berberine\nAttenuates Hepatic Oxidative Stress in Rats with Non-Alcoholic Fatty\nLiver Disease via the Nrf2\/ARE Signalling Pathway","volume":"17","author":"Deng","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"2026081810123401500_cit125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232630","article-title":"Berberine Inhibits Free Fatty Acid\nand LPS-Induced Inflammation via Modulating ER Stress\nResponse in Macrophages and Hepatocytes","volume":"15","author":"Wang","year":"2020","journal-title":"PLoS\nOne"},{"key":"2026081810123401500_cit126","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fphar.2020.00185","article-title":"Berberine Inhibits\nNod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation\nand Pyroptosis in Nonalcoholic Steatohepatitis via the ROS\/TXNIP Axis","volume":"11","author":"Mai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2026081810123401500_cit127","doi-asserted-by":"publisher","first-page":"677","DOI":"10.4103\/pm.pm_584_16","article-title":"Amelioration of Intestinal\nBarrier Dysfunction by Berberine\nin the Treatment of Nonalcoholic Fatty Liver Disease in Rats","volume":"13","author":"Li","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"2026081810123401500_cit128","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an Active Component of\nTurmeric (Curcuma Longa), and Its Effects on Health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2026081810123401500_cit129","doi-asserted-by":"publisher","first-page":"108938","DOI":"10.1016\/j.biopha.2019.108938","article-title":"Therapeutic Effects of Curcumin and\nUrsodexycholic Acid on Non-Alcoholic Fatty Liver Disease","volume":"115","author":"Gheibi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit130","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14032","article-title":"The Long-Term\nProtective Effects of Neonatal Administration of Curcumin against\nNonalcoholic Steatohepatitis in High-Fructose-Fed Adolescent Rats","volume":"7","author":"Ibrahim","year":"2019","journal-title":"Physiol. Rep."},{"key":"2026081810123401500_cit131","doi-asserted-by":"publisher","first-page":"102322","DOI":"10.1016\/j.ctim.2020.102322","article-title":"Effects of Curcuminoids on Inflammatory\nStatus in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized\nControlled Trial","volume":"49","author":"Saberi-Karimian","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"2026081810123401500_cit132","doi-asserted-by":"publisher","first-page":"102447","DOI":"10.1016\/j.ctim.2020.102447","article-title":"A Pilot Study of the Effect of Curcumin\non Epigenetic\nChanges and DNA Damage among Patients with Non-Alcoholic Fatty Liver\nDisease: A Randomized, Double-Blind, Placebo-Controlled, Clinical\nTrial","volume":"51","author":"Hariri","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"2026081810123401500_cit133","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41430-018-0382-9","article-title":"The Effects\nof Curcumin Supplementation on Liver Enzymes, Lipid Profile, Glucose\nHomeostasis, and Hepatic Steatosis and Fibrosis in Patients with Non-Alcoholic\nFatty Liver Disease","volume":"73","author":"Saadati","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"2026081810123401500_cit134","doi-asserted-by":"publisher","first-page":"15989","DOI":"10.1002\/jcb.28877","article-title":"Curcuminoids\nPlus Piperine Improve\nNonalcoholic Fatty Liver Disease: A Clinical Trial","volume":"120","author":"Panahi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"2026081810123401500_cit135","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of Phytosomal Curcumin on\nAnthropometric Parameters, Insulin Resistance, Cortisolemia and Non-Alcoholic\nFatty Liver Disease Indices: A Double-Blind, Placebo-Controlled Clinical\nTrial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"2026081810123401500_cit136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172900","article-title":"New Evidence for the\nTherapeutic Potential of Curcumin to Treat Nonalcoholic Fatty Liver\nDisease in Humans","volume":"12","author":"Inzaugarat","year":"2017","journal-title":"PLoS One"},{"key":"2026081810123401500_cit137","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1080\/10286020.2018.1505873","article-title":"Efficacy of Phospholipidated Curcumin\nin Nonalcoholic Fatty Liver Disease: A Clinical Study","volume":"21","author":"Panahi","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"2026081810123401500_cit138","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.biopha.2018.05.135","article-title":"Curcumin Regulates Endogenous and\nExogenous Metabolism via Nrf2-FXR-LXR Pathway in\nNAFLD Mice","volume":"105","author":"Yan","year":"2018","journal-title":"Biomed.\nPharmacother."},{"key":"2026081810123401500_cit139","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.3390\/nu11112702","article-title":"Curcumin Ameliorates Nonalcoholic Fatty Liver Disease\nthrough Inhibition of O-GlcNAcylation","volume":"11","author":"Lee","year":"2019","journal-title":"Nutrients"},{"key":"2026081810123401500_cit140","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/1751-2980.12610","article-title":"Fatty Liver\nMediated\nby Peroxisome Proliferator-Activated Receptor-A DNA Methylation Can\nBe Reversed by a Methylation Inhibitor and Curcumin","volume":"19","author":"Li","year":"2018","journal-title":"J. Dig. Dis."},{"key":"2026081810123401500_cit141","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12986-019-0410-3","article-title":"Curcumin Prevents High-Fat\nDiet-Induced Hepatic Steatosis in ApoE\u00ad(\u2212\/\u2212) Mice by\nImproving Intestinal Barrier Function and Reducing Endotoxin and Liver\nTLR4\/NF-\u03baB Inflammation","volume":"16","author":"Feng","year":"2019","journal-title":"Nutr. Metab."},{"key":"2026081810123401500_cit142","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/labinvest.2014.42","article-title":"Curcumin Eliminates\nthe Effect of\nAdvanced Glycation End-Products (Ages) on the Divergent Regulation\nof Gene Expression of Receptors of Ages by Interrupting Leptin Signaling","volume":"94","author":"Tang","year":"2014","journal-title":"Lab. Invest."},{"key":"2026081810123401500_cit143","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.4049\/jimmunol.1701495","article-title":"Curcumin Suppresses IL-1\u03b2 Secretion\nand Prevents Inflammation through Inhibition of the NLRP3 Inflammasome","volume":"200","author":"Yin","year":"2018","journal-title":"J. Immunol."},{"key":"2026081810123401500_cit144","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.intimp.2017.01.016","article-title":"Curcumin Ameliorates\nLiver Damage and Progression of NASH in NASH-HCC Mouse Model Possibly\nby Modulating HMGB1-NF-\u039aB Translocation","volume":"44","author":"Afrin","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"2026081810123401500_cit145","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3760\/cma.j.issn.1007-3418.2017.02.011","article-title":"Effect of Curcumin\non Intestinal Mucosal Mechanical Barrier in Rats with Non-Alcoholic\nFatty Liver Disease","volume":"25","author":"Hou","year":"2017","journal-title":"Zhonghua gan zang bing\nza zhi"},{"key":"2026081810123401500_cit146","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/ptr.6361","article-title":"Safety and\nToxicity of Silymarin, the Major Constituent of Milk Thistle Extract:\nAn Updated Review","volume":"33","author":"Soleimani","year":"2019","journal-title":"Phytother. Res."},{"key":"2026081810123401500_cit147","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s12325-020-01251-y","article-title":"Silymarin as Supportive\nTreatment\nin Liver Diseases: A Narrative Review","volume":"37","author":"Gillessen","year":"2020","journal-title":"Adv.\nTher."},{"key":"2026081810123401500_cit148","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/molecules22020191","article-title":"Silymarin\/Silybin\nand Chronic Liver Disease: A Marriage of Many Years","volume":"22","author":"Federico","year":"2017","journal-title":"Molecules"},{"key":"2026081810123401500_cit149","doi-asserted-by":"publisher","first-page":"e9061","DOI":"10.1097\/MD.0000000000009061","article-title":"The Therapeutic Effect of Silymarin\nin the Treatment of Nonalcoholic\nFatty Disease: A Meta-Analysis (PRISMA) of Randomized Control Trials","volume":"96","author":"Zhong","year":"2017","journal-title":"Medicine"},{"key":"2026081810123401500_cit150","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1016\/j.cgh.2017.04.016","article-title":"A Randomized Trial\nof Silymarin for the Treatment of Nonalcoholic Steatohepatitis","volume":"15","author":"Wah Kheong","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"2026081810123401500_cit151","doi-asserted-by":"publisher","first-page":"609","DOI":"10.21873\/invivo.11101","article-title":"A Long-Term Treatment with Silybin in Patients with\nNon-Alcoholic Steatohepatitis Stimulates Catalase Activity in Human\nEndothelial Cells","volume":"31","author":"Federico","year":"2017","journal-title":"IN VIVO"},{"key":"2026081810123401500_cit152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8742075","article-title":"Evaluation\nof the Effect Derived from Silybin with Vitamin D and Vitamin E Administration\non Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress\nParameters, and Serological Worsening Markers in Nonalcoholic Fatty\nLiver Disease Patients","volume":"2019","author":"Federico","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026081810123401500_cit153","first-page":"3118","article-title":"Effect of Silymarin Plus Vitamin\nE in Patients with Non-Alcoholic Fatty Liver Disease. A Randomized\nClinical Pilot Study","volume":"19","author":"Aller","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol.\nSci."},{"key":"2026081810123401500_cit154","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221683","article-title":"Silymarin in Non-Cirrhotics\nwith\nNon-Alcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo\nControlled Trial","volume":"14","author":"Navarro","year":"2019","journal-title":"PLoS One"},{"key":"2026081810123401500_cit155","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.3748\/wjg.v23.i27.5004","article-title":"Effect\nof Silymarin on Biochemical\nIndicators in Patients with Liver Disease: Systematic Review with\nMeta-Analysis","volume":"23","author":"de Avelar","year":"2017","journal-title":"World J. Gastroentero"},{"key":"2026081810123401500_cit156","doi-asserted-by":"publisher","first-page":"3398","DOI":"10.1007\/s10620-018-5268-0","article-title":"Silybin Alleviates\nHepatic Steatosis\nand Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement\nwith the Nf-\u03baB Pathway","volume":"63","author":"Ou","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"2026081810123401500_cit157","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/molecules24071280","article-title":"Silybin Modulates Collagen Turnover in an in Vitro Model of NASH","volume":"24","author":"Anfuso","year":"2019","journal-title":"Molecules"},{"key":"2026081810123401500_cit158","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.3390\/ijms19082165","article-title":"Silibinin\nAmeliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic\nSteatohepatitis","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810123401500_cit159","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13194","article-title":"Silymarin Attenuated Nonalcoholic\nFatty Liver Disease through the Regulation of Endoplasmic Reticulum\nStress Proteins GRP78 and XBP-1 in Mice","volume":"44","author":"Sahin","year":"2020","journal-title":"J.\nFood Biochem."},{"key":"2026081810123401500_cit160","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1096\/fj.201700602R","article-title":"Silybin Inhibits\nNLRP3 Inflammasome Assembly through the NAD\u00ad(+)\/SIRT2 Pathway in Mice\nwith Nonalcoholic Fatty Liver Disease","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB\nJ."},{"key":"2026081810123401500_cit161","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3390\/nu9101086","article-title":"Silibinin Restores\nNAD+ Levels and Induces the SIRT1\/AMPK Pathway in Non-Alcoholic\nFatty Liver","volume":"9","author":"Salomone","year":"2017","journal-title":"Nutrients"},{"key":"2026081810123401500_cit162","doi-asserted-by":"publisher","first-page":"632","DOI":"10.2174\/1871530319666190207163325","article-title":"Silibinin Ameliorates\nFructose-Induced Lipid Accumulation and Activates Autophagy in HepG2\nCells","volume":"19","author":"Li","year":"2019","journal-title":"Endocr., Metab. Immune Disord.: Drug\nTargets"},{"key":"2026081810123401500_cit163","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.biopha.2018.09.089","article-title":"Effect of Silibinin on CFLAR-JNK\nPathway in Oleic Acid-Treated HepG2 Cells","volume":"108","author":"Liu","year":"2018","journal-title":"Biomed.\nPharmacother."},{"key":"2026081810123401500_cit164","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/metabo10010029","article-title":"Biotransformation of Silymarin Flavonolignans\nby Human\nFecal Microbiota","volume":"10","author":"Valentova\u0301","year":"2020","journal-title":"Metabolites"},{"key":"2026081810123401500_cit165","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/hepr.13444","article-title":"Changes of Gut Microbiota\nduring Silybin-Mediated Treatment of High-Fat\nDiet-Induced Non-Alcoholic Fatty Liver Disease in Mice","volume":"50","author":"Li","year":"2020","journal-title":"Hepatol. Res."},{"key":"2026081810123401500_cit166","doi-asserted-by":"publisher","first-page":"107496","DOI":"10.1016\/j.pharmthera.2020.107496","article-title":"Berberine\nin the Treatment of Metabolism-Related Chronic Diseases: A Drug Cloud\n(dCloud) Effect to Target Multifactorial Disorders","volume":"209","author":"Kong","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"2026081810123401500_cit167","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5772\/54493","article-title":"Screening of Herbal\nMedicines for Potential Toxicities","volume-title":"New\nInsights into Toxicity and Drug Testing","author":"Ifeoma","year":"2013"},{"key":"2026081810123401500_cit168","first-page":"41","article-title":"Novel Insights\nof Toxicological Evaluation of Herbal Medicine: Human-Based Toxicological\nAssays","volume":"3","author":"Jayasinghe","year":"2017","journal-title":"Asian J. Pharm. Pharmacol."},{"key":"2026081810123401500_cit169","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jep.2015.01.004","article-title":"Investigation of the Active Components\nin Tripterygium Wilfordii\nLeading to Its Acute Hepatotoxicty and Nephrotoxicity","volume":"162","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"2026081810123401500_cit170","first-page":"2364","article-title":"Comparative\nResearch of Different Bupleurum Chinense Composition to Influence\nof Hepatotoxicity of Rats and Oxidative Damage Mechanism","volume":"34","author":"Lv","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"2026081810123401500_cit171","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1080\/14786419.2012.673604","article-title":"Potential Hepatotoxicity of Geniposide,\nthe Major Iridoid Glycoside in Dried Ripe Fruits of Gardenia Jasminoides\n(Zhi-Zi)","volume":"27","author":"Ding","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"2026081810123401500_cit172","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1158\/1055-9965.EPI-19-0023","article-title":"Herbal Medicine\nContaining Aristolochic\nAcid and the Risk of Primary Liver Cancer in Patients with Hepatitis\nC Virus Infection","volume":"28","author":"Chen","year":"2019","journal-title":"Cancer Epidemiol., Biomarkers\nPrev."},{"key":"2026081810123401500_cit173","doi-asserted-by":"publisher","first-page":"31898","DOI":"10.1038\/srep31898","article-title":"Distinct Response of the Hepatic Transcriptome to Aflatoxin\nB 1 Induced Hepatocellular Carcinogenesis and Resistance in Rats","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"key":"2026081810123401500_cit174","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/toxsci\/kfn255","article-title":"Toxicity Testing in\nthe 21st Century:\nBringing the Vision to Life","volume":"107","author":"Andersen","year":"2009","journal-title":"Toxicol. Sci."},{"key":"2026081810123401500_cit175","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jsps.2013.11.002","article-title":"Alternatives to\nAnimal Testing: A\nReview","volume":"23","author":"Doke","year":"2015","journal-title":"Saudi Pharm. J."},{"key":"2026081810123401500_cit176","doi-asserted-by":"publisher","first-page":"7272808","DOI":"10.1155\/2019\/7272808","article-title":"Toxicity\nAssessment of Herbal Medicine\nUsing Zebrafish Embryos: A Systematic Review","volume":"2019","author":"Jayasinghe","year":"2019","journal-title":"Evid.-based Complement Altern. Med."},{"key":"2026081810123401500_cit177","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13020-018-0218-5","article-title":"Application of Metabolomics\nin Toxicity Evaluation of Traditional Chinese Medicines","volume":"13","author":"Duan","year":"2018","journal-title":"Chin. Med."},{"key":"2026081810123401500_cit178","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000422","article-title":"In Silico and in Vivo Toxicological\nEvaluation of Paeonol","volume":"17","author":"Adki","year":"2020","journal-title":"Chem. Biodiversity"},{"key":"2026081810123401500_cit179","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.phrs.2017.12.020","article-title":"Medicinal\nPlants and Bioactive Natural Compounds in the Treatment of Non-Alcoholic\nFatty Liver Disease: A Clinical Review","volume":"130","author":"Bagherniya","year":"2018","journal-title":"Pharmacol.\nRes."},{"key":"2026081810123401500_cit180","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","article-title":"Bioavailability\nof Resveratrol","volume":"1215","author":"Walle","year":"2011","journal-title":"Ann. N. Y.\nAcad. Sci."},{"key":"2026081810123401500_cit181","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1124\/dmd.110.033936","article-title":"Extensive Intestinal\nFirst-Pass Elimination and Predominant Hepatic Distribution of Berberine\nExplain Its Low Plasma Levels in Rats","volume":"38","author":"Liu","year":"2010","journal-title":"Drug\nMetab. Dispos."},{"key":"2026081810123401500_cit182","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","article-title":"Oral Bioavailability of Curcumin: Problems and Advancements","volume":"24","author":"Liu","year":"2016","journal-title":"J. Drug Target."},{"key":"2026081810123401500_cit183","first-page":"321","article-title":"Chapter 3.30\n- Milk Thistle (Silybum marianum)","volume-title":"Nonvitamin and Nonmineral Nutritional Supplements","author":"Devi","year":"2019"},{"key":"2026081810123401500_cit184","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tifs.2016.07.004","article-title":"The Biological Activities,\nChemical\nStability, Metabolism and Delivery Systems of Quercetin: A Review","volume":"56","author":"Wang","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"2026081810123401500_cit185","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S1470-2045(18)30332-2","article-title":"Safety and Feasibility\nof Ultrasound-Triggered Targeted Drug Delivery of Doxorubicin from\nThermosensitive Liposomes in Liver Tumours (TARDOX): A Single-Centre,\nOpen-Label, Phase 1 Trial","volume":"19","author":"Lyon","year":"2018","journal-title":"Lancet Oncol."},{"key":"2026081810123401500_cit186","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.actbio.2015.11.031","article-title":"Docetaxel\n(DTX)-Loaded\nPolydopamine-Modified TPGS-PLA Nanoparticles as a Targeted Drug Delivery\nSystem for the Treatment of Liver Cancer","volume":"30","author":"Zhu","year":"2016","journal-title":"Acta\nBiomater."},{"key":"2026081810123401500_cit187","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jconrel.2017.11.029","article-title":"Pharmacokinetics\nof a Sustained Release Formulation of PDGF\u03b2-Receptor Directed\nCarrier Proteins to Target the Fibrotic Liver","volume":"269","author":"van Dijk","year":"2018","journal-title":"J. Controlled Release"},{"key":"2026081810123401500_cit188","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7150\/thno.37301","article-title":"Liver-Targeted Delivery of TSG-6 by Calcium Phosphate Nanoparticles\nfor the Management of Liver Fibrosis","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"2026081810123401500_cit189","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle\u2013Liver Interactions:\nCellular Uptake\nand Hepatobiliary Elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Controlled\nRelease"},{"key":"2026081810123401500_cit190","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.mattod.2018.10.040","article-title":"Nano-Carriers\nfor Delivery and Targeting of Active Ingredients of Chinese Medicine\nfor Hepatocellular Carcinoma Therapy","volume":"25","author":"Chen","year":"2019","journal-title":"Mater.\nToday"},{"key":"2026081810123401500_cit191","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.3109\/10717544.2014.945018","article-title":"Herbal and\nPolymeric Approaches for Liver-Targeting Drug Delivery: Novel Strategies\nand Their Significance","volume":"23","author":"Rohilla","year":"2016","journal-title":"Drug Delivery"},{"key":"2026081810123401500_cit192","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/aps.2018.33","article-title":"Importance of Integrating Nanotechnology\nwith Pharmacology and Physiology\nfor Innovative Drug Delivery and Therapy - An Illustration with Firsthand\nExamples","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"2026081810123401500_cit193","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3389\/fimmu.2020.00218","article-title":"Targeting\nof Hepatic Macrophages by Therapeutic Nanoparticles","volume":"11","author":"Colino","year":"2020","journal-title":"Front. Immunol."},{"key":"2026081810123401500_cit194","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine Delivery: A Matter of Size,\nGeometry, Kinetics and Molecular Patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat.\nRev. Immunol."},{"key":"2026081810123401500_cit195","doi-asserted-by":"publisher","first-page":"37577","DOI":"10.1074\/jbc.M101786200","article-title":"Determination of\nthe Upper Size Limit for Uptake and\nProcessing of Ligands by the Asialoglycoprotein Receptor on Hepatocytes in Vitro and in Vivo","volume":"276","author":"Rensen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2026081810123401500_cit196","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.2174\/092986712800784720","article-title":"Drug Targeting to Cancer by Nanoparticles\nSurface Functionalized with Special Biomolecules","volume":"19","author":"Holgado","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"2026081810123401500_cit197","doi-asserted-by":"publisher","first-page":"975","DOI":"10.2147\/IJN.S68861","article-title":"Liposomes as Nanomedical Devices","volume":"10","author":"Bozzuto","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"2026081810123401500_cit198","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ijpharm.2011.01.056","article-title":"Improving Solubility and Chemical\nStability of Natural\nCompounds for Medicinal Use by Incorporation into Liposomes","volume":"416","author":"Coimbra","year":"2011","journal-title":"Int. J. Pharm."},{"key":"2026081810123401500_cit199","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tifs.2019.01.013","article-title":"Liposomal Delivery of Natural Product:\nA Promising Approach in Health\nResearch","volume":"85","author":"Islam Shishir","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"2026081810123401500_cit200","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2217\/nnm-2018-0479","article-title":"A Cocktail of Betulinic\nAcid, Parthenolide, Honokiol and Ginsenoside Rh2 in Liposome Systems\nfor Lung Cancer Treatment","volume":"15","author":"Jin","year":"2020","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit201","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1039\/C8BM01530A","article-title":"Magnetic Liposomal\nEmodin Composite with Enhanced Killing Efficiency against Breast Cancer","volume":"7","author":"Song","year":"2019","journal-title":"Biomater. Sci."},{"key":"2026081810123401500_cit202","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ejmech.2019.01.007","article-title":"Composition Design\nand Medical Application of Liposomes","volume":"164","author":"Li","year":"2019","journal-title":"Eur. J.\nMed. Chem."},{"key":"2026081810123401500_cit203","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2017.09.002","article-title":"Immunomodulatory\nLiposomes Targeting Liver Macrophages\nArrest Progression of Nonalcoholic Steatohepatitis","volume":"78","author":"Maradana","year":"2018","journal-title":"Metab., Clin. Exp."},{"key":"2026081810123401500_cit204","doi-asserted-by":"publisher","first-page":"106208","DOI":"10.1016\/j.intimp.2020.106208","article-title":"Baicalin and\nIts Nanoliposomes Ameliorates Nonalcoholic\nFatty Liver Disease via Suppression of TLR4 Signaling\nCascade in Mice","volume":"80","author":"Liu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"2026081810123401500_cit205","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/molecules23092158","article-title":"Deoxyschizandrin Loaded\nLiposomes on the Suppression Lipid Accumulation\nin 3T3-L1 Adipocytes","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"key":"2026081810123401500_cit206","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.2217\/nnm-2017-0119","article-title":"Nanoliposome Improves\nInhibitory\nEffects of Naringenin on Nonalcoholic Fatty Liver Disease in Mice","volume":"12","author":"Chen","year":"2017","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit207","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1039\/C7FO01599B","article-title":"Sea Cucumber\nSaponin Liposomes Ameliorate Obesity-Induced Inflammation and Insulin\nResistance in High-Fat-Diet-Fed Mice","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"2026081810123401500_cit208","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.nano.2008.08.003","article-title":"Effect\nof Lipid Core Material on Characteristics of Solid Lipid Nanoparticles\nDesigned for Oral Lymphatic Delivery","volume":"5","author":"Paliwal","year":"2009","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit209","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3390\/nano9091204","article-title":"Improved Dermal Delivery\nof Cyclosporine\nA Loaded in Solid Lipid Nanoparticles","volume":"9","author":"Essaghraoui","year":"2019","journal-title":"Nanomaterials"},{"key":"2026081810123401500_cit210","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/13543776.2020.1720649","article-title":"Solid Lipid Nanoparticles: A Review\non Recent Perspectives\nand Patents","volume":"30","author":"Paliwal","year":"2020","journal-title":"Expert Opin. Ther. Pat."},{"key":"2026081810123401500_cit211","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ejps.2012.05.010","article-title":"Are Nanostructured\nLipid Carriers\n(NLCs) Better than Solid Lipid Nanoparticles (SLNs): Development,\nCharacterizations and Comparative Evaluations of Clotrimazole-Loaded\nSLNs and NLCs?","volume":"47","author":"Das","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"2026081810123401500_cit212","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ejpb.2016.10.015","article-title":"Topical Ophthalmic\nLipid Nanoparticle Formulations (SLN, NLC) of Indomethacin for Delivery\nto the Posterior Segment Ocular Tissues","volume":"109","author":"Balguri","year":"2016","journal-title":"Eur.\nJ. Pharm. Biopharm."},{"key":"2026081810123401500_cit213","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4103\/1735-5362.235156","article-title":"Solid Lipid Nanoparticles and Nanostructured\nLipid Carriers as Novel Drug Delivery Systems: Applications, Advantages\nand Disadvantages","volume":"13","author":"Ghasemiyeh","year":"2018","journal-title":"Res. Pharm. Sci."},{"key":"2026081810123401500_cit214","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1021\/acs.jafc.8b02246","article-title":"Study of the\nPhysicochemical Properties of Fish Oil Solid Lipid Nanoparticle in\nthe Presence of Palmitic Acid and Quercetin","volume":"67","author":"Azizi","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"2026081810123401500_cit215","doi-asserted-by":"publisher","first-page":"115682","DOI":"10.1016\/j.carbpol.2019.115682","article-title":"Targeted Delivery and\nApoptosis Induction\nof Trans-Resveratrol-Ferulic Acid Loaded Chitosan Coated Folic Acid\nConjugate Solid Lipid Nanoparticles in Colon Cancer Cells","volume":"231","author":"Senthil Kumar","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"2026081810123401500_cit216","doi-asserted-by":"publisher","first-page":"118506","DOI":"10.1016\/j.ijpharm.2019.118506","article-title":"Comparison\nof Different Aliphatic Acid Grafted N-Trimethyl\nChitosan Surface-Modified Nanostructured Lipid Carriers for Improved\nOral Kaempferol Delivery","volume":"568","author":"Du","year":"2019","journal-title":"Int. J. Pharm."},{"key":"2026081810123401500_cit217","doi-asserted-by":"publisher","first-page":"5049","DOI":"10.2147\/IJN.S84565","article-title":"Berberine-Loaded\nSolid Lipid Nanoparticles Are Concentrated\nin the Liver and Ameliorate Hepatosteatosis in db\/db Mice","volume":"10","author":"Xue","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"2026081810123401500_cit218","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2217\/nnm-2018-0001","article-title":"Self-Assembly\nand Directed Assembly of Lipid Nanocarriers\nfor Prevention of Liver Fibrosis in Obese Rats: A Comparison with\nthe Therapy of Bariatric Surgery","volume":"13","author":"Chen","year":"2018","journal-title":"Nanomedicine"},{"key":"2026081810123401500_cit219","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1177\/0885328213485141","article-title":"Binary Lipids-Based Nanostructured Lipid Carriers for Improved Oral\nBioavailability of Silymarin","volume":"28","author":"Shangguan","year":"2014","journal-title":"J. Biomater. Appl."},{"key":"2026081810123401500_cit220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214544","article-title":"Preparation and in Vitro Performance Evaluation\nof Resveratrol for Oral Self-Microemulsion","volume":"14","author":"Tang","year":"2019","journal-title":"PLoS One"},{"key":"2026081810123401500_cit221","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.2147\/IJN.S240449","article-title":"Self-Microemulsifying Drug Delivery\nSystem for Improved Oral Delivery and Hypnotic Efficacy of Ferulic\nAcid","volume":"15","author":"Liu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"2026081810123401500_cit222","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/colloids3040064","article-title":"Oil-in-Water\nMicroemulsions for Thymol Solubilization","volume":"3","author":"Ferna\u0301ndez-Pen\u0303a","year":"2019","journal-title":"Colloid\nInterfaces"},{"key":"2026081810123401500_cit223","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.apsb.2017.02.002","article-title":"Self-Microemulsifying\nDrug Delivery\nDystem for Improving the Bioavailability of Huperzine A by Lymphatic\nUptake","volume":"7","author":"Li","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"2026081810123401500_cit224","doi-asserted-by":"publisher","first-page":"7291","DOI":"10.2147\/IJN.S214883","article-title":"Oral Absorption and Lymphatic Transport\nof Baicalein Following Drug-Phospholipid\nComplex Incorporation in Self-Microemulsifying Drug Delivery Systems","volume":"14","author":"Liao","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"2026081810123401500_cit225","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1089\/jmf.2013.0033","article-title":"Protective\nEffect of Clove Oil and Eugenol Microemulsions on Fatty Liver and\nDyslipidemia as Components of Metabolic Syndrome","volume":"17","author":"Al-Okbi","year":"2014","journal-title":"J. Med. Food"},{"key":"2026081810123401500_cit226","doi-asserted-by":"publisher","first-page":"913","DOI":"10.5650\/jos.ess20067","article-title":"Basil Essential\nOil and Its Nanoemulsion Mitigate Non Alcoholic Steatohepatitis in\nRat Model with Special Reference to Gut Microbiota","volume":"69","author":"Al-Okbi","year":"2020","journal-title":"J. Oleo Sci."},{"key":"2026081810123401500_cit227","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.molliq.2016.10.138","article-title":"Enhanced Prevention of Progression\nof Non Alcoholic Fatty Liver to Steatohepatitis by Incorporating Pumpkin\nSeed Oil in Nanoemulsions","volume":"225","author":"Al-Okbi","year":"2017","journal-title":"J. Mol. Liq."},{"key":"2026081810123401500_cit228","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.3945\/jn.116.235374","article-title":"Compared\nwith Powdered Lutein, a Lutein Nanoemulsion Increases Plasma and Liver\nLutein, Protects against Hepatic Steatosis, and Affects Lipoprotein\nMetabolism in Guinea Pigs","volume":"146","author":"Murillo","year":"2016","journal-title":"J. Nutr."},{"key":"2026081810123401500_cit229","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","article-title":"Biodegradable\nPolymeric\nNanoparticles Based Drug Delivery Systems","volume":"75","author":"Kumari","year":"2010","journal-title":"Colloids\nSurf., B"},{"key":"2026081810123401500_cit230","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.2147\/DDDT.S165440","article-title":"Current Development of Biodegradable Polymeric Materials\nfor Biomedical Applications","volume":"12","author":"Song","year":"2018","journal-title":"Drug Des., Dev.\nTher."},{"key":"2026081810123401500_cit231","doi-asserted-by":"publisher","first-page":"104501","DOI":"10.1016\/j.reactfunctpolym.2020.104501","article-title":"Recent Advances\nin Natural Polymer-Based\nDrug Delivery Systems","volume":"148","author":"Tong","year":"2020","journal-title":"React. Funct. Polym."},{"key":"2026081810123401500_cit232","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s40005-019-00442-2","article-title":"Pegylated Polylactide (PLA) and Poly (Lactic-Co-Glycolic\nAcid) (PLGA) Copolymers for the Design of Drug Delivery Systems","volume":"49","author":"Perinelli","year":"2019","journal-title":"J. Pharm. Invest."},{"key":"2026081810123401500_cit233","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.msec.2019.04.069","article-title":"Thermo-Responsive\nPolymers: Applications of Smart Materials in Drug Delivery and Tissue\nEngineering","volume":"102","author":"Sponchioni","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"2026081810123401500_cit234","doi-asserted-by":"publisher","first-page":"181457","DOI":"10.1098\/rsos.181457","article-title":"Resveratrol-Loaded\nPLGA Nanoparticles: Enhanced Stability, Solubility and Bioactivity\nof Resveratrol for Non-Alcoholic Fatty Liver Disease Therapy","volume":"5","author":"Wan","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"2026081810123401500_cit235","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016914","article-title":"Efficacy\nof Nanocurcumin Supplementation on Insulin Resistance, Lipids, Inflammatory\nFactors and Nesfatin among Obese Patients with Non-Alcoholic Fatty\nLiver Disease (NAFLD): A Trial PAArotocol","volume":"7","author":"Jazayeri-Tehrani","year":"2017","journal-title":"BMJ.\nOpen"},{"key":"2026081810123401500_cit236","doi-asserted-by":"publisher","first-page":"67","DOI":"10.22038\/nmj.2018.005.003","article-title":"The Nanocurcumin\nReduces Appetite in Obese Patients with Non-Alcoholic Fatty Liver\nDisease (NAFLD): A Double-Blind Randomized Placebo-Controlled Clinical\nTrial","volume":"5","author":"Jazayeri-Tehrani","year":"2018","journal-title":"Nanomed. J."},{"key":"2026081810123401500_cit237","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12986-019-0331-1","article-title":"Nano-Curcumin\nImproves Glucose Indices, Lipids, Inflammation, and Nesfatin in Overweight\nand Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD):\nA Double-Blind Randomized Placebo-Controlled Clinical Trial","volume":"16","author":"Jazayeri-Tehrani","year":"2019","journal-title":"Nutr. Metab."},{"key":"2026081810123401500_cit238","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/app10010065","article-title":"Cellulose\nNanofibers and Other Biopolymers for Biomedical Applications","volume":"10","author":"Moohan","year":"2020","journal-title":"Appl. Sci."},{"key":"2026081810123401500_cit239","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.mtchem.2018.05.002","article-title":"Biopolymer\nBased Nanomaterials in Drug Delivery Systems: A Review","volume":"9","author":"Jacob","year":"2018","journal-title":"Mater. Today Chem."},{"key":"2026081810123401500_cit240","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1080\/10408398.2019.1630358","article-title":"Delivery of Synergistic Polyphenol Combinations Using\nBiopolymer-Based Systems: Advances in Physicochemical Properties,\nStability and Bioavailability","volume":"60","author":"Zhang","year":"2020","journal-title":"Crit. Rev. Food\nSci. Nutr."},{"key":"2026081810123401500_cit241","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.ijbiomac.2019.12.058","article-title":"Incorporation\nof Zataria Multiflora Essential Oil into Chitosan Biopolymer Nanoparticles:\nA Nanoemulsion Based Delivery System to Improve the in-Vitro Efficacy, Stability and Anticancer Activity of ZEO against Breast\nCancer Cells","volume":"143","author":"Salehi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081810123401500_cit242","first-page":"5","article-title":"Chitosan Nanoparticles\nas Hepato-Protective Agent against Alcohol and Fatty Diet Stress in\nRats","volume":"4","author":"Abdelhakim","year":"2017","journal-title":"J. Biochem. Int."},{"key":"2026081810123401500_cit243","doi-asserted-by":"publisher","first-page":"10683","DOI":"10.1021\/jf2020683","article-title":"Synthesis of Carboxymethylated and Quaternized Chitosans\nand Their Therapeutic Effect on Nonalcoholic Fatty Liver Disease","volume":"59","author":"Liu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"2026081810123401500_cit244","doi-asserted-by":"publisher","first-page":"1808197","DOI":"10.1002\/adfm.201808197","article-title":"Dual-Stimuli-Responsive Gut Microbiota-Targeting\nBerberine-CS\/PT-NPs Improved Metabolic Status in Obese Hamsters","volume":"29","author":"Guo","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"2026081810123401500_cit245","doi-asserted-by":"publisher","first-page":"1805730","DOI":"10.1002\/adma.201805730","article-title":"Degradability\nand Clearance of Inorganic Nanoparticles for Biomedical Applications","volume":"31","author":"Yang","year":"2019","journal-title":"Adv. Mater."},{"key":"2026081810123401500_cit246","doi-asserted-by":"publisher","first-page":"213092","DOI":"10.1016\/j.ccr.2019.213092","article-title":"Inorganic\nNanoparticles with Enzyme-Mimetic Activities for Biomedical Applications","volume":"403","author":"Kang","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"2026081810123401500_cit247","doi-asserted-by":"publisher","first-page":"196","DOI":"10.2174\/1573413716666200116124822","article-title":"Anti-Obesity Effect\nof Gold Nanoparticles from Dendropanax morbifera Le\u0301veille by Suppression of Triglyceride Synthesis and Downregulation of PPAR\u03b3\nand CEBP\u03b1 Signaling Pathways in 3T3-L1Mature Adipocytes and\nHepG2 Cells","volume":"16","author":"Yi","year":"2020","journal-title":"Curr. Nanosci."},{"key":"2026081810123401500_cit248","doi-asserted-by":"publisher","first-page":"12848","DOI":"10.1038\/s41598-019-49262-2","article-title":"Cerium Oxide Nanoparticles Display\nAntilipogenic Effect in Rats with Non-Alcoholic Fatty Liver Disease","volume":"9","author":"Carvajal","year":"2019","journal-title":"Sci. Rep."},{"key":"2026081810123401500_cit249","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.biopha.2017.03.099","article-title":"Cerium Dioxide Nanoparticles Possess Anti-Inflammatory\nProperties in the Conditions of the Obesity-Associated NAFLD in Rats","volume":"90","author":"Kobyliak","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"2026081810123401500_cit250","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.3390\/ijms20235959","article-title":"Cerium Oxide Nanoparticles Protect\nagainst Oxidant Injury and Interfere with Oxidative Mediated Kinase\nSignaling in Human-Derived Hepatocytes","volume":"20","author":"Carvajal","year":"2019","journal-title":"Int.\nJ. Mol. Sci."},{"key":"2026081810123401500_cit251","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1039\/C8CS00718G","article-title":"Nanozyme: New Horizons\nfor Responsive Biomedical Applications","volume":"48","author":"Jiang","year":"2019","journal-title":"Chem.\nSoc. Rev."},{"key":"2026081810123401500_cit252","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-981-15-1490-6_5","article-title":"Iron Oxide Nanozyme: A Multifunctional\nEnzyme Mimetics for Biomedical Application","volume-title":"Nanozymology: Connecting Biology and Nanotechnology","author":"Gao","year":"2020"},{"key":"2026081810123401500_cit253","doi-asserted-by":"publisher","first-page":"110528","DOI":"10.1016\/j.colsurfb.2019.110528","article-title":"Fe3O4@OA@Poloxamer Nanoparticles Lower Triglyceride in Hepatocytes\nthrough Liposuction Effect and Nano-Enzyme Effect","volume":"184","author":"Sun","year":"2019","journal-title":"Colloids Surf., B"},{"key":"2026081810123401500_cit254","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejps.2015.10.021","article-title":"Development\nand in Vitro Evaluation of Core\u2013Shell Type\nLipid\u2013Polymer Hybrid\nNanoparticles for the Delivery of Erlotinib in Non-Small Cell Lung\nCancer","volume":"81","author":"Mandal","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"2026081810123401500_cit255","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.procbio.2020.05.003","article-title":"Core-Shell\nAu@Co-Fe Hybrid Nanoparticles\nas Peroxidase Mimetic Nanozyme for Antibacterial Application","volume":"95","author":"Mirhosseini","year":"2020","journal-title":"Process Biochem."},{"key":"2026081810123401500_cit256","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12951-018-0391-9","article-title":"Chitosan-Functionalized Lipid-Polymer Hybrid Nanoparticles for Oral\nDelivery of Silymarin and Enhanced Lipid-Lowering Effect in NAFLD","volume":"16","author":"Liang","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"2026081810123401500_cit257","doi-asserted-by":"publisher","first-page":"66","DOI":"10.26655\/ajnanomat.2019.1.5","article-title":"Curcumin-Hybrid Nanoparticles\nin Drug Delivery System","volume":"2","author":"Deljoo","year":"2019","journal-title":"Asian J. Nanosci. Mater."},{"key":"2026081810123401500_cit258","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/cells8040359","article-title":"Therapeutic\nApplication of Micellar Solubilized Xanthohumol in a Western-Type\nDiet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty\nLiver Disease","volume":"8","author":"Mahli","year":"2019","journal-title":"Cells"},{"key":"2026081810123401500_cit259","doi-asserted-by":"publisher","first-page":"101874","DOI":"10.1016\/j.jddst.2020.101874","article-title":"The Isonicotinamide\nCocrystal Promotes Inhibitory Effects of Naringenin on Nonalcoholic\nFatty Liver Disease in Mice","volume":"59","author":"Jiang","year":"2020","journal-title":"J. Drug Delivery\nSci. Technol."},{"key":"2026081810123401500_cit260","doi-asserted-by":"publisher","first-page":"6420","DOI":"10.1021\/acs.jafc.0c01315","article-title":"Characterizations\nand Bioavailability of Dendrimer-Like Glucan Nanoparticulate System\nContaining Resveratrol","volume":"68","author":"Shi","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"2026081810123401500_cit261","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ymthe.2019.10.016","article-title":"HLSC-Derived\nExtracellular Vesicles Attenuate Liver Fibrosis and Inflammation in\na Murine Model of Non-Alcoholic Steatohepatitis","volume":"28","author":"Bruno","year":"2020","journal-title":"Mol. Ther."},{"key":"2026081810123401500_cit262","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/hep4.1290","article-title":"Combatting\nFibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis","volume":"3","author":"Chen","year":"2019","journal-title":"Hepatol. Commun."},{"key":"2026081810123401500_cit263","doi-asserted-by":"publisher","first-page":"3212643","DOI":"10.1155\/2018\/3212643","article-title":"Extracellular Vesicles from Amnion-Derived\nMesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis\nin Rats","volume":"2018","author":"Ohara","year":"2018","journal-title":"Stem Cells Int."},{"key":"2026081810123401500_cit264","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00681-w","article-title":"Blueberry-Derived Exosomes-Like Nanoparticles\nAmeliorate Nonalcoholic Fatty Liver Disease by Attenuating Mitochondrial\nOxidative Stress","author":"Zhao","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"2026081810123401500_cit265","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-3-030-29168-6_12","article-title":"Asialoglycoprotein\nReceptor and Targeting Strategies","volume-title":"Targeted\nIntracellular Drug Delivery by Receptor Mediated Endocytosis","author":"Das","year":"2019"},{"key":"2026081810123401500_cit266","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1021\/ja2104679","article-title":"Glycomimetic\nLigands for the Human Asialoglycoprotein Receptor","volume":"134","author":"Mamidyala","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026081810123401500_cit267","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jconrel.2019.06.023","article-title":"The Hepatic-Targeted,\nResveratrol Loaded Nanoparticles for Relief of High Fat Diet-Induced\nNonalcoholic Fatty Liver Disease","volume":"307","author":"Teng","year":"2019","journal-title":"J. Controlled\nRelease"},{"key":"2026081810123401500_cit268","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1038\/s41467-020-16991-2","article-title":"Silencing Hepatic MCJ\nAttenuates Non-Alcoholic Fatty Liver Disease (NAFLD) by Increasing\nMitochondrial Fatty Acid Oxidation","volume":"11","author":"Barbier-Torres","year":"2020","journal-title":"Nat. Commun."},{"key":"2026081810123401500_cit269","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1002\/hep4.1405","article-title":"A Therapeutic Silencing\nRNA Targeting Hepatocyte TAZ Prevents and\nReverses Fibrosis in Nonalcoholic Steatohepatitis in Mice","volume":"3","author":"Wang","year":"2019","journal-title":"Hepatol. Commun."},{"key":"2026081810123401500_cit270","doi-asserted-by":"publisher","first-page":"2002997","DOI":"10.1002\/advs.202002997","article-title":"Triantennary GalNAc Molecular Imaging\nProbes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic\nSteatohepatitis","volume":"7","author":"Mishra","year":"2020","journal-title":"Adv. Sci."},{"key":"2026081810123401500_cit271","doi-asserted-by":"publisher","first-page":"984578","DOI":"10.1155\/2015\/984578","article-title":"How Inflammation Impinges on NAFLD:\nA Role for Kupffer Cells","volume":"2015","author":"Duarte","year":"2015","journal-title":"BioMed Res. Int."},{"key":"2026081810123401500_cit272","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.molcel.2019.07.028","article-title":"Landscape of Intercellular Crosstalk\nin Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis","volume":"75","author":"Xiong","year":"2019","journal-title":"Mol. Cell"},{"key":"2026081810123401500_cit273","doi-asserted-by":"publisher","first-page":"114941","DOI":"10.1016\/j.taap.2020.114941","article-title":"Benzyl Isothiocyanate\nAmeliorates High-Fat\/Cholesterol\/Cholic Acid Diet-Induced Nonalcoholic\nSteatohepatitis through Inhibiting Cholesterol Crystal-Activated NLRP3\nInflammasome in Kupffer Cells","volume":"393","author":"Chen","year":"2020","journal-title":"Toxicol. Appl.\nPharmacol."},{"key":"2026081810123401500_cit274","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/hep.26604","article-title":"Free Cholesterol\nAccumulation in Hepatic Stellate Cells: Mechanism of Liver Fibrosis\nAggravation in Nonalcoholic Steatohepatitis in Mice","volume":"59","author":"Tomita","year":"2014","journal-title":"Hepatology"},{"key":"2026081810123401500_cit275","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/ijerph14010011","article-title":"Ameliorative Effect of Curcumin-Encapsulated\nHyaluronic Acid-PLA Nanoparticles on Thioacetamide-Induced Murine\nHepatic Fibrosis","volume":"14","author":"Chen","year":"2017","journal-title":"Int. J. Environ. Res. Public\nHealth"},{"key":"2026081810123401500_cit276","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tips.2019.05.002","article-title":"Genetic Insights for\nDrug Development\nin NAFLD","volume":"40","author":"Eslam","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"2026081810123401500_cit277","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.cgh.2019.01.027","article-title":"Prevalence\nand Risk Factors of Significant Fibrosis in Patients with Nonalcoholic\nFatty Liver without Steatohepatitis","volume":"17","author":"Pelusi","year":"2019","journal-title":"Clin. Gastroenterol.\nHepatol."},{"key":"2026081810123401500_cit278","first-page":"220","article-title":"Natural Products Drug Discovery:\nAccelerating the Clinical Candidate Development Using Reverse Pharmacology\nApproaches","volume":"48","author":"Patwardhan","year":"2010","journal-title":"Indian J. Exp. Biol."},{"key":"2026081810123401500_cit279","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.tips.2014.02.001","article-title":"Insights into\nDrug Discovery from\nNatural Medicines Using Reverse Pharmacokinetics","volume":"35","author":"Hao","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"2026081810123401500_cit280","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fphar.2019.00123","article-title":"Network Pharmacology\nDatabases for Traditional Chinese Medicine: Review and Assessment","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"2026081810123401500_cit281","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3390\/biom9080362","article-title":"The Methodological\nTrends of Traditional Herbal Medicine Employing Network Pharmacology","volume":"9","author":"Lee","year":"2019","journal-title":"Biomolecules"},{"key":"2026081810123401500_cit282","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1111\/jcmm.15166","article-title":"A Network Pharmacology-Based\nApproach\nto Explore the Effects of Chaihu Shugan Powder on a Non-Alcoholic\nFatty Liver Rat Model through Nuclear Receptors","volume":"24","author":"Nie","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"2026081810123401500_cit283","doi-asserted-by":"publisher","first-page":"CD011640","DOI":"10.1002\/14651858.CD011640.pub2","article-title":"Pharmacological Interventions for\nNon-Alcohol Related Fatty Liver Disease (NAFLD): An Attempted Network\nMeta-Analysis","volume":"3","author":"Lombardi","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"2026081810123401500_cit284","doi-asserted-by":"publisher","first-page":"j3932","DOI":"10.1136\/bmj.j3932","article-title":"Multivariate\nand\nNetwork Meta-Analysis of Multiple Outcomes and Multiple Treatments:\nRationale, Concepts, and Examples","volume":"358","author":"Riley","year":"2017","journal-title":"BMJ."},{"key":"2026081810123401500_cit285","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1530\/JME-18-0055","article-title":"Integrated\nOmics: Tools, Advances, and Future Approaches","volume":"62","author":"Misra","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"2026081810123401500_cit286","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tips.2015.11.010","article-title":"Intestinal Microbiota and Metabolic\nDiseases: Pharmacological Implications","volume":"37","author":"Shen","year":"2016","journal-title":"Trends\nPharmacol. Sci."},{"key":"2026081810123401500_cit287","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.biochi.2016.07.008","article-title":"Nano-Formulations\nof Drugs: Recent Developments","volume":"128\u2013129","author":"Jeevanandam","year":"2016","journal-title":"Biochimie"},{"key":"2026081810123401500_cit288","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.3390\/cells8101279","article-title":"Magnetic-Assisted Treatment\nof Liver\nFibrosis","volume":"8","author":"Levada","year":"2019","journal-title":"Cells"},{"key":"2026081810123401500_cit289","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.colsurfa.2019.03.063","article-title":"Polypyrrole-Coated Hollow Gold Nanoshell Exerts Anti-Obesity\nEffects via Photothermal Lipolysis","volume":"570","author":"Han","year":"2019","journal-title":"Colloids Surf., A"},{"key":"2026081810123401500_cit290","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/2666150002006010001","article-title":"Nanomedical\nDevices\nand Cancer Theranostics","volume":"6","author":"Moumaris","year":"2020","journal-title":"Open Nanomed. Nanotechnol.\nJ."},{"key":"2026081810123401500_cit291","doi-asserted-by":"publisher","first-page":"4782","DOI":"10.1002\/smll.201601129","article-title":"Recent Advances\nof Using Hybrid Nanocarriers in Remotely Controlled Therapeutic Delivery","volume":"12","author":"Li","year":"2016","journal-title":"Small"},{"key":"2026081810123401500_cit292","doi-asserted-by":"publisher","first-page":"7055","DOI":"10.3390\/ijms22137055","article-title":"Nanocarriers for Biomedicine: From Lipid Formulations\nto Inorganic and Hybrid Nanoparticles","volume":"22","author":"Kashapov","year":"2021","journal-title":"Int.\nJ. Mol. Sci."},{"key":"2026081810123401500_cit293","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/obr.12765","article-title":"Adipose May\nActively Delay Progression of NAFLD by Releasing Tumor-Suppressing,\nAnti-Fibrotic miR-122 into Circulation","volume":"20","author":"Baranova","year":"2019","journal-title":"Obes.\nRev."},{"key":"2026081810123401500_cit294","doi-asserted-by":"publisher","first-page":"e346","DOI":"10.1038\/emm.2017.63","article-title":"Mesenchymal Stem Cell-Derived\nExosomes as a New Therapeutic Strategy for Liver Diseases","volume":"49","author":"Lou","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"2026081810123401500_cit295","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bios.2019.04.045","article-title":"Porous Graphene-Black Phosphorus\nNanocomposite Modified Electrode for Detection of Leptin","volume":"137","author":"Cai","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"2026081810123401500_cit296","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1021\/acs.jmedchem.9b01701","article-title":"The Race to Bash NASH: Emerging Targets and Drug Development\nin a Complex Liver Disease","volume":"63","author":"Romero","year":"2020","journal-title":"J. Med. Chem."},{"issue":"Suppl\n1","key":"2026081810123401500_cit297","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/liv.14869","article-title":"Current Management of NAFLD\/NASH","volume":"41","author":"Cardoso","year":"2021","journal-title":"Liver Int."},{"key":"2026081810123401500_cit298","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1007\/s12325-021-01690-1","article-title":"Perspectives on Precision\nMedicine Approaches to NAFLD Diagnosis and Management","volume":"38","author":"Lonardo","year":"2021","journal-title":"Adv. Ther."},{"key":"2026081810123401500_cit299","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1109\/TMI.2021.3081097","article-title":"Non-Invasive\nPhotothermal Strain Imaging of Non-Alcoholic Fatty Liver Disease in\nLive Animals","volume":"40","author":"Choi","year":"2021","journal-title":"IEEE Trans. Med. Imaging"},{"key":"2026081810123401500_cit300","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/hep.31420","article-title":"From NAFLD\nto MAFLD: Implications of a Premature Change in Terminology","volume":"73","author":"Younossi","year":"2021","journal-title":"Hepatology"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.1c02158","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/15\/11\/17016\/15152084\/nn1c02158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/15\/11\/17016\/15152084\/nn1c02158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:57Z","timestamp":1787067777000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/15\/11\/17016\/1437687\/Design-of-Hepatic-Targeted-Drug-Delivery-Systems"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":300,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,10,27]]},"published-print":{"date-parts":[[2021,11,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.1c02158","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,27]]}}}